Abstract 297: Identifying Optimization Targets in 911 Dispatch Workflows for Out-of-hospital Cardiac Arrest Management

Autor: Cindy Polydoras, Nathaniel R Hunt, Kevin Irwin, Stephen Dowker, Robert Swor, Randy Bloom, Graham C Smith, Neil Kamdar, Michelle Williams, Brad Trumpower, Woodrow Sams, Michael F. N. O'Leary, Robert M. Domeier, Charles P. Friedman, Mahshid Abir, Emilee Coulter-thompson, Brahmajee K. Nallamothu, Robert W. Neumar

Publikováno v: Circulation. 142

Introduction: Dispatch processes for prehospital management of out-of-hospital cardiac arrest (OHCA) vary greatly by region, and so do the barriers and facilitators of rapid time-to-first-treatment within those systems. In order to optimize local OHC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5f6f91f9a7730925d5b74ec13c5e141
https://doi.org/10.1161/circ.142.suppl_4.297

Altered mitochondrial morphology and defective protein import reveal novel roles for Bax and/or Bak in skeletal muscle

Autor: Ayesha Saleem, Yuan Zhang, Michael F. N. O'Leary, David A. Hood, Sobia Iqbal, Keir J. Menzies, Shuzhe Ding

Publikováno v: American Journal of Physiology-Cell Physiology. 305:C502-C511

The function Bax and/or Bak in constituting a gateway for mitochondrial apoptosis in response to apoptotic stimuli has been unequivocally demonstrated. However, recent work has suggested that Bax/Bak may have unrecognized nonapoptotic functions relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5156d198f49032087302bbcc7e1dbf
https://doi.org/10.1152/ajpcell.00058.2013

Denervation-induced mitochondrial dysfunction and autophagy in skeletal muscle of apoptosis-deficient animals

Autor: David A. Hood, Yuan Zhang, Michael F. N. O′Leary, Heather N. Carter, Anna Vainshtein

Publikováno v: American Journal of Physiology-Cell Physiology. 303:C447-C454

Skeletal muscle undergoes remarkable adaptations in response to chronic decreases in contractile activity, such as a loss of muscle mass, decreases in both mitochondrial content and function, as well as the activation of apoptosis. Although these ada

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa89347a9efe9922afbaf4e51809d9e1
https://doi.org/10.1152/ajpcell.00451.2011

Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle

Autor: Béatrice Chabi, Peter J. Adhihetty, David A. Hood, Michael F. N. O'Leary, Karen L. Wicks

Publikováno v: Journal of Applied Physiology
Journal of Applied Physiology, American Physiological Society, 2007, 102 (3), pp.1143-1151. ⟨10.1152/japplphysiol.00768.2006⟩

Chronic muscle disuse induced by denervation reduces mitochondrial content and produces muscle atrophy. To investigate the molecular mechanisms responsible for these adaptations, we assessed 1) mitochondrial biogenesis- and apoptosis-related proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240f7633dbffa41a77c591e4f8a26d8c
https://doi.org/10.1152/japplphysiol.00768.2006

The effects of chronic muscle use and disuse on cardiolipin metabolism

Autor: Olga Ostojic, Keir J. Menzies, Kaustabh Singh, David A. Hood, Anna Vainshtein, Michael F. N. O'Leary

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 114(4)

Cardiolipin (CL) is a phospholipid that maintains the integrity of mitochondrial membranes. We previously demonstrated that CL content increases with chronic muscle use, and decreases with denervation-induced disuse. To investigate the underlying mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dd084f47569c3560c699210271198b
https://pubmed.ncbi.nlm.nih.gov/23221956