Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Michael F. Miles"'
Autor:
Jyoti Lodha, Emily R. Brocato, McKenzie Nash, Madison M. Marcus, A. Chris Pais, Alex B. Pais, Michael F. Miles, Jennifer Theresa Wolstenholme
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionAdolescence is a critical period in cognitive and emotional development, characterized by high levels of social interaction and increases in risk-taking behavior including binge drinking. Adolescent exposure to social stress and binge eth
Externí odkaz:
https://doaj.org/article/7549bd6df65143c79480223c1f931d2a
Autor:
Amanda Elswick Gentry, Jeffry C. Alexander, Mohammad Ahangari, Roseann E. Peterson, Michael F. Miles, Jill C. Bettinger, Andrew G. Davies, Mike Groteweil, Silviu A. Bacanu, Kenneth S. Kendler, Brien P. Riley, Bradley T. Webb
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Background Variation in genes involved in ethanol metabolism has been shown to influence risk for alcohol dependence (AD) including protective loss of function alleles in ethanol metabolizing genes. We therefore hypothesized that people with severe A
Externí odkaz:
https://doaj.org/article/e85b9ac00f1e47f39e8bbedcb5a659f3
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Despite the increasing use of RNAseq for transcriptome analysis, microarrays remain a widely-used methodology for genomic studies. The latest generation of Affymetrix/Thermo-Fisher microarrays, the ClariomD/XTA and ClariomS array,
Externí odkaz:
https://doaj.org/article/b25664a052ee4accbdb0c94ac21d1812
Autor:
James W. Bogenpohl, Maren L. Smith, Sean P. Farris, Catherine I. Dumur, Marcelo F. Lopez, Howard C. Becker, Kathleen A. Grant, Michael F. Miles
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Despite recent extensive genomic and genetic studies on behavioral responses to ethanol, relatively few new therapeutic targets for the treatment of alcohol use disorder have been validated. Here, we describe a cross-species genomic approach focused
Externí odkaz:
https://doaj.org/article/9b03caebd2ec4bafb5a4cfbfe0b19989
Autor:
Megan A. O’Brien, Rory M. Weston, Nihar U. Sheth, Steven Bradley, John Bigbee, Ashutosh Pandey, Robert W. Williams, Jennifer T. Wolstenholme, Michael F. Miles
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Alcoholism is a complex behavioral disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug
Externí odkaz:
https://doaj.org/article/9b0ee6e80a1e4e28b6d511a72bf85f56
Autor:
Alexander B. Pais, Anthony C. Pais, Gabriel Elmisurati, So Hyun Park, Michael F. Miles, Jennifer T. Wolstenholme
Publikováno v:
Brain Sciences, Vol 9, Iss 12, p 336 (2019)
Adolescence is characterized by high levels of playful social interaction, cognitive development, and increased risk-taking behavior. Juvenile exposure to social isolation or social stress can reduce myelin content in the frontal cortex, alter neuron
Externí odkaz:
https://doaj.org/article/ac838c11ca774f39a9b62baa03df4f9a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Adolescents primarily consume alcohol in binges, which can be particularly harmful to the developing frontal cortex and increase risk for an adult alcohol use disorder. We conducted a study investigating immediate and long lasting changes to the pref
Externí odkaz:
https://doaj.org/article/462e53b1276946c096e337def2e1c225
Autor:
Melanie A. Jones, Sami Amr, Aerial Ferebee, Phung Huynh, Jill A. Rosenfeld, Michael F. Miles, Andrew G. Davies, Christopher A. Korey, John M. Warrick, Rita Shiang, Sarah H. Elsea, Santhosh Girirajan, Mike Grotewiel
Publikováno v:
Biology Open, Vol 3, Iss 5, Pp 342-352 (2014)
Wolfram syndrome (WFS) is a progressive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. WFS1 and WFS2 are caused by recessive mutations in the genes Wolfram Syndrome 1 (WFS1) and CDGSH ir
Externí odkaz:
https://doaj.org/article/a4737ab2ef95465db24c433f7bac1e30
Autor:
Sean P. Farris, Michael F. Miles
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 115-121 (2012)
Alcoholism is a complex disease caused by a confluence of environmental and genetic factors influencing multiple brain pathways to produce a variety of behavioral sequelae, including addiction. Genetic factors contribute to over 50% of the risk for a
Externí odkaz:
https://doaj.org/article/8a4aeb2a8fa94935bb3a2a20efdfe520
Autor:
Megan Kathleen Mulligan, Candice eDuBose, Junming eYue, Michael F. Miles, Lu eLu, Kristin M Hamre
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
The role of miRNA and miRNA biogenesis genes in the adult brain is just beginning to be explored. In this study we have performed a comprehensive analysis of the expression, genetic regulation, and co-expression of major components of the miRNA bioge
Externí odkaz:
https://doaj.org/article/4d402e3c58ca40a6bcbaa68f0491d4f6