Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael F. Hoffmann"'
Autor:
Sarah C Preissner, Michael F Hoffmann, Robert Preissner, Mathias Dunkel, Andreas Gewiess, Saskia Preissner
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82562 (2013)
The cytochrome P450 (CYP) enzymes are major players in drug metabolism. More than 2,000 mutations have been described, and certain single nucleotide polymorphisms (SNPs) have been shown to have a large impact on CYP activity. Therefore, CYPs play an
Externí odkaz:
https://doaj.org/article/68e9130743584d218b9a356677ab61c2
Autor:
Saskia Preissner, Mathias Dunkel, Michael F Hoffmann, Sarah C Preissner, Nikolai Genov, Wen Wei Rong, Robert Preissner, Karlheinz Seeger
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51020 (2012)
BACKGROUND: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP). Furthermore, a
Externí odkaz:
https://doaj.org/article/20ea04f4d348434683ded95d4fd6dab6
Autor:
Mathias Dunkel, Robert Preissner, Janette Nickel, Saskia Preissner, Sarah C. Preissner, Michael F. Hoffmann
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research 42 (1): D1113-D1117.
Nucleic Acids Research 42 (1): D1113-D1117.
As the number of prescribed drugs is constantly rising, drug-drug interactions are an important issue. The simultaneous administration of several drugs can cause severe adverse effects based on interactions with the same metabolizing enzyme(s). The T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ba9467705b30a85e39354abbe1fb10
https://doi.org/10.1093/nar/gkt1246
https://doi.org/10.1093/nar/gkt1246
Autor:
Björn Oliver Gohlke, Michael D. R. Croning, August B. Smit, Joachim von Eichborn, Mathias Dunkel, Nicolas Le Novère, Martin Schaefer, Seth G. N. Grant, Pim van Nierop, J. D. Armstrong, Sarah C. Preissner, Robert Preissner, Miguel A. Andrade-Navarro, Jakob M. J. Bauer, Michael F. Hoffmann
Publikováno v:
Nucleic Acids Research; Vol 41
Nucleic Acids Research, 41(D1), D834-D840. Oxford University Press
von Eichborn, J, Dunkel, M, Gohlke, B O, Preissner, S C, Hoffmann, M F, Bauer, J M J, Armstrong, J D, Schaefer, M H, Andrade-Navarro, M A, Le Novere, N, Croning, M D R, Grant, S G N, van Nierop, P, Smit, A B & Preissner, R 2013, ' SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations ', Nucleic Acids Research, vol. 41, no. D1, pp. D834-D840 . https://doi.org/10.1093/nar/gks1040
Nucleic Acids Research
von Eichborn, J, Dunkel, M, Gohlke, B O, Preissner, S C, Hoffmann, M F, Bauer, J M J, Armstrong, D, Schaefer, M H, Andrade-Navarro, M A, Le Novere, N, Croning, M D R, Grant, S G N, van Nierop, P, Smit, A B & Preissner, R 2013, ' SynSysNet : integration of experimental data on synaptic protein-protein interactions with drug-target relations ', Nucleic Acids Research, vol. 41, no. D1, pp. D834-D840 . https://doi.org/10.1093/nar/gks1040
Nucleic Acids Research, 41(D1), D834-D840. Oxford University Press
von Eichborn, J, Dunkel, M, Gohlke, B O, Preissner, S C, Hoffmann, M F, Bauer, J M J, Armstrong, J D, Schaefer, M H, Andrade-Navarro, M A, Le Novere, N, Croning, M D R, Grant, S G N, van Nierop, P, Smit, A B & Preissner, R 2013, ' SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations ', Nucleic Acids Research, vol. 41, no. D1, pp. D834-D840 . https://doi.org/10.1093/nar/gks1040
Nucleic Acids Research
von Eichborn, J, Dunkel, M, Gohlke, B O, Preissner, S C, Hoffmann, M F, Bauer, J M J, Armstrong, D, Schaefer, M H, Andrade-Navarro, M A, Le Novere, N, Croning, M D R, Grant, S G N, van Nierop, P, Smit, A B & Preissner, R 2013, ' SynSysNet : integration of experimental data on synaptic protein-protein interactions with drug-target relations ', Nucleic Acids Research, vol. 41, no. D1, pp. D834-D840 . https://doi.org/10.1093/nar/gks1040
We created SynSysNet, available online at http://bioinformatics.charite.de/ synsysnet, to provide a platform that creates a comprehensive 4D network of synaptic interactions. Neuronal synapses are fundamental structures linking nerve cells in the bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b88c38b7ffdb49c3384142b8fabac66
Autor:
Saskia Preissner, Mathias Dunkel, Michael F. Hoffmann, Sarah C. Preissner, Robert Preissner, Andreas Gewiess
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e82562 (2013)
PLoS ONE 8 (12): e82562.
PLoS ONE, Vol 8, Iss 12, p e82562 (2013)
PLoS ONE 8 (12): e82562.
The cytochrome P450 (CYP) enzymes are major players in drug metabolism. More than 2,000 mutations have been described, and certain single nucleotide polymorphisms (SNPs) have been shown to have a large impact on CYP activity. Therefore, CYPs play an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e0c1bef13065606964af496ba11358
http://europepmc.org/articles/PMC3858335
http://europepmc.org/articles/PMC3858335
Autor:
Sarah C. Preissner, Saskia Preissner, Robert Preissner, Nikolai Genov, Mathias Dunkel, Wen Wei Rong, K Seeger, Michael F. Hoffmann
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51020 (2012)
PLoS ONE
PLoS ONE
Background: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP). Furthermore, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8b1519986dcf2fc542f93ca88dee18
http://europepmc.org/articles/PMC3517625?pdf=render
http://europepmc.org/articles/PMC3517625?pdf=render
The Class I MAGE proteins are normally expressed only in developing germ cells but are often aberrantly expressed in malignancies, particularly melanoma, making them good therapeutic targets. MAGE proteins promote tumor survival by binding to the RBC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533bbb80301265f1623ead049debb756
https://europepmc.org/articles/PMC3149886/
https://europepmc.org/articles/PMC3149886/
Autor:
Michael F Hoffmann
Publikováno v:
Current Biology. 2:21-22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af1fb3be746db4d2fc5a986957dbbbd6
https://doi.org/10.1016/0960-9822(92)90414-6
https://doi.org/10.1016/0960-9822(92)90414-6