Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Michael F. Emmons"'
Autor:
Michael F. Emmons, Richard L. Bennett, Alberto Riva, Kanchan Gupta, Larissa Anastasio Da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter A. Forsyth, Jonathan D. Licht, Keiran S. M. Smalley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Melanomas can adopt multiple transcriptional states. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity. Here, we identify stress-induced HDAC8 activity as driving melan
Externí odkaz:
https://doaj.org/article/eaa6d6439c614e83a09975f61db4c4e0
Autor:
Michael F. Emmons, Nagaraju Anreddy, Javier Cuevas, Kayla Steinberger, Shengyu Yang, Mark McLaughlin, Ariosto Silva, Lori A. Hazlehurst
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The emergence of drug resistance continues to be a major hurdle towards improving patient outcomes for the treatment of Multiple Myeloma. MTI-101 is a first-in-class peptidomimetic that binds a CD44/ITGA4 containing complex and triggers necr
Externí odkaz:
https://doaj.org/article/1cc53c35c5ad47088696b074a09dc978
Autor:
Lori A. Hazlehurst, Anne E. Cress, Mark L. McLaughlin, Rachid Baz, Rajesh R. Nair, Anthony W. Gebhard, Michael F. Emmons
PDF file - 327K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e4d80a46f1e4f0f48a2074e22df7ff
https://doi.org/10.1158/1535-7163.22497066.v1
https://doi.org/10.1158/1535-7163.22497066.v1
Autor:
Lori A. Hazlehurst, Mark L. McLaughlin, John M. Koomen, Raul F. Argilagos, Michael F. Emmons, Rajesh R. Nair, Priyesh Jain, Anthony W. Gebhard
PDF file - 100K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4cf1db07a2a26702593051934a8752
https://doi.org/10.1158/1535-7163.22497660.v1
https://doi.org/10.1158/1535-7163.22497660.v1
Autor:
Lori A. Hazlehurst, Anne E. Cress, Mark L. McLaughlin, Rachid Baz, Rajesh R. Nair, Anthony W. Gebhard, Michael F. Emmons
We recently reported that the β1 integrin antagonist, referred to as HYD1, induces necrotic cell death in myeloma cell lines as a single agent using in vitro and in vivo models. In this article, we sought to delineate the determinants of sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67324d88e64e58ca3c88cb2b7ac3efac
https://doi.org/10.1158/1535-7163.c.6535488
https://doi.org/10.1158/1535-7163.c.6535488
Autor:
Lori A. Hazlehurst, Mark L. McLaughlin, John M. Koomen, Raul F. Argilagos, Michael F. Emmons, Rajesh R. Nair, Priyesh Jain, Anthony W. Gebhard
PDF file - 903K, Supplementary Figure S1: MTI-101 is more potent in U266 cell line than linear parent peptide and biotinylated peptides still retain bioactivity; Supplementary Figure S2: Biotin-HYD1 binding complex in NCI-H929 and U266 MM cell lines;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70be2e850c73a85497dce9e466ca637d
https://doi.org/10.1158/1535-7163.22497657.v1
https://doi.org/10.1158/1535-7163.22497657.v1
Autor:
Lori A. Hazlehurst, Mark L. McLaughlin, John M. Koomen, Raul F. Argilagos, Michael F. Emmons, Rajesh R. Nair, Priyesh Jain, Anthony W. Gebhard
Our laboratory recently reported that treatment with the d-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma cell lines. Because of the intriguing biological activity and promising in vivo activity of HYD1, we pursued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed3cd763c19815b7f2427753ebe2253
https://doi.org/10.1158/1535-7163.c.6535680
https://doi.org/10.1158/1535-7163.c.6535680
Autor:
Lori A. Hazlehurst, William S. Dalton, Hong-Gong Wang, William T. Kerr, Kit Lam, Raul F. Argilagos, Anne E. Cress, Michael F. Emmons, Rajesh R. Nair
Supplementary Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb1d9e5b7c1bd999451dce00fd66eef
https://doi.org/10.1158/1535-7163.22484849.v1
https://doi.org/10.1158/1535-7163.22484849.v1
Autor:
Keiran S.M. Smalley, J. William Harbour, Jonathan D. Licht, Uwe Rix, Silvya Stuchi Maria-Engler, Srikumar P. Chellappan, John M. Koomen, Bin Fang, Biswarup Saha, Fumi Kinose, Michael A. Durante, Michael F. Emmons, Fernanda Faião-Flores
Supplemental Figure 1: Gene ontology network analysis of uveal melanoma cells following MEKi treatment (24h) and ABPP. Supplemental Figure 2: ET-3 increases nuclear accumulation of YAP in 92.1, Mel270, MP41 and OMM1 cells. Supplemental Figure 3: ET-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7b3c2c75bdf283a97ad482de2b351d
https://doi.org/10.1158/1078-0432.22471901
https://doi.org/10.1158/1078-0432.22471901
Autor:
Keiran S.M. Smalley, J. William Harbour, Jonathan D. Licht, Uwe Rix, Silvya Stuchi Maria-Engler, Srikumar P. Chellappan, John M. Koomen, Bin Fang, Biswarup Saha, Fumi Kinose, Michael A. Durante, Michael F. Emmons, Fernanda Faião-Flores
Supplementary Table S1- Antibodies used for protein expression in western blotting experiments Supplementary Table S2 - Assays used for gene expression in RT-qPCR experiments Supplementary Table S3 - Antibodies used for protein expression in immunofl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b6fa70918d2735b28b48bcd1f4dcb8
https://doi.org/10.1158/1078-0432.22471898
https://doi.org/10.1158/1078-0432.22471898