Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael F. Ciccone"'
Autor:
Iris Munhoz Costa, Brian Effer, Tales Alexandre Costa-Silva, Chen Chen, Michael F. Ciccone, Adalberto Pessoa, Camila O. dos Santos, Gisele Monteiro
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11215 (2023)
L-Asparaginase (ASNase) is a biopharmaceutical used as an essential drug in the treatment of acute lymphoblastic leukemia (ALL). Yet, some cases of ALL are naturally resistant to ASNase treatment, which results in poor prognosis. The REH ALL cell lin
Externí odkaz:
https://doaj.org/article/b00cb899412c45fcb09f63d31569d560
Autor:
Mary J. Feigman, Matthew A. Moss, Chen Chen, Samantha L. Cyrill, Michael F. Ciccone, Marygrace C. Trousdell, Shih-Ting Yang, Wesley D. Frey, John E. Wilkinson, Camila O. dos Santos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mammary epithelial cells are epigenetically modified during pregnancy, these changes can influence the pre-disposition to cancer. Here, the authors examine the epigenetic landscape of mammary epithelial cells pre and post pregnancy and identify chang
Externí odkaz:
https://doaj.org/article/be6daa3b32964ca8879edb8c33935d36
Autor:
Monteiro, Iris Munhoz Costa, Brian Effer, Tales Alexandre Costa-Silva, Chen Chen, Michael F. Ciccone, Adalberto Pessoa, Camila O. dos Santos, Gisele
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11215
L-Asparaginase (ASNase) is a biopharmaceutical used as an essential drug in the treatment of acute lymphoblastic leukemia (ALL). Yet, some cases of ALL are naturally resistant to ASNase treatment, which results in poor prognosis. The REH ALL cell lin
Autor:
Hideki Aihara, Huda Zahid, Marcus Fischer, Ke Shi, Camila O. dos Santos, Ernst Schönbrunn, Manjulata Singh, A. Chan, Joseph W. Landry, Caroline R. Buchholz, Stanley Nithianantham, William C. K. Pomerantz, Michael F. Ciccone
Publikováno v:
J Med Chem
The nucleosome remodeling factor (NURF) alters chromatin accessibility through interactions with its largest subunit,the bromodomain PHD finger transcription factor BPTF. BPTF is overexpressed in several cancers and is an emerging anticancer target.
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
The use of mouse derived mammary organoids can provide a unique strategy to study mammary gland development across a normal life cycle, as well as offering insights into how malignancies form and progress. Substantial cellular and epigenomic changes
Autor:
Shih Ting Yang, Samantha L. Cyrill, Camila O. dos Santos, Wesley D. Frey, John E. Wilkinson, Mary J. Feigman, Michael F. Ciccone, Matthew A. Moss, Chen Chen
Pregnancy leaves a series of cellular and molecular modifications on mammary epithelial cells (MECs). Pregnancy is also known for decreasing the predisposition of rodent and human MECs to oncogenesis. Here, in order to understand the molecular basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cfc0c5c6cef9987f93813f97e5b812
https://doi.org/10.1101/642330
https://doi.org/10.1101/642330
Autor:
Alex Dickson, Hideki Aihara, Mohammed Kashani-Sabet, Junwei Shi, Jorden A. Johnson, Steven E. Kirberger, Ke Shi, Michael F. Ciccone, Peter D. Ycas, Andrew K. Urick, William C. K. Pomerantz, Rinette Woo, Camila O. dos Santos, Sean D. McAllister, Huda Zahid, Chen Chen
Publikováno v:
Organicbiomolecular chemistry. 17(7)
Bromodomain and PHD finger containing protein transcription factor (BPTF) is an epigenetic protein involved in chromatin remodelling and is a potential anticancer target. The BPTF bromodomain has one reported small molecule inhibitor (AU1, rac-1). He
Autor:
Amritha Varshini Hanasoge Somasundara, Matthew A. Moss, Mary J. Feigman, Chen Chen, Samantha L. Cyrill, Michael F. Ciccone, Marygrace C. Trousdell, Macy Vollbrecht, Siran Li, Jude Kendall, Semir Beyaz, John E. Wilkinson, Camila O. dos Santos
Publikováno v:
Cell reports
SUMMARY Pregnancy reprograms mammary epithelial cells (MECs) to control their responses to pregnancy hormone re-exposure and carcinoma progression. However, the influence of pregnancy on the mammary microenvironment is less clear. Here, we used singl
Autor:
Wesley D. Frey, Chen Chen, Mary J. Feigman, Camila O. dos Santos, Matthew A. Moss, Marygrace C. Trousdell, Samantha L. Cyrill, Shih Ting Yang, John E. Wilkinson, Michael F. Ciccone
Publikováno v:
Cancer Research. 80:A09-A09
Pregnancy instates a series of cellular and molecular modifications in the mammary epithelial cells (MECs) of the adult female mammary gland. Pregnancy is also known for decreasing the predisposition of rodent and human MECs to oncogenesis. In order