Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael F. Belcourt"'
Autor:
Peining Li, Fang Lin, Yashang Lee, Joseph G. Cory, Peter M. Glazer, Z. Ping Lin, Alan C. Sartorelli, Michael F. Belcourt
Publikováno v:
Molecular Pharmacology. 80:1000-1012
Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in the production of deoxyribonucleoside triphosphates (dNTPs) required for replicative and repair DNA synthesis. Mammalian RNR is a heteromeric enzyme consisting primarily of R1 and R2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216a9782297b131fc87f39d0bda2abf6
https://doi.org/10.1124/mol.111.074708
https://doi.org/10.1124/mol.111.074708
Autor:
Philip G. Penketh, David H. Sherman, William F. Hodnick, Krishnamurthy Shyam, Michael F. Belcourt, Alan C. Sartorelli
Publikováno v:
Journal of Biological Chemistry. 276:34445-34452
Mitomycin C requires reductive activation to cross-link DNA and express anticancer activity. Reduction of mitomycin C (40 microm) by sodium borohydride (200 microm) in 20 mm Tris-HCl, 1 mm EDTA at 37 degrees C, pH 7.4, gives a 50-60% yield of the rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4249f4b654232581ca843188d16d13b3
https://doi.org/10.1074/jbc.m104263200
https://doi.org/10.1074/jbc.m104263200
Autor:
Sara Rockwell, Li-Qun Tang, Michael F. Belcourt, Alan C. Sartorelli, Chris A. Pritsos, Yolanda Palom, Maria Tomasz, Shilpi S Mehta, Karen L. Pritsos
Publikováno v:
Biochemical Pharmacology. 61:1517-1529
The six DNA adducts formed in EMT6 mouse mammary tumor cells upon treatment with mitomycin C (MC) fall into two groups: (1) four guanine adducts of MC and (2) two guanine adducts derived from 2,7-diaminomitosene (2,7-DAM), the major reductive metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b744f2d9aed7954b08e1783553fa6b7
https://doi.org/10.1016/s0006-2952(01)00609-8
https://doi.org/10.1016/s0006-2952(01)00609-8
Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA
Autor:
Philip G. Penketh, Sara Rockwell, Michael F. Belcourt, David H. Sherman, William F. Hodnick, David A. Johnson, Alan C. Sartorelli
Publikováno v:
Proceedings of the National Academy of Sciences. 96:10489-10494
The mitomycin C-resistance gene, mcrA , of Streptomyces lavendulae produces MCRA, a protein that protects this microorganism from its own antibiotic, the antitumor drug mitomycin C. Expression of the bacterial mcrA gene in mammalian Chinese hamster o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078d4fdd740bcee122e14436ca1f242f
https://doi.org/10.1073/pnas.96.18.10489
https://doi.org/10.1073/pnas.96.18.10489
Publikováno v:
Biochemical Pharmacology. 51:1669-1678
DT-Diaphorase catalyzes a two-electron reduction of mitomycin C (MC) and porfiromycin (POR) to reactive species. Many cell lines that overexpress DT-diaphorase and are sensitive to the mitomycins are protected from the aerobic cytotoxicity of these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f57169630a4f57bb6df704ff4f1505
https://doi.org/10.1016/0006-2952(96)00143-8
https://doi.org/10.1016/0006-2952(96)00143-8
Publikováno v:
Cell
Ribosomal frameshifting regulates expression of the TYB gene of yeast Ty retrotransposons. We previously demonstrated that a 14 nucleotide sequence conserved between two families of Ty elements was necessary and sufficient to support ribosomal frames
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95a05a43fed3e80c639b85d197ea4cd
Autor:
Philip G. Penketh, Sara Rockwell, Maria Tomasz, Alan C. Sartorelli, Helen A. Seow, Michael F. Belcourt, William F. Hodnick
Publikováno v:
Molecular pharmacology. 67(2)
Overexpression of endoplasmic reticulum-localized NADPH: cytochrome c (P450) reductase (NPR) in Chinese hamster ovary cells increases the hypoxic/aerobic differential toxicity of the mitomycins. Because considerable evidence indicates that DNA cross-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bb2c71c55e0390952a79dde28ebc20
https://pubmed.ncbi.nlm.nih.gov/15547247
https://pubmed.ncbi.nlm.nih.gov/15547247
Autor:
Alan C. Sartorelli, Helen A. Seow, Philip G. Penketh, Michael F. Belcourt, Maria Tomasz, Sara Rockwell
Publikováno v:
The Journal of biological chemistry. 279(30)
The effects of the subcellular localization of overexpressed bioreductive enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) on the activity of the antineoplastic agent mitomycin C (MC) under aerobic and hypoxic conditions were examined. Chinese hamster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d315945e68ae25ab703599d8344c03
https://pubmed.ncbi.nlm.nih.gov/15155746
https://pubmed.ncbi.nlm.nih.gov/15155746
Autor:
Maria Tomasz, Alan C. Sartorelli, Steven M. Musser, Michael F. Belcourt, Yolanda Palom, Sara Rockwell
Publikováno v:
Chemical research in toxicology. 13(6)
Treatment of EMT6 mouse mammary tumor cells with mitomycin C (MC) results in the formation of six major MC-DNA adducts. We identified the last unknown of these ("adduct X") as a guanine N(2) adduct of 2, 7-diaminomitosene (2,7-DAM), in which the mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5188e6d6b2ef2dc176c75be9354ee67c
https://pubmed.ncbi.nlm.nih.gov/10858321
https://pubmed.ncbi.nlm.nih.gov/10858321
Autor:
Regina Loomis, Krishnamurthy Shyam, Alan C. Sartorelli, Sara Rockwell, Maxim Shapiro, Michael F. Belcourt, Philip G. Penketh
Publikováno v:
Journal of medicinal chemistry. 42(5)
Some 4- and 2-(nitrobenzyloxycarbonyl)-1, 2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines (4, 6, and 7) were synthesized and evaluated for their ability to exert preferential toxicity to hypoxic EMT6 mammary carcinoma cells using a colony-forming a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7feb9637d41a444ab85f8020ffc8deed
https://pubmed.ncbi.nlm.nih.gov/10072691
https://pubmed.ncbi.nlm.nih.gov/10072691