Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Michael F. Allard"'
Autor:
Richard B. Wambolt, Varun Saran, Vivek Sharma, Michael F. Allard, Violet G. Yuen, John H. McNeill
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 92:827-837
Metabolic disturbances and oxidative stress have been highlighted as potential causative factors for the development of diabetic cardiomyopathy. The β-blocker metoprolol is known to improve function in the diabetic rat heart and ameliorates the sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89fd21f48571c314b44859510ddcd38
https://doi.org/10.1139/cjpp-2014-0078
https://doi.org/10.1139/cjpp-2014-0078
Autor:
Dan S. Luciani, Varun Saran, Farnaz Taghizadeh, Scott B. Widenmaier, James D. Johnson, Sarah A. White, Michael F. Allard, Xiaoke Hu
Publikováno v:
Diabetes. 62:170-182
B-cell lymphoma 2 (Bcl-2) family proteins are established regulators of cell survival, but their involvement in the normal function of primary cells has only recently begun to receive attention. In this study, we demonstrate that chemical and genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65fbc642b320f66fe405fc0b85644af4
https://doi.org/10.2337/db11-1464
https://doi.org/10.2337/db11-1464
Autor:
Donald McAfee, James D. Johnson, Leonard J. Foster, S. R. Wayne Chen, Edwin D.W. Moore, Parisa Asghari, Nichollas E. Scott, Rich Wambolt, Michael F. Allard, Razvan F. Albu, Jerzy E. Kulpa, Thibault Mayor, Lubos Bohunek, Haoning Cen, Michael J. Bround, Christoph H. Borchers, Jun Han, Marc Pourrier, Roger W. Brownsey, David Fedida
Publikováno v:
The Journal of biological chemistry. 291(45)
Cardiac ryanodine receptor (Ryr2) Ca2+ release channels and cellular metabolism are both disrupted in heart disease. Recently, we demonstrated that total loss of Ryr2 leads to cardiomyocyte contractile dysfunction, arrhythmia, and reduced heart rate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887e34396318750f5977c7d4d9e61d5e
https://pubmed.ncbi.nlm.nih.gov/27621312
https://pubmed.ncbi.nlm.nih.gov/27621312
Autor:
Margaret A. Knowling, Michael F. Allard, Dennis R. Grant, Lise Matzke, Andrew Ignaszewski, Jonathon Leipsic, James B. Cupples
Publikováno v:
Cardiovascular Pathology. 20:e197-e201
Primary cardiac angiosarcoma is a rare neoplasm and the epithelioid variant is exceedingly rare. We report a case of an epithelioid angiosarcoma that involved the right atrium and aorta of a 47-year-old male. The patient presented with atrial fibrill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e064de365466677988f3fe27be2b4230
https://doi.org/10.1016/j.carpath.2010.09.006
https://doi.org/10.1016/j.carpath.2010.09.006
Publikováno v:
Journal of Histotechnology. 33:182-186
Evaluation of vascular responses to metallic stent implantation is essential in the setting of vascular disease. Study of the vascular response to stent implantation has been hampered by difficulties in sectioning metal and tissue without distortion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c77fd79e578e3cf4d248ac564f04aa
https://doi.org/10.1179/his.2010.33.4.182
https://doi.org/10.1179/his.2010.33.4.182
Autor:
Wendy A. Boivin, Alon Hendel, Sarah J. Williams, David J. Granville, Lisa S. Ang, Michael F. Allard, Hongyan Zhao, Ciara M. Chamberlain, Dawn Cooper, Maggie Folkesson, Bruce M. McManus, Jesper Swedenborg
Publikováno v:
The American Journal of Pathology; Vol 176
Granzyme B (GZMB) is a serine protease that is abundantly expressed in advanced human atherosclerotic lesions and may contribute to plaque instability. Perforin is a pore-forming protein that facilitates GZMB internalization and the induction of apop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88113244ce26c6b93bd682bc52938f3
Publikováno v:
Journal of Histotechnology. 32:151-154
Intravascular placement of metallic stents is a common treatment of stenosed coronary arteries; however, they are associated with risk of in-stent restenosis and late-stent thrombosis. Pathological evaluation of stented coronary arteries is needed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed6f3f78ece014d5b3ffbe5bbd32d020
https://doi.org/10.1179/his.2009.32.4.151
https://doi.org/10.1179/his.2009.32.4.151
Autor:
Stephanie Thorn, Michael H. Gollob, István Baczkó, Robert Roberts, Karalyn D. Folmes, Debby P.Y. Koonen, Anita Y.M. Chan, Beth E. Hunter, Jason R.B. Dyck, Thomas Pulinilkunnil, Peter E. Light, Michael F. Allard
Publikováno v:
Circulation: Cardiovascular Genetics. 2:457-466
Background— Humans with an R302Q mutation in AMPKγ 2 (the PRKAG2 gene) develop a glycogen storage cardiomyopathy characterized by a familial form of Wolff-Parkinson-White syndrome and cardiac hypertrophy. This phenotype is recapitulated in transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fee65fc5f2af379bd0b95dfba545eb7
https://doi.org/10.1161/circgenetics.108.834564
https://doi.org/10.1161/circgenetics.108.834564
Autor:
John H. McNeill, Natasha Patel, Richard W Wambolt, Sally Mustafa, Michael F. Allard, Vivek Sharma
Publikováno v:
European Journal of Pharmacology. 617:113-117
Leptin has previously been shown to stimulate fatty acid oxidation independent of AMP-activated protein kinase (AMPK). Nitric oxide and p38 mitogen activated protein kinase (MAPK) are known effectors of leptin signaling. The aim of the present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d323c4784c3cd4d650e0faafca1db19f
https://doi.org/10.1016/j.ejphar.2009.06.037
https://doi.org/10.1016/j.ejphar.2009.06.037
Autor:
Varun Saran, Richard B. Wambolt, Jason R.B. Dyck, Annie P. K. Chan, Michael F. Allard, Ramesh Saeedi, Sherry S. Y. Wu, Erika S. Kume, Hannah Parsons, Roger W. Brownsey, Kim Paulson
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 296:H1822-H1832
Substrate use switches from fatty acids toward glucose in pressure overload-induced cardiac hypertrophy with an acceleration of glycolysis being characteristic. The activation of AMP-activated protein kinase (AMPK) observed in hypertrophied hearts pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae46f16326206991a1b01b07466616c2
https://doi.org/10.1152/ajpheart.00396.2008
https://doi.org/10.1152/ajpheart.00396.2008