Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Michael F. Moran"'
Autor:
Markus Eszlinger, Alexandra Stephenson, Shideh Mirhadi, Konrad Patyra, Michael F Moran, Moosa Khalil, Jukka Kero, Ralf Paschke
Publikováno v:
European Thyroid Journal, Vol 12, Iss 6, Pp 1-13 (2023)
Objective: Nonautoimmune hyperthyroidism (NAH) is rare and occurs due to a constitutively activating thyroid stimulating hormone receptor (TSHR) mutation. In contrast to other thyroid nodules, no further evaluation for malignancy is recommended for h
Externí odkaz:
https://doaj.org/article/ec09ffec7d2645cb934c4d925b01088d
Autor:
Shideh Mirhadi, Shirley Tam, Quan Li, Nadeem Moghal, Nhu-An Pham, Jiefei Tong, Brian J. Golbourn, Jonathan R. Krieger, Paul Taylor, Ming Li, Jessica Weiss, Sebastiao N. Martins-Filho, Vibha Raghavan, Yasin Mamatjan, Aafaque A. Khan, Michael Cabanero, Shingo Sakashita, Kugeng Huo, Sameer Agnihotri, Kota Ishizawa, Thomas K. Waddell, Gelareh Zadeh, Kazuhiro Yasufuku, Geoffrey Liu, Frances A. Shepherd, Michael F. Moran, Ming-Sound Tsao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
With non-small cell lung cancer (NSCLC) being the leading cause of cancer deaths worldwide, the development of targeted therapies remains crucial. Here, the generation and multi-omics characterization of 137 NSCLC patient-derived xenografts provides
Externí odkaz:
https://doaj.org/article/ca6f25a2b4ee419cb65ec4d91e659e4f
Autor:
Yoshinori Matsumoto, Ioannis D. Dimitriou, Jose La Rose, Melissa Lim, Susan Camilleri, Napoleon Law, Hibret A. Adissu, Jiefei Tong, Michael F. Moran, Andrzej Chruscinski, Fang He, Yosuke Asano, Takayuki Katsuyama, Ken-ei Sada, Jun Wada, Robert Rottapel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Dysregulation of Toll-like receptor (TLR) signaling contributes to the pathogenesis of autoimmune diseases. Here, we provide genetic evidence that tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family, negatively regulates TLR2 signali
Externí odkaz:
https://doaj.org/article/d2045dec99b448209b92c04adaeb7994
Autor:
Jiefei Tong, Jonathan R Krieger, Paul Taylor, Rick Bagshaw, Jae Kang, Swathi Jeedigunta, Leanne E Wybenga-Groot, Wen Zhang, Heba Badr, Shideh Mirhadi, Nhu-An Pham, Étienne Coyaud, Man Yu, Ming Li, Michael Cabanero, Brian Raught, Jason T Maynes, Cynthia Hawkins, Ming Sound Tsao, Michael F Moran
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237981 (2020)
Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers. In order to better understand the role of SHMT2 in cancer a model
Externí odkaz:
https://doaj.org/article/c7f34d407c984a35b79c0dc38739259f
Autor:
Mandeep K. Gill, Tania Christova, Ying Y. Zhang, Alex Gregorieff, Liang Zhang, Masahiro Narimatsu, Siyuan Song, Shawn Xiong, Amber L. Couzens, Jiefei Tong, Jonathan R. Krieger, Michael F. Moran, Alexandre R. Zlotta, Theodorus H. van der Kwast, Anne-Claude Gingras, Frank Sicheri, Jeffrey L. Wrana, Liliana Attisano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional
Externí odkaz:
https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc
Autor:
Shideh Mirhadi, Wen Zhang, Nhu-An Pham, Fereshteh Karimzadeh, Melania Pintilie, Jiefei Tong, Paul Taylor, Jonathan Krieger, Bethany Pitcher, Jenna Sykes, Leanne Wybenga-Groot, Christopher Fladd, Jing Xu, Tao Wang, Michael Cabanero, Ming Li, Jessica Weiss, Shingo Sakashita, Olga Zaslaver, Man Yu, Amy A. Caudy, Julie St-Pierre, Cynthia Hawkins, Thomas Kislinger, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao, Michael F. Moran
Publikováno v:
Molecular Cancer Research. 21:36-50
The ability of a patient tumor to engraft an immunodeficient mouse is the strongest known independent indicator of poor prognosis in early-stage non–small cell lung cancer (NSCLC). Analysis of primary NSCLC proteomes revealed low-level expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9826bec9a7b213aeab12d09becdd053c
https://doi.org/10.1158/1541-7786.mcr-22-0163
https://doi.org/10.1158/1541-7786.mcr-22-0163
Autor:
Jinglin L. Xie, Longguang Qin, Zhengqiang Miao, Ben T. Grys, Jacinto De La Cruz Diaz, Kenneth Ting, Jonathan R. Krieger, Jiefei Tong, Kaeling Tan, Michelle D. Leach, Troy Ketela, Michael F. Moran, Damian J. Krysan, Charles Boone, Brenda J. Andrews, Anna Selmecki, Koon Ho Wong, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Cas5 is a transcriptional regulator of responses to cell wall stress in the fungal pathogen Candida albicans. Here, Xie et al. show that Cas5 also modulates cell cycle dynamics and responses to antifungal drugs.
Externí odkaz:
https://doaj.org/article/ffb813afe4d54f829962b3863b93dbc3
Autor:
Yujia Xu, Zubin Zhang, Jie Li, Jiefei Tong, Biyin Cao, Paul Taylor, Xiaowen Tang, Depei Wu, Michael F. Moran, Yuanying Zeng, Xinliang Mao
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background UBE2O is proposed as a ubiquitin-conjugating enzyme, but its function was largely unknown. Methods Mass spectrometry was applied to identify c-Maf ubiquitination-associated proteins. Immunoprecipitation was applied for c-Maf and U
Externí odkaz:
https://doaj.org/article/c69063e4d34e40e1a2a53279706f4a78
Autor:
Robert Siddaway, Laura Canty, Sanja Pajovic, Scott Milos, Etienne Coyaud, Stefanie-Grace Sbergio, Arun Kumaran Vadivel Anguraj, Evan Lubanszky, Hwa Young Yun, Alessia Portante, Sheyenne Carette, Cunjie Zhang, Michael F. Moran, Brian Raught, Eric I. Campos, Cynthia Hawkins
Publikováno v:
Acta Neuropathologica. 144:1027-1048
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f5f269c7f1ee60e04e95b904bf0b3b
https://doi.org/10.1007/s00401-022-02489-2
https://doi.org/10.1007/s00401-022-02489-2
Autor:
Michael F. Moran, Ming Sound Tsao, Thomas Kislinger, Bradly G. Wouters, Brian Raught, Geoffrey Liu, Nhu-An Pham, Jiefei Tong, Paul Taylor, Jonathan R. Krieger, Lei Li, Vladimir Ignatchenko, Étienne Coyaud, Ravi N. Vellanki, Yuhong Wei
Figure S1. Expression of CHCHD2 and EGFR in NSCLC cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c1af1f6fcf4e73d55f95d97d342c06
https://doi.org/10.1158/1541-7786.22510962
https://doi.org/10.1158/1541-7786.22510962
