Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Michael F. McDermott"'
Autor:
Heledd H Jarosz-Griffiths, Lindsey Gillgrass, Laura R Caley, Giulia Spoletini, Ian J Clifton, Christine Etherington, Sinisa Savic, Michael F McDermott, Daniel Peckham
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0304555 (2024)
Inflammation is a key driver in the pathogenesis of cystic fibrosis (CF). We assessed the effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on downregulating systemic and immune cell-derived inflammatory cytokines. We also monitored the
Externí odkaz:
https://doaj.org/article/caa59c7e9d2246b8a30553c4cecf4594
Autor:
Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James Poulter, David G. Kent, Sinisa Savic, on behalf of the ImmunAID consortium
Publikováno v:
HemaSphere, Vol 7, Iss 8, p e934 (2023)
Externí odkaz:
https://doaj.org/article/d91f072a395a4835b1c491213ce371f7
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 42 (2024)
Rheumatoid arthritis (RA) is a relatively common systemic autoimmune disease with an estimated prevalence of approximately 1% worldwide. Patients present predominantly with symmetrical small joint inflammatory arthritis, which involves dysregulated i
Externí odkaz:
https://doaj.org/article/ce8cb71f03884f66bac84400e2187148
Autor:
Samuel Lara‐Reyna, Emily A Caseley, Joanne Topping, François Rodrigues, Jorge Jimenez Macias, Sean E Lawler, Michael F McDermott
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 7, Pp n/a-n/a (2022)
Abstract Inflammasomes are assembled by innate immune sensors that cells employ to detect a range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes activate inflammatory caspases, which trigger a cascade of molecular eve
Externí odkaz:
https://doaj.org/article/01c642d3ce5a4c1a81bf365f2cefa4d8
Autor:
Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Michael F. McDermott
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue. These diseases are characterised by a progressive neuronal loss in the brain or p
Externí odkaz:
https://doaj.org/article/2c93e60cfc644780a68c2a7a589e88bd
Autor:
Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulato
Externí odkaz:
https://doaj.org/article/e72e404e8886401f9e9b651bbc12b5a4
Autor:
Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott
Publikováno v:
eLife, Vol 8 (2019)
Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium c
Externí odkaz:
https://doaj.org/article/4da6ca1aca8646a0aba1a7636105b237
Autor:
Samuel Lara-Reyna, Thomas Scambler, Jonathan Holbrook, Chi Wong, Heledd H. Jarosz-Griffiths, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F. McDermott
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cystic Fibrosis (CF) is a recessive genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR mutations cause dysregulation of channel function with intracellular accumulation of misfolded proteins a
Externí odkaz:
https://doaj.org/article/f225fc1ab25740098c9d3164db1b5f47
Autor:
Stephanie R. Harrison, Thomas Scambler, Lylia Oubussad, Chi Wong, Miriam Wittmann, Michael F. McDermott, Sinisa Savic
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Tumor necrosis factor (TNF)-receptor-associated periodic fever syndrome (TRAPS) is a rare monogenic autoinflammatory disorder characterized by mutations in the TNFRSF1A gene, causing TNF-receptor 1 (TNFR1) misfolding, increased cellular stress, activ
Externí odkaz:
https://doaj.org/article/dcb9cc578b094ab887af9e11405f9096
Autor:
Sinisa Savic, Fatima Nadat, Michael F. McDermott, Samuel Lara-Reyna, Clive Carter, James A. Poulter, Joanne Topping, Gavin P. Spickett, Emily A. Caseley
Publikováno v:
Journal of Clinical Immunology
The NLRP3 inflammasome is a vital mediator of innate immune responses. There are numerous NLRP3 mutations that cause NLRP3-associated autoinflammatory diseases (NLRP3-AIDs), mostly in or around the NACHT domain. Here, we present a patient with a rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cbfe128610f240d089259051a59eb5
http://europepmc.org/articles/PMC8528658
http://europepmc.org/articles/PMC8528658