Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Michael F Olson"'
Autor:
Linda Julian, Gregory Naylor, Grant R Wickman, Nicola Rath, Giovanni Castino, David Stevenson, Sheila Bryson, June Munro, Lynn McGarry, Margaret Mullin, Alistair Rice, Armandodel Del Río Hernández, Michael F Olson
Publikováno v:
eLife, Vol 10 (2021)
Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase non-cleavable (ROCK1nc) by mutating aspartate 1113, which rev
Externí odkaz:
https://doaj.org/article/561313de3fc74efb82322845873c5ee6
Autor:
Katerina Mardilovich, Gregory Naylor, Linda Julian, Narisa Phinichkusolchit, Karen Keeshan, Karen Blyth, Michael F. Olson
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/48c60a7914734ffa8fb50ad8a03f0b2c
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17143 (2011)
A common goal for potential cancer therapies is the identification of differences in protein expression or activity that would allow for the selective targeting of tumor vs. normal cells. The Ras proto-oncogene family (K-Ras, H-Ras and N-Ras) are amo
Externí odkaz:
https://doaj.org/article/6d022cebf6814d7dbac57ceca94475b0
Autor:
Timo Heikkila, Edward Wheatley, Diane Crighton, Ewald Schroder, Alexandra Boakes, Sarah J Kaye, Mokdad Mezna, Leon Pang, Mathew Rushbrooke, Andrew Turnbull, Michael F Olson
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24825 (2011)
MRCKα and MRCKβ (myotonic dystrophy kinase-related Cdc42-binding kinases) belong to a subfamily of Rho GTPase activated serine/threonine kinases within the AGC-family that regulate the actomyosin cytoskeleton. Reflecting their roles in myosin light
Externí odkaz:
https://doaj.org/article/2cc27aa9fe3442bd86351f46f0227c37
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/d2bcda7c3ada407d9c24bc40ad0c306e
Autor:
Garett Armstrong, Michael F. Olson
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 3, Pp 151257- (2022)
The role of the actin cytoskeleton during receptor-mediated endocytosis (RME) has been well characterized in yeast for many years. Only more recently has the interplay between the actin cytoskeleton and RME been extensively explored in mammalian cell
Externí odkaz:
https://doaj.org/article/c584c341c97e49298717e69bc4d89f9f
Autor:
Vanessa M. Ruscetta, Taj J. Seaton, Aleen Shakeel, Stanley N. S. Vasconcelos, Russell D. Viirre, Marc J. Adler, Michael F. Olson
Publikováno v:
Cells, Vol 12, Iss 4, p 534 (2023)
Cytoskeleton organization and dynamics are rapidly regulated by post-translational modifications of key target proteins. Acting downstream of the Cdc42 GTPase, the myotonic dystrophy-related Cdc42-binding kinases MRCKα, MRCKβ, and MRCKγ have recen
Externí odkaz:
https://doaj.org/article/d9d3e7e172be471baceb587bc7309f2f
Autor:
Michael F. Olson
Publikováno v:
Cells, Vol 12, Iss 1, p 9 (2022)
The shape and load bearing strength of cells are determined by the complex protein network comprising the actin-myosin cytoskeleton [...]
Externí odkaz:
https://doaj.org/article/78fb45b5afea4f6cbacc1de6c4d16cba
Autor:
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C.E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689- (2021)
Summary: Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (
Externí odkaz:
https://doaj.org/article/60a7564e516e42fe894cc587d92fc98e
Autor:
Michael F. Olson, Joanne Edwards, Emma Shanks, Rachana Patel, Clare Orange, Lynn McGarry, Mads Gabrielsen, Katerina Mardilovich
Supplementary Figure S1: Antibody validation data, disease free progression data, and LIMK1, LIMK2 and metalloproteinase protein expression data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177a1ecceb6d8503fedbd75fc7d63cca
https://doi.org/10.1158/1535-7163.22501720.v1
https://doi.org/10.1158/1535-7163.22501720.v1