Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Michael F Criscitiello"'
Autor:
Jeannine A Ott, Caitlin D Castro, Thaddeus C Deiss, Yuko Ohta, Martin F Flajnik, Michael F Criscitiello
Publikováno v:
eLife, Vol 7 (2018)
Since the discovery of the T cell receptor (TcR), immunologists have assigned somatic hypermutation (SHM) as a mechanism employed solely by B cells to diversify their antigen receptors. Remarkably, we found SHM acting in the thymus on α chain locus
Externí odkaz:
https://doaj.org/article/14c749873076466f9d90b7918cf13475
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005731 (2016)
Externí odkaz:
https://doaj.org/article/d1f9b8cb3e224e82812d2479b7b4b8af
Autor:
Alisa H. Isaac, Sarea Y. Recalde Phillips, Elizabeth Ruben, Matthew Estes, Varsha Rajavel, Talia Baig, Carol Paleti, Kirsten Landsgaard, Ryang Hwa Lee, Teja Guda, Michael F. Criscitiello, Carl Gregory, Daniel L. Alge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract While poly(ethylene glycol) (PEG) hydrogels are generally regarded as biologically inert blank slates, concerns over PEG immunogenicity are growing, and the implications for tissue engineering are unknown. Here, we investigate these implicat
Externí odkaz:
https://doaj.org/article/d2a01dd23c6b4355ac9ac54e2f68a0ef
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003110 (2013)
Externí odkaz:
https://doaj.org/article/dc39887ca6a14d74bdfece0cb6c48c85
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003402 (2013)
Externí odkaz:
https://doaj.org/article/b4ebed10541140a59e99743e6312fe8a
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Comparative animal models generate fundamental scientific knowledge of immune responses. However, these studies typically are conducted in mammals because of their biochemical and physiological similarity to humans. Presently, there has been an inter
Externí odkaz:
https://doaj.org/article/2821550cf8c845cb8c3c70b8af96fef0
Autor:
Jeannine A. Ott, Jeremy K. Haakenson, Abigail R. Kelly, Claire Christian, Michael F. Criscitiello, Vaughn V. Smider
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In the mammalian immune system, the surrogate light chain (SLC) shapes the antibody repertoire during B cell development by serving as a checkpoint for production of functional heavy chains (HC). Structural studies indicate that tail regions of VpreB
Externí odkaz:
https://doaj.org/article/be2d465e729c447ebc5209b913d1b86a
Autor:
Jeannine A. Ott, Christian Mitchell, Morgan Sheppard, Thad C. Deiss, J. M. Cody Horton, Jeremy K. Haakenson, Ruiqi Huang, Abigail R. Kelley, Brian W. Davis, James N. Derr, Vaughn V. Smider, Michael F. Criscitiello
Publikováno v:
Immunogenetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087bba0250895a5fbf1af3d1f0b2c893
https://doi.org/10.1007/s00251-023-01305-9
https://doi.org/10.1007/s00251-023-01305-9
Publikováno v:
Immunogenetics
Immunoglobulins and T cell receptors (TCR) have obvious structural similarities as well as similar immunogenetic diversification and selection mechanisms. Nevertheless, the two receptor systems and the loci that encode them are distinct in humans and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98457dd571eadbf915928a0b4c11cff6
https://doi.org/10.1007/s00251-020-01183-5
https://doi.org/10.1007/s00251-020-01183-5
Publikováno v:
Eur J Immunol
In addition to canonical TCR and BCR, cartilaginous fish assemble noncanonical TCR that employ various B-cell components. For example, shark T cells associate alpha (TCR-α) or delta (TCR-δ) constant (C) regions with Ig heavy chain (H) variable (V)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ba1a68caae4cb5ca6da53a36a15c34
https://doi.org/10.1002/eji.201948495
https://doi.org/10.1002/eji.201948495