Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy.

Autor: Manu N Capoor, Filip Ruzicka, Jonathan E Schmitz, Garth A James, Tana Machackova, Radim Jancalek, Martin Smrcka, Radim Lipina, Fahad S Ahmed, Todd F Alamin, Neel Anand, John C Baird, Nitin Bhatia, Sibel Demir-Deviren, Robert K Eastlack, Steve Fisher, Steven R Garfin, Jaspaul S Gogia, Ziya L Gokaslan, Calvin C Kuo, Yu-Po Lee, Konstantinos Mavrommatis, Elleni Michu, Hana Noskova, Assaf Raz, Jiri Sana, A Nick Shamie, Philip S Stewart, Jerry L Stonemetz, Jeffrey C Wang, Timothy F Witham, Michael F Coscia, Christof Birkenmaier, Vincent A Fischetti, Ondrej Slaby

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0174518 (2017)

BACKGROUND:In previous studies, Propionibacterium acnes was cultured from intervertebral disc tissue of ~25% of patients undergoing microdiscectomy, suggesting a possible link between chronic bacterial infection and disc degeneration. However, given

Externí odkaz: https://doaj.org/article/d08e62daa8a74ed49b602d466cbb3588

Sheep as a Potential Model of Intradiscal Infection by the Bacterium Cutibacterium acnes

Autor: Erin C. Coscia, Nader S. Abutaleb, Bradley Hostetter, Mohamed N. Seleem, Gert J. Breur, Robyn R. McCain, Christa J. Crain, Ondrej Slaby, Manu N. Capoor, Andrew McDowell, Fahad S. Ahmed, Viju Vijayanpillai, Sanjeev K. Narayanan, Michael F. Coscia

Publikováno v: Veterinary Sciences, Vol 8, Iss 3, p 48 (2021)

The anaerobic bacterium Cutibacterium acnes has been increasingly linked to the development of degenerative disc disease (DDD), although causality is yet to be conclusively proven. To better study how this organism could contribute to the aetiology o

Externí odkaz: https://doaj.org/article/861a0c02ae7c425093ce29f874f0b090

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Autor: Steven R. Garfin, Christof Birkenmaier, A. Nick Shamie, Radim Jančálek, Andrew McDowell, Michael F. Coscia, Manu N. Capoor, Jeffrey C. Wang, Martin Smrčka, Martin Solansky, Todd Alamin, Ondrej Slaby, Filip Ruzicka, Jan Lochman, Martina Zapletalová, Jonathan E. Schmitz

Publikováno v: European Spine Journal. 28:783-791

The presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2844d4912b7745694c044428ca1352
https://doi.org/10.1007/s00586-018-5838-z

Sheep as a Potential Model of Intradiscal Infection by the Bacterium Cutibacterium acnes

Autor: Andrew McDowell, Bradley Hostetter, Erin C Coscia, Mohamed N. Seleem, Michael F. Coscia, Robyn R. McCain, Manu N. Capoor, Gert J. Breur, Nader S. Abutaleb, Viju Vijayanpillai, Christa J Crain, Fahad S. Ahmed, Ondrej Slaby, Sanjeev K. Narayanan

Publikováno v: Veterinary Sciences
Veterinary Sciences, Vol 8, Iss 48, p 48 (2021)

The anaerobic bacterium Cutibacterium acnes has been increasingly linked to the development of degenerative disc disease (DDD), although causality is yet to be conclusively proven. To better study how this organism could contribute to the aetiology o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3bbb4825bd4f6fbd177ef1fe5707b6
https://doi.org/10.3390/vetsci8030048

Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy

Autor: Radim Lipina, Garth A. James, Ondrej Slaby, John C. Baird, Jiri Sana, Nitin N. Bhatia, Christof Birkenmaier, Jeffrey C. Wang, A. Nick Shamie, Assaf Raz, Robert K. Eastlack, Jerry Stonemetz, Filip Ruzicka, Steven R. Garfin, Neel Anand, Elleni Michu, Jonathan E. Schmitz, Philip S. Stewart, Radim Jančálek, Jaspaul S. Gogia, Vincent A. Fischetti, Tana Machackova, Konstantinos Mavrommatis, Michael F. Coscia, Fahad S. Ahmed, Steve T. Fisher, Hana Nosková, Timothy F. Witham, Yu-Po Lee, Manu N. Capoor, Ziya L. Gokaslan, Martin Smrčka, Calvin C. Kuo, Todd Alamin, Sibel Demir-Deviren

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0174518 (2017)
PLoS ONE
Capoor, Manu N; Ruzicka, Filip; Schmitz, Jonathan E; James, Garth A; Machackova, Tana; Jancalek, Radim; et al.(2017). Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy.. PloS one, 12(4), e0174518-e01745e0174518. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/8qn97751

Background In previous studies, Propionibacterium acnes was cultured from intervertebral disc tissue of similar to 25% of patients undergoing microdiscectomy, suggesting a possible link between chronic bacterial infection and disc degeneration. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6a5a2b81d6a470589f8ce8eb8caf9e
http://europepmc.org/articles/PMC5378350?pdf=render