Výsledky vyhledávání - "Michael Fäcke"

Analysis of Protein Expression and Virus-like Particle Formation in Mammalian Cell Lines Stably Expressing HIV-1 gag and env Gene Products with or without Active HIV Proteinase

Autor: Valerie Bosch, Hans-Georg Kräusslich, Christina Ochsenbauer, Klaus Mergener, Anke-Mareil Traenckner, Michael Fäcke, Hans Gelderblom

Publikováno v: Virology. 192:605-617

Cell lines stably releasing noninfectious virus-like particles containing wild type or mutant gene products represent useful tools for a biochemical, immunological, and structural analysis of virus assembly. Human immunodeficiency virus (HIV) type 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c721b1a8f7df4fe53c0a450f44d77de9
https://doi.org/10.1006/viro.1993.1077

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Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220

Autor: Hans-Georg Kräusslich, Christopher U.T. Hellen, Michael Fäcke, Chong-Kyo Lee, Eckard Wimmer

Publikováno v: Journal of Virology. 65:4226-4231

The poliovirus proteinase 2A is autocatalytically released from the poliovirus polyprotein by cotranslational cleavage at its own amino terminus, resulting in separation of structural and nonstructural protein precursors. Cleavage is a prerequisite f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5613fcd3c9aba61bbc62d2b625a721cb
https://doi.org/10.1128/jvi.65.8.4226-4231.1991

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A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulum

Autor: Michael Fäcke, Alfred Janetzko, Hans-Georg Kräusslich, Robert L. Shoeman

Publikováno v: Journal of Virology

Morphogenesis of retroviruses involves assembly of the structural Gag and Gag-Pol polyproteins with subsequent budding of the virus particle from the plasma membrane and proteolytic cleavage by the viral proteinase. The matrix (MA) domain, representi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812960371686424a947fdde106b39d73
https://europepmc.org/articles/PMC237885/

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Cell-free translation and proteolytic processing of the hepatitis A virus polyprotein

Autor: Verena Gauss-Müller, Hans-Georg Kräusslich, Dirk Jürgensen, Michael Fäcke, Yuri Kusov

Publikováno v: The Journal of general virology. 74

Virus-encoded proteinase activity of hepatitis A virus (HAV) was studied in vitro. Genomic regions coding for segments of the viral polyprotein were expressed by in vitro transcription and translation in rabbit reticulocyte lysates. Polyproteins tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dc68c2b4755ecbfbc1856e079e0c34
https://pubmed.ncbi.nlm.nih.gov/8385696

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Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells

Autor: Michael Fäcke, Reinhold Welker, Volker Brinkmann, Hans R. Gelderblom, Hans-Georg Krüsslich, Klaus Mergener

Publikováno v: Virology. 186(1)

Segments of the human immunodeficiency virus (HIV) type 1 gag and pol genes and mutants thereof were transiently expressed in mammalian cells. Expression was dependent on the presence of the rev responsive element in cis and the rev protein in trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540dd8b93f3243d21392fcd53a0912ad
https://pubmed.ncbi.nlm.nih.gov/1727601

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