Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael Ensminger"'
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be re
Externí odkaz:
https://doaj.org/article/f7bfb44500064bbfab5f9926b917f7c1
Autor:
Isabel Freund, Stephanie Hehlgans, Daniel Martin, Michael Ensminger, Emmanouil Fokas, Claus Rödel, Markus Löbrich, Franz Rödel
Publikováno v:
Cells, Vol 9, Iss 5, p 1235 (2020)
NIMA (never-in-mitosis gene A)-related kinase 1 (Nek1) is shown to impact on different cellular pathways such as DNA repair, checkpoint activation, and apoptosis. Its role as a molecular target for radiation sensitization of malignant cells, however,
Externí odkaz:
https://doaj.org/article/e98b33590b1545048ede298a07fe41bd
Autor:
Markus Löbrich, Wolf Dietrich Heyer, Sarita Bhetawal, Jie Liu, Andrés Cruz-García, Hang Phuong Le, Marta Llorens-Agost, Richard D. Wood, Anugrah Gawai, Michael Ensminger
Publikováno v:
Nat Cell Biol
Nature cell biology, vol 23, iss 10
Nature cell biology, vol 23, iss 10
BRCA2-mutant cells are defective in homologous recombination, making them vulnerable to the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This concept can be clinically exploited but is currently limited due to ins
Publikováno v:
BIOspektrum. 28:159-161
Mutations in BRCA1 or BRCA2 are associated with breast, ovarian and other cancers. Cells with these mutations are defective in homologous recombination (HR), one of two main processes to repair DNA double-strand breaks (DSBs). Survival of these cells
Publikováno v:
Mol Cell Oncol
Molecular & cellular oncology, vol 8, iss 6
Molecular & cellular oncology, vol 8, iss 6
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be re
Autor:
Bernd Kaina, Markus Lӧbrich, Christian Ebel, Teodora Nikolova, Lucie Iloff, Michael Ensminger
Publikováno v:
The Journal of Cell Biology
DNA double-strand breaks and chromosomal aberrations after treatment with N-alkylating agents likely arise as a result of replication fork collision with single-strand breaks generated during base excision repair.
Exposures that methylate DNA po
Exposures that methylate DNA po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f6bb357b9813b161350b354ef3dceb
Autor:
Michael Ensminger, Markus Löbrich
Publikováno v:
The British Journal of Radiology
Double-strand breaks (DSBs) represent the most severe type of DNA damage since they can lead to genomic rearrangements, events that can initiate and promote tumorigenic processes. DSBs arise from various exogenous agents that induce two single-strand
Autor:
Sarita Bhetawal, Andrés Cruz-García, Marta Llorens-Agost, Richard D. Wood, Markus Löbrich, Anugrah Gawai, Wolf Dietrich Heyer, Michael Ensminger, Jie Liu, Hang Phuong Le
Publikováno v:
Nature Cell Biology. 24:124-124
Autor:
Kean S. Goh, Gail Cho, Sarah Mohammed, Michael Ensminger, Korena Goodell, Hsing-Ju Tsai, A. Van Scoy, Martice E Vasquez
Publikováno v:
Chemosphere. 184:1028-1035
Monitoring of surface waters for organic contaminants is costly. Grab water sampling often results in non-detects for organic contaminants due to missing a pulse event or analytical instrumentation limitations with a small sample size. Continuous Low
Publikováno v:
The Science of the total environment. 718
Pyrethroid insecticides are frequently detected in urban surface waters at levels that are deleterious to sensitive aquatic species. The California Department of Pesticide Regulation (CDPR) Surface Water Protection Program collected 717 water and 191