Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Michael Elgart"'
Autor:
Yana Hrytsenko, Benjamin Shea, Michael Elgart, Nuzulul Kurniansyah, Genevieve Lyons, Alanna C. Morrison, April P. Carson, Bernhard Haring, Braxton D. Mitchell, Bruce M. Psaty, Byron C. Jaeger, C. Charles Gu, Charles Kooperberg, Daniel Levy, Donald Lloyd-Jones, Eunhee Choi, Jennifer A. Brody, Jennifer A. Smith, Jerome I. Rotter, Matthew Moll, Myriam Fornage, Noah Simon, Peter Castaldi, Ramon Casanova, Ren-Hua Chung, Robert Kaplan, Ruth J. F. Loos, Sharon L. R. Kardia, Stephen S. Rich, Susan Redline, Tanika Kelly, Timothy O’Connor, Wei Zhao, Wonji Kim, Xiuqing Guo, Yii-Der Ida Chen, The Trans-Omics in Precision Medicine Consortium, Tamar Sofer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting of
Externí odkaz:
https://doaj.org/article/322241f378754ea881e603a18375361b
Autor:
Yi-Ting Tsai, Yana Hrytsenko, Michael Elgart, Usman A. Tahir, Zsu-Zsu Chen, James G. Wilson, Robert E. Gerszten, Tamar Sofer
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100304- (2024)
Summary: Genetic correlation refers to the correlation between genetic determinants of a pair of traits. When using individual-level data, it is typically estimated based on a bivariate model specification where the correlation between the two variab
Externí odkaz:
https://doaj.org/article/7493a82d16f842ec929d7929506e2863
Autor:
Michael Elgart, Ying Zhang, Yuan Zhang, Bing Yu, Youngmee Kim, Phyllis C. Zee, Marc D. Gellman, Eric Boerwinkle, Martha L. Daviglus, Jianwen Cai, Susan Redline, Robert D. Burk, Robert Kaplan, Tamar Sofer
Publikováno v:
EBioMedicine, Vol 98, Iss , Pp 104891- (2023)
Summary: Background: The human microbiome is linked to multiple metabolic disorders such as obesity and diabetes. Obstructive sleep apnoea (OSA) is a common sleep disorder with several metabolic risk factors. We investigated the associations between
Externí odkaz:
https://doaj.org/article/faf5162918064461a0223b13087acf03
Autor:
Michael Elgart, Genevieve Lyons, Santiago Romero-Brufau, Nuzulul Kurniansyah, Jennifer A. Brody, Xiuqing Guo, Henry J. Lin, Laura Raffield, Yan Gao, Han Chen, Paul de Vries, Donald M. Lloyd-Jones, Leslie A. Lange, Gina M. Peloso, Myriam Fornage, Jerome I. Rotter, Stephen S. Rich, Alanna C. Morrison, Bruce M. Psaty, Daniel Levy, Susan Redline, the NHLBI’s Trans-Omics in Precision Medicine (TOPMed) Consortium, Tamar Sofer
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Combining a standard polygenic risk score (PRS) as a feature in a machine learning model increases the percentage variance explained for those traits, helping to account for non-linearities or interaction effects in genetics-based prediction models.
Externí odkaz:
https://doaj.org/article/d5b943dc87ee467e87670ec528cf6ef7
Autor:
Yuan Zhang, Michael Elgart, Nuzulul Kurniansyah, Brian W. Spitzer, Heming Wang, Doyoon Kim, Neomi Shah, Martha Daviglus, Phyllis C. Zee, Jianwen Cai, Daniel J. Gottlieb, Brian E. Cade, Susan Redline, Tamar Sofer
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104288- (2022)
Summary: Background: Obstructive Sleep Apnoea (OSA) often co-occurs with cardiometabolic and pulmonary diseases. This study is to apply genetic analysis methods to explain the associations between OSA and related phenotypes. Methods: In the Hispanic
Externí odkaz:
https://doaj.org/article/db3750c2f34b40e7a3b797e23b393873
Autor:
Liron Friedman, Hadas Mamane, Kartik Chandran, Martin Jekel, Haim Cikurel, Uwe Hübner, Michael Elgart, Shlomi Dagan, Jorge Santo-Domingo, Dror Avisar
Publikováno v:
Clean Technologies, Vol 2, Iss 1, Pp 53-73 (2020)
Tertiary wastewater treatment could provide a reliable source of water for reuse. Amongst these types of wastewater treatment, deep-bed filtration of secondary effluents can effectively remove particles and organic matter; however, NH4+ and NO2− ar
Externí odkaz:
https://doaj.org/article/45255032ce17452793a84342032a39c4
Autor:
Garold Fuks, Michael Elgart, Amnon Amir, Amit Zeisel, Peter J. Turnbaugh, Yoav Soen, Noam Shental
Publikováno v:
Microbiome, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Background Most of our knowledge about the remarkable microbial diversity on Earth comes from sequencing the 16S rRNA gene. The use of next-generation sequencing methods has increased sample number and sequencing depth, but the read length o
Externí odkaz:
https://doaj.org/article/117398ca32824b1187e9f8b89d93e3ef
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The gut microbiota can play various roles in the host's physiology, but is not known to influence the germ line. Here, Elgart et al. show that certain extracellular gut bacteria can affect oogenesis and embryo development in the fruit fly.
Externí odkaz:
https://doaj.org/article/bce32456b8274c6fa9021a064b648bfc
Autor:
Chen Farhy, Michael Elgart, Zehavit Shapira, Varda Oron-Karni, Orly Yaron, Yotam Menuchin, Gideon Rechavi, Ruth Ashery-Padan
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76489 (2013)
The coupling between cell-cycle exit and onset of differentiation is a common feature throughout the developing nervous system, but the mechanisms that link these processes are mostly unknown. Although the transcription factor Pax6 has been implicate
Externí odkaz:
https://doaj.org/article/cdc013bf11ee4149819e01b67cf40bb5
Autor:
Yuan Zhang, Michael Elgart, Einat Granot-Hershkovitz, Heming Wang, Wassim Tarraf, Alberto R. Ramos, Ariana M. Stickel, Donglin Zeng, Tanya P. Garcia, Fernando D. Testai, Sylvia Wassertheil-Smoller, Carmen R. Isasi, Martha L. Daviglus, Robert Kaplan, Myriam Fornage, Charles DeCarli, Susan Redline, Hector M. González, Tamar Sofer
BackgroundSleep phenotypes have been reported to be associated with cognitive ageing outcomes. However, there is limited research using genetic variants as proxies for sleep traits to study their associations. We estimated associations between Polyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d713fc74c7c8403a4d759b4db4f693
https://escholarship.org/uc/item/55t40089
https://escholarship.org/uc/item/55t40089