Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael E.T.I. Boerrigter"'
Autor:
Michael E.T.I. Boerrigter
Publikováno v:
Environmental and Molecular Mutagenesis. 34:140-147
The evaluation of the relationship between the dose to DNA of a genotoxic carcinogen and in vivo somatic cell mutagenesis may provide important information on the mechanisms leading to induced mutational events. The induction of DNA adducts and DNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e991504cfe860c89b1abc90bda8e54
https://doi.org/10.1002/(sici)1098-2280(1999)34:2/3<140::aid-em13>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1999)34:2/3<140::aid-em13>3.0.co
Autor:
Michael E.T.I. Boerrigter
Publikováno v:
Environmental and Molecular Mutagenesis. 32:148-154
Transgenic mice carrying bacteriophage lambda-based vectors harboring a lacZ or lacI reporter gene have been used in recent years for the detection, quantification, and characterization of spontaneous and induced gene mutations in vivo. The usefulnes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41950e86ba32d9fd329d860b5de23a34
https://doi.org/10.1002/(sici)1098-2280(1998)32:2<148::aid-em10>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1998)32:2<148::aid-em10>3.0.co
Publikováno v:
Mechanisms of Ageing and Development. 99:257-271
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bb7385c0397eaf4f3c1a48f0e642323
https://doi.org/10.1016/s0047-6374(97)00155-3
https://doi.org/10.1016/s0047-6374(97)00155-3
Publikováno v:
Mutagenesis. 11:111-118
To study in vivo somatic mutations a C57BL/6 transgenic mouse model was constructed harboring multiple chromosomally integrated copies of the plasmid pUR288, which carried the lacZ reporter gene as the mutational target. We previously demonstrated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c5b9211fa778fe57ae577544e52010
https://doi.org/10.1093/mutage/11.1.111
https://doi.org/10.1093/mutage/11.1.111
Publikováno v:
Mutation Research/DNAging. 338:203-213
Theories on the causes of aging, based on the accumulation of somatic mutations in tissues of an organism, were formulated decades ago, but remain insufficiently tested. Transgenic animals, equipped with integrated bacterial reporter genes that can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eca08418d1bb88a63e1901854879398
https://doi.org/10.1016/0921-8734(95)00025-2
https://doi.org/10.1016/0921-8734(95)00025-2
Publikováno v:
Journal of Gerontology. 48:B11-B16
An attempt was made to assign mouse lifespan-associated interstrain differences in DNA repair to a specific chromosomal region using a set of congenic mice. The sensitive 32P-postlabeling assay was employed to measure the removal of benzo[a]pyrene-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6809dfd7c0564e3cebe11af484f62762
https://doi.org/10.1093/geronj/48.1.b11
https://doi.org/10.1093/geronj/48.1.b11
Autor:
Michael E.T.I. Boerrigter, Jan Vijg, Eduardo Arrigoni-Martelli, Jeanne Y. Wei, Claudio Franceschi
Publikováno v:
Carcinogenesis. 14:2131-2136
DNA single-strand breaks (SSBs) and their disappearance during repair incubation were determined by alkaline filter elution in freshly isolated human peripheral blood lymphocytes (PBLs) after in vitro treatment with either the oxygen radical-generati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d20dfef15ed7c8fe2b75deae0df5560
https://doi.org/10.1093/carcin/14.10.2131
https://doi.org/10.1093/carcin/14.10.2131
Publikováno v:
Experimental Cell Research. 192:61-66
The induction and disappearance of DNA single-strand breaks (SSB) in human peripheral blood lymphocytes (PBL) and fibroblasts exposed to methyl methanesulfonate (MMS) were investigated by using the alkaline filter elution assay. In the two cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7ee752c5e506f6b62494b3939007b6
https://doi.org/10.1016/0014-4827(91)90157-p
https://doi.org/10.1016/0014-4827(91)90157-p
Publikováno v:
Carcinogenesis. 12:77-82
We investigated the induction and disappearance of DNA lesions that are detected as single-strand breaks (SSBs) with the alkaline filter elution technique, in human peripheral blood lymphocytes (PBLs) following exposure to N-ethyl-N-nitrosourea (ENU)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23941b73f42e65a458e75eacd53885d5
https://doi.org/10.1093/carcin/12.1.77
https://doi.org/10.1093/carcin/12.1.77
Publikováno v:
Neurobiology of Aging. 11:169-173
It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d58952db7fe98136301c64a065a32b
https://doi.org/10.1016/0197-4580(90)90542-8
https://doi.org/10.1016/0197-4580(90)90542-8