Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael E.G. Sauria"'
Autor:
Yoon Hee Jung, Michael E.G. Sauria, Xiaowen Lyu, Manjinder S. Cheema, Juan Ausio, James Taylor, Victor G. Corces
Publikováno v:
Cell Reports, Vol 18, Iss 6, Pp 1366-1382 (2017)
The mammalian sperm genome is thought to lack substantial information for the regulation of future expression after fertilization. Here, we show that most promoters in mouse sperm are flanked by well-positioned nucleosomes marked by active histone mo
Externí odkaz:
https://doaj.org/article/f605b1eef400437babc5f8cd9f8420ae
Autor:
Guanjue Xiang, Xi He, Belinda M. Giardine, Kathryn J. Weaver, Dylan J. Taylor, Rajiv C. McCoy, Camden Jansen, Cheryl A. Keller, Alexander Q. Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F. Heuston, Stacie M. Anderson, Jing Luan, Marit W. Vermunt, Feng Yue, Michael E.G. Sauria, Michael C. Schatz, James Taylor, Berthold Göttgens, Jim R. Hughes, Douglas R. Higgs, Mitchell J. Weiss, Yong Cheng, Gerd A. Blobel, David Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross C. Hardison
Knowledge of locations and activities ofcis-regulatory elements (CREs) is needed to decipher basic mechanisms of gene regulation and to understand the impact of genetic variants on complex traits. Previous studies identified candidate CREs (cCREs) us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef37c806f6c18c3930749db34dc396f5
https://doi.org/10.1101/2023.04.02.535219
https://doi.org/10.1101/2023.04.02.535219
Autor:
Arang Rhie, Sergey Nurk, Monika Cechova, Savannah J. Hoyt, Dylan J. Taylor, Nicolas Altemose, Paul W. Hook, Sergey Koren, Mikko Rautiainen, Ivan A. Alexandrov, Jamie Allen, Mobin Asri, Andrey V. Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, Mark Diekhans, Paul Flicek, Giulio Formenti, Arkarachai Fungtammasan, Carlos Garcia Giron, Erik Garrison, Ariel Gershman, Jennifer Gerton, Patrick G.S. Grady, Andrea Guarracino, Leanne Haggerty, Reza Halabian, Nancy F. Hansen, Robert Harris, Gabrielle A. Hartley, William T. Harvey, Marina Haukness, Jakob Heinz, Thibaut Hourlier, Robert M. Hubley, Sarah E. Hunt, Stephen Hwang, Miten Jain, Rupesh K. Kesharwani, Alexandra P. Lewis, Heng Li, Glennis A. Logsdon, Julian K. Lucas, Wojciech Makalowski, Christopher Markovic, Fergal J. Martin, Ann M. Mc Cartney, Rajiv C. McCoy, Jennifer McDaniel, Brandy M. McNulty, Paul Medvedev, Alla Mikheenko, Katherine M. Munson, Terence D. Murphy, Hugh E. Olsen, Nathan D. Olson, Luis F. Paulin, David Porubsky, Tamara Potapova, Fedor Ryabov, Steven L. Salzberg, Michael E.G. Sauria, Fritz J. Sedlazeck, Kishwar Shafin, Valery A. Shepelev, Alaina Shumate, Jessica M. Storer, Likhitha Surapaneni, Angela M. Taravella Oill, Françoise Thibaud-Nissen, Winston Timp, Marta Tomaszkiewicz, Mitchell R. Vollger, Brian P. Walenz, Allison C. Watwood, Matthias H. Weissensteiner, Aaron M. Wenger, Melissa A. Wilson, Samantha Zarate, Yiming Zhu, Justin M. Zook, Evan E. Eichler, Rachel O’Neill, Michael C. Schatz, Karen H. Miga, Kateryna D. Makova, Adam M. Phillippy
The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure including long palindromes, tandem repeats, and segmental duplications. As a result, more than half of the Y chromosome is missing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38b477c2daccca72d1302cd2225927d
https://doi.org/10.1101/2022.12.01.518724
https://doi.org/10.1101/2022.12.01.518724
Autor:
Chen-Shan Chin, Stephanie M Yan, Skylar Martin, Jeffrey A. Rosenfeld, Alaina Shumate, Arang Rhie, Daniela C. Soto, Sergey Koren, Melanie Kirsche, Joyce V. Lee, Chunlin Xiao, Megan Y. Dennis, Dylan J. Taylor, Ryan M. Layer, Mitchell R. Vollger, Justin M. Zook, Adam M. Phillippy, Melissa M. Meredith, Karen H. Miga, Pavel Avdeyev, Nancy F. Hansen, Benedict Paten, Kishwar Shafin, Danny E. Miller, Jennifer McDaniel, Sergey Aganezov, Rajiv C. McCoy, Michael E.G. Sauria, Nathan D. Olson, Justin Wagner, Samantha Zarate, Fritz J. Sedlazeck, Michael C. Schatz
Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200 Mbp of sequence, corrects thousands of structural errors, and unlocks the most complex regions of the human genome to clinical and functional study. Here we demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350c95a5c44ac46cc00470e6f533b832
https://doi.org/10.1101/2021.07.12.452063
https://doi.org/10.1101/2021.07.12.452063
Autor:
Michael E.G. Sauria, Ariel Gershman, Mitchell R. Vollger, Hoyt Sj, Michael C. Schatz, Caldas Gv, Rachel J. O’Neill, Winston Timp, Karen H. Miga, Glennis A. Logsdon, Sergey Koren, Roham Razaghi, Evan E. Eichler, Nicolas Altemose, Paul W. Hook, Arang Rhie, Adam M. Phillippy
The completion of the first telomere-to-telomere human genome, T2T-CHM13, enables exploration of the full epigenome, removing limitations previously imposed by the missing reference sequence. Existing epigenetic studies omit unassembled and unmappabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52afdeac4b592883f41ab5293c7822b1
https://doi.org/10.1101/2021.05.26.443420
https://doi.org/10.1101/2021.05.26.443420
Autor:
Douglas R. Higgs, Belinda Giardine, Cheryl A. Keller, Mitchell J. Weiss, Elisabeth F. Heuston, Berthold Göttgens, Guanjue Xiang, Gerd A. Blobel, Amber Miller, Michael E.G. Sauria, James Taylor, Alexander Q. Wixom, Feng Yue, Yu Zhang, Jens Lichtenberg, Qiang Li, Kathryn Weaver, April Cockburn, Yong Cheng, Ross C. Hardison, David M. Bodine, Shaun Mahony, Lin An, Jim R. Hughes
Thousands of epigenomic data sets have been generated in the past decade, but it is difficult for researchers to effectively use all the data relevant to their projects. Systematic integrative analysis can help meet this need, and the VISION project
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b41c0a10dfcacf607ca6bf407116681
Autor:
Xiaowen Lyu, Manjinder S. Cheema, James Taylor, Michael E.G. Sauria, Juan Ausió, Yoon Hee Jung, Victor G. Corces
Publikováno v:
Cell Reports, Vol 18, Iss 6, Pp 1366-1382 (2017)
The mammalian sperm genome is thought to lack substantial information for the regulation of future expression after fertilization. Here, we show that most promoters in mouse sperm are flanked by well-positioned nucleosomes marked by active histone mo
Autor:
Arya Kaul, Job Dekker, Anshul Kundaje, Hakan Ozadam, Mark Gerstein, James Taylor, Michael E.G. Sauria, Feng Yue, Ye Zhan, Ferhat Ay, Tao Yang, Abhijit Chakraborty, Galip Gürkan Yardımcı, Oana Ursu, Fan Song, Koon-Kiu Yan, Bryan R. Lajoie, William Stafford Noble, Qiang Li
Publikováno v:
Genome Biology
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Background Hi-C is currently the most widely used assay to investigate the 3D organization of the genome and to study its role in gene regulation, DNA replication, and disease. However, Hi-C experiments are costly to perform and involve multiple comp
Autor:
Michael E.G. Sauria, M. C. Gaillard, Katja Pekrun, Xianrong Wong, Robert A. Ach, E. DeBoy, James Taylor, N. A. Yamada, Peter Tsang, Victoria E. Hoskins, Karen L. Reddy, Teresa Romeo Luperchio
Three-dimensional (3D) genome organization is thought to be important for regulation of gene expression. Chromosome conformation capture-based studies have uncovered ensemble organizational principles such as active (A) and inactive (B) compartmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2afe9df4e076c73243b4b26d906e0c
Autor:
Michael E.G. Sauria, Raghav Goyal, Robert J. Johnston, Kayla Viets, James Taylor, Chaim Chernoff, Sang Tran, Caitlin Anderson, Eileen E. M. Furlong, Rebecca Rodríguez Viales, Lukas Voortman, Max Echterling, Andrew Gordus, Abigail Dove
Publikováno v:
Dev Cell
Summary Homologous chromosomes colocalize to regulate gene expression in processes including genomic imprinting, X-inactivation, and transvection. In Drosophila, homologous chromosomes pair throughout development, promoting transvection. The “butto