Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Michael E. Selsted"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 87 (2024)
Rheumatoid arthritis is a systemic autoimmune inflammatory disease that affects millions of people worldwide. There are multiple disease-modifying anti-rheumatic drugs available; however, many patients do not respond to any treatment. A disintegrin a
Externí odkaz:
https://doaj.org/article/2f3450fb3df0473eb0e9be6699abfeed
Publikováno v:
Mediators of Inflammation, Vol 2023 (2023)
Theta- (θ-) defensins are pleiotropic host defense peptides with antimicrobial- and immune-modulating activities. Immune stimulation of cells with lipopolysaccharide (LPS, endotoxin) activates proinflammatory gene expression and cytokine secretion,
Externí odkaz:
https://doaj.org/article/72610aae30b3400fa69f61fcc6a9439e
Autor:
Justin B. Schaal, Yoshihiro Eriguchi, Dat Q. Tran, Patti A. Tran, Chase Hawes, Anthony E. Cabebe, Kaitlyn Pike, Katie Trinh, André J. Ouellette, Michael E. Selsted
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The emergence of infections by carbapenem resistant Enterobacteriaceae (CRE) pathogens has created an urgent public health threat, as carbapenems are among the drugs of last resort for infections caused by a growing fraction of multi-drug re
Externí odkaz:
https://doaj.org/article/f2dbf162bf184f31849a458d2986837d
Autor:
Mansour A. Dughbaj, Jordanna G. Jayne, A Young J. Park, Timothy J. Bensman, Marquerita Algorri, Andre J. Ouellette, Michael E. Selsted, Paul M. Beringer
Publikováno v:
Antibiotics, Vol 10, Iss 9, p 1043 (2021)
Vicious cycles of chronic airway obstruction, lung infections with Pseudomonas aeruginosa, and neutrophil-dominated inflammation contribute to morbidity and mortality in cystic fibrosis (CF) patients. Rhesus theta defensin-1 (RTD-1) is an antimicrobi
Externí odkaz:
https://doaj.org/article/f41e8ed08e9e4187b2214ab78cd6cc90
Publikováno v:
Journal of Fungi, Vol 6, Iss 4, p 241 (2020)
Current treatment for invasive fungal diseases is limited to three classes of antifungal drugs: azoles, polyenes, and echinocandins. The most recently introduced antifungal class, the echinocandins, was first approved nearly 30 years ago. The limited
Externí odkaz:
https://doaj.org/article/92ce53619b094649847d8d576ba05e7a
Autor:
Justin B Schaal, Dat Q Tran, Akshay Subramanian, Reshma Patel, Teresina Laragione, Kevin D Roberts, Katie Trinh, Prasad Tongaonkar, Patti A Tran, Dmitriy Minond, Gregg B Fields, Paul Beringer, André J Ouellette, Percio S Gulko, Michael E Selsted
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187868 (2017)
θ-defensins constitute a family of macrocyclic peptides expressed exclusively in Old World monkeys. The peptides are pleiotropic effectors of innate immunity, possessing broad spectrum antimicrobial activities and immunoregulatory properties. Here w
Externí odkaz:
https://doaj.org/article/aee9ec4945eb4998b34e01489908b108
Autor:
Miriam Wilmes, Marina Stockem, Gabriele Bierbaum, Martin Schlag, Friedrich Götz, Dat Q. Tran, Justin B. Schaal, André J. Ouellette, Michael E. Selsted, Hans-Georg Sahl
Publikováno v:
Antibiotics, Vol 3, Iss 4, Pp 617-631 (2014)
θ-Defensins are cyclic antimicrobial peptides expressed in leukocytes of Old world monkeys. To get insight into their antibacterial mode of action, we studied the activity of RTDs (rhesus macaque θ-defensins) against staphylococci. We found that in
Externí odkaz:
https://doaj.org/article/7b14842637b245e8880e496eb528f04b
Publikováno v:
Antibiotics, Vol 3, Iss 4, Pp 493-508 (2014)
Small intestinal Paneth cells secrete a-defensin peptides, termed cryptdins (Crps) in mice, into the intestinal lumen, where they confer immunity to oral infections and define the composition of the ileal microbiota. In these studies, facultative bac
Externí odkaz:
https://doaj.org/article/1d77f86cbc024e9f87dead667f7ef423
Autor:
A. Young J. Park, Dat Q. Tran, Justin B. Schaal, Mengxi Wang, Michael E. Selsted, Paul M. Beringer
Publikováno v:
Antimicrobial agents and chemotherapy. 66(3)
Severe illness caused by coronavirus disease 2019 (COVID-19) is characterized by an overexuberant inflammatory response resulting in acute respiratory distress syndrome (ARDS) and progressive respiratory failure (A. Gupta, M. V. Madhavan, K. Sehgal,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf7de3d505d0969d2c1d6a3dff8e363
https://pubmed.ncbi.nlm.nih.gov/35041507
https://pubmed.ncbi.nlm.nih.gov/35041507
Autor:
Patti Tran, A. young Park, Michael E. Selsted, Anthony E. Cabebe, Justin B. Schaal, Dat Q. Tran, Virginia Basso, Diana Ngole, Andre J. Ouellette, Paul M. Beringer, Yoshihiro Eriguchi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Invasive candidiasis is an increasingly frequent cause of serious and often fatal infections in hospitalized and immunosuppressed patients. Mortality rates associated with these infections have risen sharply due to the emergence of multidrug resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fd9dccc73e0117fd82314146f8cf89
http://link.springer.com/article/10.1038/s41598-019-53402-z
http://link.springer.com/article/10.1038/s41598-019-53402-z