Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michael E. Pape"'
Autor:
Clay T. Cramer, Brian Goetz, Krista L.M. Hopson, Gregory J. Fici, Rose M. Ackermann, Stephen C. Brown, Charles L. Bisgaier, W.G. Rajeswaran, Daniela C. Oniciu, Michael E. Pape
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1289-1301 (2004)
We have identified a novel ω-hydroxy-alkanedicarboxylic acid, ESP 55016, that favorably alters serum lipid variables in obese female Zucker (fa/fa) rats. ESP 55016 reduced serum non-HDL-cholesterol (non-HDL-C), triglyceride, and nonesterified fatty
Externí odkaz:
https://doaj.org/article/6e66dc604caa440cad0b2da77bb5ad67
Autor:
Charles L. Bisgaier, Arnold D. Essenburg, Blake C. Barnett, Bruce J. Auerbach, Sabine Haubenwallner, Todd Leff, Andrew D. White, Paul Creger, Michael E. Pape, Thomas J. Rea, Roger S. Newton
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 1, Pp 17-30 (1998)
In the current studies we describe the effects of PD 72953 and related compounds on lipoprotein levels in chowfed male rats. After 2 weeks, 10 mg/kg of PD 72953 daily was as effective as 100 mg/kg gemfibrozil for elevating HDL-cholesterol. At 100 mg/
Externí odkaz:
https://doaj.org/article/c311ea301bc5471db5bad401d9635744
Publikováno v:
Mediators of Inflammation, Vol 2, Iss 4, Pp 271-277 (1993)
Tumour necrosis factor (TNF) inhibits the accumulation of acetyl CoA carboxylase (ACC) mRNA by decreasing the rate of ACC gene transcription. The ACC mRNA species found in 30A5 cells are generated from promoter II and TNF inhibits the accumulation of
Externí odkaz:
https://doaj.org/article/70d4dd0aea514ab8a6f2170db8e5b3c5
Autor:
Lianhao Zhang, Ralf Mueller, Michael E. Pape, Andrew McKee, Eelco J. Ebbers, Charles L. Bisgaier, Bruce H. McCosar, Jean-Louis H Dasseux, Clay T. Cramer, Dennis Smith, Mike Relou, Henk Regeling, Emil Pop, B.R. Krause, Frank M. C. Leemhuis, Roel P.L. Bell, Dennis Verdijk, Brian Goetz, Daniela Carmen Oniciu
Publikováno v:
Synthetic Communications. 36:365-391
A series of pantolactone and pantothenic acid derivatives (1–10) were synthesized to be tested for their potential as lipid regulating agents that act as Coenzyme‐A mimics. The syntheses were performed with moderate to high yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53ca7faef49ee107a23924ef932d1f1
https://doi.org/10.1080/00397910500377545
https://doi.org/10.1080/00397910500377545
Autor:
Roel P L, Bell, Dennis, Verdijk, Mike, Relou, Dennis, Smith, Henk, Regeling, Eelco J, Ebbers, Frank M C, Leemhuis, Daniela C, Oniciu, Clay T, Cramer, Brian, Goetz, Michael E, Pape, Brian R, Krause, Charles L, Bisgaier, Jean-Louis, Dasseux
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:223-236
A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78510470ed7f346fd296d9349082a003
https://doi.org/10.1016/j.bmc.2004.09.046
https://doi.org/10.1016/j.bmc.2004.09.046
Autor:
Daniela C. Oniciu, Sergey Denisenko, Ralf Mueller, Charles L Bisgaier, Krista L Hopson, Bruce H McCosar, Tian-Bao Huang, Lian Hao Zhang, Brian Goetz, Caiming Duan, Jing Yang, Clay T Cramer, Catherine Delaney Freiman, Jean-Louis H Dasseux, Otto J Geoffroy, Michael E Pape, Emil Pop
Publikováno v:
Journal of Medicinal Chemistry. 47:6082-6099
Keto-substituted hydrocarbons with 11-19 methylene and bis-terminal hydroxyl and carboxyl groups have been synthesized and evaluated in both in vivo and in vitro assays for their potential to favorably alter lipid disorders including metabolic syndro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf38e2e894c4d1e64dbb8931721f353b
https://doi.org/10.1021/jm040006p
https://doi.org/10.1021/jm040006p
Autor:
Anna Denisenko, Ralf Mueller, Catherine Delaney Freiman, Emil Pop, Krista L Hopson, Charles L Bisgaier, Tian-Bao Huang, Daniela C. Oniciu, Lian Hao Zhang, Brian Goetz, Jing Yang, Olga V Denisko, Jean-Louis H Dasseux, Michael E Pape, Caiming Duan, Clay T Cramer
Publikováno v:
Journal of Medicinal Chemistry. 47:5183-5197
Long hydrocarbon chain ethers with bis-terminal hydroxyl or carboxyl groups have been synthesized and evaluated for their potential to favorably alter lipid disorders including metabolic syndrome. Compounds were assessed for their effects on the de n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723dc78b80e13fdbb6744d41e0debf10
https://doi.org/10.1021/jm0400395
https://doi.org/10.1021/jm0400395
Autor:
Rose Ackermann, Gregory J. Fici, Brian Goetz, Krista L.M. Hopson, Michael E. Pape, Daniela C. Oniciu, Stephen C. Brown, Clay T. Cramer, W.G. Rajeswaran, Charles L. Bisgaier
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1289-1301 (2004)
We have identified a novel omega-hydroxy-alkanedicarboxylic acid, ESP 55016, that favorably alters serum lipid variables in obese female Zucker (fa/fa) rats. ESP 55016 reduced serum non-HDL-cholesterol (non-HDL-C), triglyceride, and nonesterified fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf00998644f35056543cf27844790a5b
http://www.sciencedirect.com/science/article/pii/S0022227520317855
http://www.sciencedirect.com/science/article/pii/S0022227520317855
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 33:1215-1226
To induce atherogenesis in mice, a high fat (HF) diet is supplemented with cholic acid (CA), which increases apoB-containing particles and lower apoA-I-containing particles. HF diet without CA increases levels of both HDL and LDL, suggesting that CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b46f1262cf6cda74190a7876248ba1
https://doi.org/10.1016/s1357-2725(01)00080-2
https://doi.org/10.1016/s1357-2725(01)00080-2
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2, Iss 4, Pp 271-277 (1993)
Mediators of Inflammation, Vol 2, Iss 4, Pp 271-277 (1993)
Tumour necrosis factor (TNF) inhibits the accumulation of acetyl CoA carboxylase (ACC) mRNA by decreasing the rate of ACC gene transcription. The ACC mRNA species found in 30A5 cells are generated from promoter II and TNF inhibits the accumulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d031356ba0ef70e4fcb6fae9e56b2b3f
https://doi.org/10.1155/s0962935193000377
https://doi.org/10.1155/s0962935193000377