Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael E. O'Brien"'
Autor:
Michael E. O’Brien, Michael Chary, Philicia Moonsamy, Michele M. Burns, Andrew Tom, Gaston Cudemus
Publikováno v:
Toxicology Communications, Vol 5, Iss 1, Pp 85-87 (2021)
AbstractIntroduction Bupropion overdose can produce seizures, arrhythmias, and shock. The toxicokinetics of massive bupropion ingestions are not well characterized.Case report A 22-year-old female ingested an estimated 40.5 g (644 mg/kg) of extended
Externí odkaz:
https://doaj.org/article/788ad2a9ae4f4cc99db09640eb5a7131
Autor:
Michael E. O’Brien, Divay Chandra, Robert C. Wilson, Chad M. Karoleski, Carl R. Fuhrman, Joseph K. Leader, Jiantao Pu, Yingze Zhang, Alison Morris, Seyed Nouraie, Jessica Bon, Zsolt Urban, Frank C. Sciurba
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Elastin breakdown and the resultant loss of lung elastic recoil is a hallmark of pulmonary emphysema in susceptible individuals as a consequence of tobacco smoke exposure. Systemic alterations to the synthesis and degradation of e
Externí odkaz:
https://doaj.org/article/89107b51afc44518ab13e570f060b88e
Autor:
Michael E. O’Brien, Grace Murray, Debananda Gogoi, Azeez Yusuf, Cormac McCarthy, Mark R. Wormald, Michelle Casey, Claudie Gabillard-Lefort, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2441 (2022)
Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived proteases and can modulate innate immune mechanisms through its anti-inflammatory activities mediated by a broad spectrum of protein, cytokine, and cell surfac
Externí odkaz:
https://doaj.org/article/e95866bc15ba4f818cf757bd848d6ef5
Autor:
Tomeka L. Suber, Ina Nikolli, Michael E. O’Brien, James Londino, Jing Zhao, Kong Chen, Rama K. Mallampalli, Yutong Zhao
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background The ubiquitin-proteasome pathway, mediated in part, by ubiquitin E3 ligases, is critical in regulating cellular processes such as cell proliferation, apoptosis, and migration. FBXO17 was recently identified as an F-box protein tha
Externí odkaz:
https://doaj.org/article/ce1eec6c2d2044948a8cfbcc4e4f3671
Autor:
Laura T. Fee, Debananda Gogoi, Michael E. O’Brien, Emer McHugh, Michelle Casey, Ciara Gough, Mark Murphy, Ann M. Hopkins, Tomás P. Carroll, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1925 (2021)
Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by increased risk for emphysema, chronic obstructive pulmonary disease (COPD), vasculitis, and wound-healing impairment. Neutrophils play a central role in the pathogenesis of AATD. Dysregu
Externí odkaz:
https://doaj.org/article/fd3974a57e8e4a62945b8c22bb67bc45
Publikováno v:
Emergency Medicine Clinics of North America. 40:771-792
Pharmacologic therapy is an integral component in the management of most cardiovascular emergencies. This article reviews the pharmacotherapy involved in the treatment of acute coronary syndromes, acute heart failure, and various arrhythmias. The foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca55b632d7f59ca1fae604219c4cc14
https://doi.org/10.1016/j.emc.2022.06.012
https://doi.org/10.1016/j.emc.2022.06.012
Publikováno v:
Journal of Pharmacy Practice and Research. 51:211-215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df540bb4910435409b9e68098deb8b1b
https://doi.org/10.1002/jppr.1732
https://doi.org/10.1002/jppr.1732
Publikováno v:
The American Journal of Emergency Medicine. 44:312-314
Acute aortic dissection is a serious and life-threatening condition that requires prompt, effective management. The purpose of this study was to evaluate the efficacy and safety of esmolol for heart rate control in patients with acute aortic dissecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d62772e1983251ad82ac9d5dfc09860
https://doi.org/10.1016/j.ajem.2020.04.018
https://doi.org/10.1016/j.ajem.2020.04.018
Autor:
Daniel J. Ryan, Sinead Toomey, Robert Smyth, Stephen F. Madden, Julie Workman, Robert Cummins, Katherine Sheehan, Joanna Fay, Jarushka Naidoo, Oscar S. Breathnach, Patrick G. Morris, Liam Grogan, Michael E. O'Brien, Imran Sulaiman, Bryan T. Hennessy, Ross K. Morgan
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 168
Small diagnostic tissue samples can be inadequate in testing an expanding list of validated oncogenic driver alterations and fail to reflect intratumour heterogeneity (ITGH) in lung cancer. Liquid biopsies are non-invasive and may better reflect ITGH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bdde11032536306c359ccaa620d6de
https://pubmed.ncbi.nlm.nih.gov/35526313
https://pubmed.ncbi.nlm.nih.gov/35526313
Autor:
Michele M. Burns, Philicia Moonsamy, Gaston Cudemus, Michael E. O’Brien, Andrew Tom, Michael Chary
Publikováno v:
Toxicology Communications. 5:85-87
Bupropion overdose can produce seizures, arrhythmias, and shock. The toxicokinetics of massive bupropion ingestions are not well characterized.A 22-year-old female ingested an estimated 40.5 g (644...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b56c6b2aeb1031f446818e135976b5
https://doi.org/10.1080/24734306.2021.1903725
https://doi.org/10.1080/24734306.2021.1903725