Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Michael E. Mendelsohn"'
Autor:
Hideyuki Sasaki, Robert M. Blanton, Kazutaka Ueda, Richard H. Karas, Dong Ik Lee, Nazareno Paolocci, Brian O'Rourke, Michael E. Mendelsohn, Masaki Hashimoto, David A. Kass, Guangshuo Zhu, Yuan Yuan, Masayuki Sasaki, Eiki Takimoto, Djahida Bedja, Taro Kariya, Manling Zhang, Matthew Gabrielson, Nina Kaludercic
Publikováno v:
FEBS Lett
Phosphodiesterase 5 inhibition (PDE5i) activates cGMP-dependent protein kinase (PKG) and ameliorates heart failure; however, its impact on cardiac mitochondrial regulation has not been fully determined. Here, we investigated the role of the mitochond
Autor:
Robert M. Blanton, Kelly Tam, Gregory L. Martin, Michael E. Mendelsohn, Daniel M. Bloomfield, Richard H. Karas, Daniel A. Richards, Peiwen Liu, Suchita Pande, Mark Aronovitz
Publikováno v:
Circ Heart Fail
Background: Augmentation of NP (natriuretic peptide) receptor and cyclic guanosine monophosphate (cGMP) signaling has emerged as a therapeutic strategy in heart failure (HF). cGMP-specific PDE9 (phosphodiesterase 9) inhibition increases cGMP signalin
Autor:
Genri Numata, Richard H. Karas, Issei Komuro, Michael E. Mendelsohn, Taro Kariya, Eiki Takimoto, Kazutaka Ueda, Robert M. Blanton
Publikováno v:
Circulation Research. 125
Introduction: Regulator of G protein signaling 2 (RGS2) is a negative regulator of G protein-coupled signaling, and is potentiated by cGMP-PKG. Our prior work using a global deletion model demonstrated the protective role for RGS2 against mal-adaptiv
Autor:
Eric C Wooten, Lakshmanan K Iyer, Maria Claudia Montefusco, Alyson Kelley Hedgepeth, Douglas D Payne, Navin K Kapur, David E Housman, Michael E Mendelsohn, Gordon S Huggins
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8830 (2010)
Bicuspid Aortic Valve (BAV) is a highly heritable congenital heart defect. The low frequency of BAV (1% of general population) limits our ability to perform genome-wide association studies. We present the application of four a priori SNP selection te
Externí odkaz:
https://doaj.org/article/02d4282cd975434a860afd058be9a45d
Autor:
Alexandra Aicher, Christopher Heeschen, Susanne Feil, Franz Hofmann, Michael E Mendelsohn, Robert Feil, Stefanie Dimmeler
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4879 (2009)
BACKGROUND: Endothelium-derived nitric oxide plays an important role for the bone marrow microenvironment. Since several important effects of nitric oxide are mediated by cGMP-dependent pathways, we investigated the role of the cGMP downstream effect
Externí odkaz:
https://doaj.org/article/d7112d0dbd354324b2c8600e2a84805c
Autor:
David A. Kass, Kinya Seo, Dong I. Lee, Manling Zhang, Michael E. Mendelsohn, Richard H. Karas, Hideyuki Sasaki, Eiki Takimoto, Masafumi Kitakaze, Osamu Tsukamoto, Takahiro Nagayama, Seiji Takashima, Djahida Bedja, Steven Hsu, Guangshuo Zhu, Robert M. Blanton
Publikováno v:
Journal of Clinical Investigation. 124:2464-2471
Inhibition of cGMP-specific phosphodiesterase 5 (PDE5) ameliorates pathological cardiac remodeling and has been gaining attention as a potential therapy for heart failure. Despite promising results in males, the efficacy of the PDE5 inhibitor sildena
Autor:
Mark Aronovitz, Richard H. Karas, David A. Kass, Robert M. Blanton, Eiki Takimoto, Robrecht Thoonen, Michael E. Mendelsohn
Publikováno v:
The Journals of Gerontology: Series A. 68:1351-1355
Hypertensive heart disease causes significant mortality in older patients, yet there is an incomplete understanding of molecular mechanisms that regulate age-dependent hypertensive left ventricular hypertrophy (LVH). Therefore, we tested the hypothes
Autor:
Pierre Chambon, Paulo W. Pires, Mark Aronovitz, Anne M. Dorrance, Michelle J Zhao, Daniel Metzger, Amy McCurley, Michael A. Hill, Shawn B. Bender, Michael E Mendelsohn, Iris Z. Jaffe
Publikováno v:
Nature Medicine. 18:1429-1433
Hypertension is a cardiovascular risk factor present in over two-thirds of people over age 60 in North America; elevated blood pressure correlates with increased risk of heart attack, stroke and progression to heart and kidney failure. Current therap
Autor:
Adam P. McGraw, Afshin Ehsan, Lakshmanan K. Iyer, Michael E Mendelsohn, Iris Z. Jaffe, Giuseppe M.C. Rosano, Najwa N. Mohammad, Brenna G. Newfell, Paul L. Huang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1871-1880
Objective— Aldosterone (Aldo) antagonism prevents cardiovascular mortality by unclear mechanisms. Aldo binds to the mineralocorticoid receptor (MR), a ligand-activated transcription factor, which is expressed in human vascular cells. Here we define
Autor:
Jonas B. Galper, Michael E. Mendelsohn, Mie Higashimori, Jeffrey B. Tatro, Debbie Beasley, Kathryn J. Moore
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:50-57
Objective— Atherosclerosis encompasses a conspicuously maladaptive inflammatory response that might involve innate immunity. Here, we compared the role of Toll-like receptor 4 (TLR4) with that of TLR2 in intimal foam cell accumulation and inflammat