Výsledky vyhledávání - "Michael E. Lloyd"

Global phosphoproteomic study of high/low specific productivity industrially relevant mAb producing recombinant CHO cell lines

Autor: Matthew D. Osborne, Ronan M. Kelly, Martin Clynes, Christopher C. Frye, Michael Henry, Michael E. Lloyd, Laura Bryan, Paula Meleady

Publikováno v: Current Research in Biotechnology, Vol 3, Iss, Pp 49-56 (2021)

Understanding the biology of CHO cells at a cellular level is extremely valuable to the pharmaceutical industry, as it presents the opportunity to rationally engineer clonally derived cell lines (CDCLs) with elevated recombinant specific productivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c79b82f1d7683b96a0f04fa4574d724
http://www.sciencedirect.com/science/article/pii/S259026282100006X

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CRISPR/Cas12a-mediated CHO genome engineering can be effectively integrated at multiple stages of the cell line generation process for bioproduction

Autor: Ning Wang, Christopher C. Frye, Zhuo Cheng, Stephanie L. Sandefur, Michael E. Lloyd, Stephen F. Konieczny, Patrick G. Schweickert

Publikováno v: Biotechnology journalREFERENCES. 16(4)

Most biopharmaceuticals produced today are generated using Chinese hamster ovary (CHO) cells, therefore significant attention is focused on methods to improve CHO cell productivity and product quality. The discovery of gene-editing tools, such as CRI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd81b98fa053c8e4bb2501d8ed6415f9
https://pubmed.ncbi.nlm.nih.gov/33369118

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Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae

Autor: Michael E. Lloyd, Bryce W. Buchanan, Eric M. Rubenstein, Sarah M. Engle

Publikováno v: Journal of Visualized Experiments.

Regulation of protein abundance is crucial to virtually every cellular process. Protein abundance reflects the integration of the rates of protein synthesis and protein degradation. Many assays reporting on protein abundance (e.g., single-time point

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3d8ea52a1b45d5b95d1ad0546b9954
https://doi.org/10.3791/53975-v

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An analysis of inner-city students' attitudes towards violence before and after participation in the 'Cradle to Grave' programme

Autor: Mark J. Seamon, Amy J. Goldberg, Michael E. Lloyd, John P. Gaughan, Heather Kulp, Scott Charles, Julia M. Toto

Publikováno v: Injury. 41(1)

Cradle to Grave (C2G), a hospital-based violence prevention programme, brings inner-city youth into an urban Level I trauma centre to follow the path of an adolescent gunshot victim from trauma bay to morgue. We hypothesised that C2G alters student a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1719970d09a19509f864b8e9fd561d28
https://pubmed.ncbi.nlm.nih.gov/19828148

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