Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michael E. Lassman"'
Autor:
John S. Millar, Michael E. Lassman, Tiffany Thomas, Rajasekhar Ramakrishnan, Patricia Jumes, Richard L. Dunbar, Emil M. deGoma, Amanda L. Baer, Wahida Karmally, Daniel S. Donovan, Hashmi Rafeek, John A. Wagner, Stephen Holleran, Joseph Obunike, Yang Liu, Soumia Aoujil, Taylor Standiford, David E. Gutstein, Henry N. Ginsberg, Daniel J. Rader, Gissette Reyes-Soffer
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1214-1220 (2017)
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study descr
Externí odkaz:
https://doaj.org/article/519f42374d614106b1158dd25fc71604
Autor:
Yi Pan, Haihong Zhou, Ablatt Mahsut, Rory J. Rohm, Olga Berejnaia, Olga Price, Ying Chen, Jose Castro-Perez, Michael E. Lassman, David McLaren, James Conway, Kristian K. Jensen, Tiffany Thomas, Gissette Reyes-Soffer, Henry N. Ginsberg, David E. Gutstein, Michele Cleary, Stephen F. Previs, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1179-1187 (2014)
LC/MS quantification of multiple plasma proteins that differ by several orders of magnitude in concentration from a single sample is challenging. We present a strategy that allows the simultaneous determination of the concentration and turnover kinet
Externí odkaz:
https://doaj.org/article/ef4913b5d9e24bb88d6caef140d0f1f6
Autor:
Haihong Zhou, Wenyu Li, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, James Hubert, Kithsiri Herath, Theresa McLaughlin, Rory J. Rohm, Michael E. Lassman, Kenny K. Wong, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1223-1231 (2012)
Stable isotope tracer studies of apoprotein flux in rodent models present difficulties as they require working with small volumes of plasma. We demonstrate the ability to measure apoprotein flux by administering either 2H- or 18O-labeled water to mic
Externí odkaz:
https://doaj.org/article/6c63ed70b4314113b68773d0b93c3352
Publikováno v:
The Scientific World Journal, Vol 5, Pp 446-451 (2005)
A homogeneous assay was used to detect 2,4,6-trinitrotoluene (TNT) spiked into environmental water samples. This assay is based on changes in fluorescence emission intensity when TNT competitively displaces a fluorescently labeled, TNT analog bound t
Externí odkaz:
https://doaj.org/article/207b5195831146a590ba1ab465ce045b
Autor:
Omar F Laterza, Thomas McAvoy, Kapil Mayawala, Claire Li, Michael E. Lassman, Derek L Chappell, Scott K. Pruitt, Amy Cheng, Dinesh P. de Alwis, Aubrey Stoch
Publikováno v:
Clinical Pharmacology & Therapeutics. 109:1575-1582
Development of monoclonal antibodies (mAbs) targeting immune-checkpoint receptors (IMRs) for the treatment of cancer is one of the most active areas of investment in the biopharmaceutical industry. A key decision in the clinical development of anti-I
Autor:
Michael E. Lassman, Elizabeth J. Parks, Stephen F. Previs, Magdalene Szuszkiewicz-Garcia, Maria A. Ramos-Roman, David G. McLaren, Jennifer E. Vena, Sudha S. Shankar, Justine M. Mucinski
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 320(4)
A novel method to test human intestinal lipid handling using stable isotope labeling is presented and, for the first time, plasma appearance and lipid turnover were quantified in 12 healthy men following meals with varying amounts of fat. The method
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Quantifying pharmacodynamic biomarker changes enables decision making and clinical trials in drug development. Pharmacodynamic biomarkers are used to determine the effects of treatment on disease. Mass spectrometry offers a quantitative, s
Autor:
Donald J. Tweedie, Raymond Evers, Zufei Zhang, Erina Paul, Andrew H. Latham, Anne Gillespie, Kate Mostoller, Xiaoyan Chu, Ted Marenco, Aparna Chhibber, Matthew Murphy, Jianzhong Wen, Kenneth C. Lasseter, Nadia Cardillo Marricco, Patrick Larson, Daniel Tatosian, Michael E. Lassman, Jianmei Pang, Tami Crumley, Santosh C. Sutradhar, Ya-Juan Wang, S. Aubrey Stoch, Thomas Marbury, Ka Lai Yee
Publikováno v:
Clinical pharmacology and therapeutics. 109(2)
Renal impairment (RI) is known to influence the pharmacokinetics of nonrenally eliminated drugs, although the mechanism and clinical impact is poorly understood. We assessed the impact of RI and single dose oral rifampin (RIF) on the pharmacokinetics
Autor:
Michael E. Lassman, Wahida Karmally, John A. Wagner, Patricia Jumes, Amanda Baer, Gissette Reyes-Soffer, John S. Millar, Soumia Aoujil, David E. Gutstein, Yang Liu, Emile M. deGoma, Richard L. Dunbar, Daniel J. Rader, Stephen Holleran, Hashmi Rafeek, Tiffany Thomas, Rajasekhar Ramakrishnan, Daniel S. Donovan, Henry N. Ginsberg, Taylor Standiford, Joseph C. Obunike
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1214-1220 (2017)
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study descr
Publikováno v:
Rapid Communications in Mass Spectrometry. 31:193-199
Rationale In quantitative analysis of protein biomarkers and therapeutic proteins by liquid chromatography/mass spectrometry (LC/MS), it is a preferred and well-established approach to digest with proteolytic enzymes to produce smaller peptide fragme