Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Michael E. Kelly"'
Autor:
Hugo C. Temperley, Timothy Fannon, Niall J. O’Sullivan, Maeve O’Neill, Benjamin M. Mac Curtain, Charles Gilham, Jacintha O’Sullivan, Grainne O’Kane, Brian J. Mehigan, Sharon O’Toole, John O. Larkin, David Gallagher, Paul McCormick, Michael E. Kelly
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4005 (2024)
This systematic review investigates the potential of circulating tumour DNA (ctDNA) as a predictive biomarker in the management and prognosis of squamous cell carcinoma of the anal canal (SCCA). PubMed, EMBASE, and Cochrane Central Registry of Contro
Externí odkaz:
https://doaj.org/article/33f2bdf17f874abcb7b231b92804ee81
Autor:
Niall J. O’Sullivan, Michael E. Kelly
Publikováno v:
Current Oncology, Vol 30, Iss 5, Pp 4936-4945 (2023)
Radiomics refers to the conversion of medical imaging into high-throughput, quantifiable data in order to analyse disease patterns, guide prognosis and aid decision making. Radiogenomics is an extension of radiomics that combines conventional radiomi
Externí odkaz:
https://doaj.org/article/14319f84009a49808cf9d208292de260
Autor:
Shaheer I. Khan, Niall J. O’Sullivan, Hugo C. Temperley, Emanuele Rausa, Brian J. Mehigan, Paul McCormick, John O. Larkin, Dara O. Kavanagh, Michael E. Kelly
Publikováno v:
Current Oncology, Vol 30, Iss 1, Pp 416-429 (2022)
Background: Rectal gastrointestinal stromal tumours (GISTs) have many treatment options, but uncertainty remains regarding the best treatment regimen for this rare pathology. The aim of this review is to assess the optimal management approach includi
Externí odkaz:
https://doaj.org/article/4b15f6e245e34a2092bfacbbb19affa8
Autor:
Hugo C. Temperley, Niall J. O’Sullivan, Benjamin M. Mac Curtain, Wanyang Qian, Tatiana S. Temperley, Alannah Murray, Alison Corr, Ian Brennan, David Gallagher, James F. Meaney, Michael E. Kelly
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 5, p 1223 (2024)
Purpose: This systematic review evaluated whole-body MRI (WB-MRI) as a cancer screening tool for individuals carrying germline TP53 mutations, a population known to be at a significantly elevated risk of malignancy. The primary objective is to assess
Externí odkaz:
https://doaj.org/article/873ff2c83339478f8aceb283db492ff9
Autor:
Niall J. O’Sullivan, Hugo C. Temperley, Michelle T. Horan, Alison Corr, Brian J. Mehigan, John O. Larkin, Paul H. McCormick, Dara O. Kavanagh, James F. M. Meaney, Michael E. Kelly
Publikováno v:
Cancers, Vol 15, Iss 24, p 5816 (2023)
Radiogenomics, a sub-domain of radiomics, refers to the prediction of underlying tumour biology using non-invasive imaging markers. This novel technology intends to reduce the high costs, workload and invasiveness associated with traditional genetic
Externí odkaz:
https://doaj.org/article/75c0decbe0b940c4acecaad4d94f653b
Autor:
Croí E. Buckley, Rebecca M. O’Brien, Timothy S. Nugent, Noel E. Donlon, Fiona O’Connell, John V. Reynolds, Adnan Hafeez, Diarmuid S. O’Ríordáin, Robert A. Hannon, Paul Neary, Reza Kalbassi, Brian J. Mehigan, Paul H. McCormick, Cara Dunne, Michael E. Kelly, John O. Larkin, Jacintha O’Sullivan, Niamh Lynam-Lennon
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Resistance to neoadjuvant chemoradiation therapy, is a major challenge in the management of rectal cancer. Increasing evidence supports a role for altered energy metabolism in the resistance of tumours to anti-cancer therapy, suggesting that targetin
Externí odkaz:
https://doaj.org/article/3e43e6fdd76b4196a34b0a99aec3c412
Autor:
Farinaz Ketabat, Titouan Maris, Xiaoman Duan, Zahra Yazdanpanah, Michael E. Kelly, Ildiko Badea, Xiongbiao Chen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Background: Engineering cardiac tissue that mimics the hierarchical structure of cardiac tissue remains challenging, raising the need for developing novel methods capable of creating structures with high complexity. Three-dimensional (3D)-printing te
Externí odkaz:
https://doaj.org/article/05ac7e50b86a492daa626c5511a8ebf2
Autor:
Cian Keogh, Niall J. O’Sullivan, Hugo C. Temperley, Michael P. Flood, Pascallina Ting, Camille Walsh, Peadar Waters, Éanna J. Ryan, John B. Conneely, Aleksandra Edmundson, John O. Larkin, Jacob J. McCormick, Brian J. Mehigan, David Taylor, Satish Warrier, Paul H. McCormick, Mikael L. Soucisse, Craig A. Harris, Alexander G. Heriot, Michael E. Kelly
Publikováno v:
Cancers, Vol 15, Iss 18, p 4469 (2023)
Introduction: Historically, surgical resection for patients with locally recurrent rectal cancer (LRRC) had been reserved for those without metastatic disease. ‘Selective’ patients with limited oligometastatic disease (OMD) (involving the liver a
Externí odkaz:
https://doaj.org/article/7e4301884d3342e285f9f21c121745bf
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionCholangiocarcinoma (CCA) is the most common malignancy affecting the biliary tree. The only curative treatment is surgical resection, aiming for negative margins (R0). For those who have locally advanced disease, which is borderline resec
Externí odkaz:
https://doaj.org/article/cf43449c57744b25825f0586294324d2
Autor:
Sophia Sarpong-Kumankomah, Katherine B. Knox, Michael E. Kelly, Gary Hunter, Bogdan Popescu, Helen Nichol, Karen Kopciuk, Henry Ntanda, Jürgen Gailer
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Advanced analytical methods play an important role in quantifying serum disease biomarkers. The problem of separating thousands of proteins can be reduced by analyzing for a ‘sub-proteome’, such as the ‘metalloproteome’, defined as all protei
Externí odkaz:
https://doaj.org/article/b85f6ea345f04196aec4aa7ff91f2be7