Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael E Wortzman"'
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004517 (2015)
CD4 T cells are critical for control of persistent infections; however, the key signals that regulate CD4 T help during chronic infection remain incompletely defined. While several studies have addressed the role of inhibitory receptors and soluble f
Externí odkaz:
https://doaj.org/article/c19cdb013edc46799dbd027372c9bcff
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68911 (2013)
TNF is an important inflammatory mediator and a target for intervention. TNF is produced by many cell types and is involved in innate inflammation as well as adaptive immune responses. CD8 T cells produce TNF and can also respond to TNF. Deficiency o
Externí odkaz:
https://doaj.org/article/a7db280ed6d94b45a41c850c4978a0c3
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56014 (2013)
NOD2 is an intracellular pattern recognition receptor that provides innate sensing of bacterial muramyl dipeptide by host cells, such as dendritic cells, macrophages and epithelial cells. While NOD2's role as an innate pathogen sensor is well establi
Externí odkaz:
https://doaj.org/article/76f1a4e65a6140f7b1bafd30b0cccc95
Publikováno v:
Mucosal Immunology. 10:1294-1309
The induction of long-lived heterotypic T-cell protection against influenza virus remains elusive, despite the conservation of T-cell epitopes. T-cell protection against influenza is critically dependent on lung-resident memory T cells (Trm). Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea4adf82807e5b6fea32d8da7e22246
https://doi.org/10.1038/mi.2016.124
https://doi.org/10.1038/mi.2016.124
Autor:
Tania H. Watts, Michael Julius, Thomas F. Gajewski, Behrouz Moemeni, Michael E. Wortzman, André Veillette, Marina Vainder, Nathalie Vacaresse
Publikováno v:
Open Journal of Immunology. :244-259
Genomic disruption of Fyn has not been associated with an immune-deficient phenotype, notwithstanding the profound impairment in IL-2 production by T cells derived from Fyn-deficient animals observed in vitro. The results presented demonstrate that F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bf5979f5bc8f5914ef3447e50d06ee
https://doi.org/10.4236/oji.2015.55020
https://doi.org/10.4236/oji.2015.55020
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
CD30 is a tumor necrosis factor receptor (TNFR) family member whose expression is associated with Hodgkin’s disease, anaplastic large cell lymphomas, and other T and B lymphoproliferative disorders in humans. A limited number of studies have assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3977087b271fa6149eb2f938c9dc57
http://europepmc.org/articles/PMC5622170
http://europepmc.org/articles/PMC5622170
Publikováno v:
The Journal of Immunology. 190:4627-4639
The TNFR family member 4-1BB plays a key role in the survival of activated and memory CD8 T cells. However, the mechanisms that regulate 4-1BB re-expression on memory CD8 T cells after Ag clearance are unknown. In unimmunized mice, ∼10% of CD8 CD44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386738b5cecf9a56b58035588ad6a487
https://doi.org/10.4049/jimmunol.1201854
https://doi.org/10.4049/jimmunol.1201854
Autor:
Ivan Tattoli, Michael E. Wortzman, Dana J. Philpott, Damien Arnoult, Fraser Soares, Stephen E. Girardin
Publikováno v:
Innate Immunity. 19:438-448
NLRX1 is a member of the Nod-like receptor family of intracellular sensors of microbial- and danger-associated molecular patterns. NLRX1 has a N-terminal mitochondrial addressing sequence that localizes the protein to the mitochondrial matrix. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfe79073b346bd595615bdf1939293a
https://doi.org/10.1177/1753425912467383
https://doi.org/10.1177/1753425912467383
Autor:
Mariana Vidric, Katrin Roth, Achire N. Mbanwi, Fanny Edele, Anja E. Hauser, Gloria H. Y. Lin, Michael E. Wortzman, Tania H. Watts, Laura M. Snell
Publikováno v:
European Journal of Immunology. 42:2861-2874
The persistence of memory lymphocytes is a critical feature of adaptive immunity. The TNF family ligand 4-1BBL supports the antigen-independent survival of CD8⁺ memory T cells. Here, we show that mice lacking 4-1BB only on αβ T cells show a simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9bbe69db40ee619d3c113e6ab789d8d
https://doi.org/10.1002/eji.201242503
https://doi.org/10.1002/eji.201242503
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e68911 (2013)
PLoS ONE, Vol 8, Iss 7, p e68911 (2013)
TNF is an important inflammatory mediator and a target for intervention. TNF is produced by many cell types and is involved in innate inflammation as well as adaptive immune responses. CD8 T cells produce TNF and can also respond to TNF. Deficiency o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dd70d4caf84fa71530a7edfcfec438
https://pubmed.ncbi.nlm.nih.gov/23874808
https://pubmed.ncbi.nlm.nih.gov/23874808