Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Michael E Weale"'
Autor:
Natalie J Prescott, Benjamin Lehne, Kristina Stone, James C Lee, Kirstin Taylor, Jo Knight, Efterpi Papouli, Muddassar M Mirza, Michael A Simpson, Sarah L Spain, Grace Lu, Franca Fraternali, Suzannah J Bumpstead, Emma Gray, Ariella Amar, Hannah Bye, Peter Green, Guy Chung-Faye, Bu'Hussain Hayee, Richard Pollok, Jack Satsangi, Miles Parkes, Jeffrey C Barrett, John C Mansfield, Jeremy Sanderson, Cathryn M Lewis, Michael E Weale, Thomas Schlitt, Christopher G Mathew, UK IBD Genetics Consortium
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004955 (2015)
The contribution of rare coding sequence variants to genetic susceptibility in complex disorders is an important but unresolved question. Most studies thus far have investigated a limited number of genes from regions which contain common disease asso
Externí odkaz:
https://doaj.org/article/3034006484b2454399b4760e82e0114d
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98122 (2014)
The increasing quantity and quality of functional genomic information motivate the assessment and integration of these data with association data, including data originating from genome-wide association studies (GWAS). We used previously described GW
Externí odkaz:
https://doaj.org/article/dea5727b86e64406a5dada1990ec3ec6
Autor:
Daniah Trabzuni, Mina Ryten, Warren Emmett, Adaikalavan Ramasamy, Karl J Lackner, Tanja Zeller, Robert Walker, Colin Smith, Patrick A Lewis, Adamantios Mamais, Rohan de Silva, Jana Vandrovcova, International Parkinson Disease Genomics Consortium (IPDGC), Dena Hernandez, Michael A Nalls, Manu Sharma, Sophie Garnier, Suzanne Lesage, Javier Simon-Sanchez, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew Singleton, Huaibin Cai, Eric Schadt, Nicholas W Wood, Rina Bandopadhyay, Michael E Weale, John Hardy, Vincent Plagnol
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70724 (2013)
Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy. However, little is known about the molecular mechanisms mediating these effects. To further characterize this locus
Externí odkaz:
https://doaj.org/article/aa919c6789b341e69f7b3a79a679c38a
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e14808 (2011)
A genome wide association study (GWAS) typically results in a few highly significant 'hits' and a much larger set of suggestive signals ('near-hits'). The latter group are expected to be a mixture of true and false associations. One promising strateg
Externí odkaz:
https://doaj.org/article/970b289069ce4d67b3665b2c8ae01991
Autor:
Anna C Need, Dongliang Ge, Michael E Weale, Jessica Maia, Sheng Feng, Erin L Heinzen, Kevin V Shianna, Woohyun Yoon, Dalia Kasperaviciūte, Massimo Gennarelli, Warren J Strittmatter, Cristian Bonvicini, Giuseppe Rossi, Karu Jayathilake, Philip A Cola, Joseph P McEvoy, Richard S E Keefe, Elizabeth M C Fisher, Pamela L St Jean, Ina Giegling, Annette M Hartmann, Hans-Jürgen Möller, Andreas Ruppert, Gillian Fraser, Caroline Crombie, Lefkos T Middleton, David St Clair, Allen D Roses, Pierandrea Muglia, Clyde Francks, Dan Rujescu, Herbert Y Meltzer, David B Goldstein
Publikováno v:
PLoS Genetics, Vol 5, Iss 2, p e1000373 (2009)
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and 863 controls, following up the top hits in four independent cohorts comprising
Externí odkaz:
https://doaj.org/article/c19e84d31375449d8e0177d2a66e2fc4
Autor:
Karishma D’Sa, Sebastian Guelfi, Jana Vandrovcova, Regina H. Reynolds, David Zhang, John Hardy, Juan A. Botía, Michael E. Weale, Sarah A. Gagliano Taliun, Kerrin S. Small, Mina Ryten
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Gaining insight into the genetic regulation of gene expression in human brain is key to the interpretation of genome-wide association studies for major neurological and neuropsychiatric diseases. Expression quantitative trait loci (eQTL) ana
Externí odkaz:
https://doaj.org/article/7814aaf031334f36bd0441a657c5d4ad
Autor:
Karishma D’Sa, Sebastian Guelfi, Jana Vandrovcova, Regina H. Reynolds, David Zhang, John Hardy, Juan A. Botía, Michael E. Weale, Sarah A. Gagliano Taliun, Kerrin S. Small, Mina Ryten
Gaining insight into the genetic regulation of gene expression in human brain is key to the interpretation of genome-wide association studies for major neurological and neuropsychiatric diseases. Expression quantitative trait loci (eQTL) analyses hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ebe1268e7e745e99327c787cb60b7c
https://doi.org/10.1101/2022.06.28.497921
https://doi.org/10.1101/2022.06.28.497921
Autor:
Joshua W. Knowles, Carla Giner-Delgado, Alexander S. Lachapelle, Fernando Riveros-Mckay, Ayden Saffari, Shoa L. Clarke, Gil McVean, Saskia Selzam, Euan A. Ashley, Priyanka Seth, Hannah Wand, William A. Tarran, R. Michael Sivley, Duncan S. Palmer, Vincent Plagnol, Daniel Wells, Eva Gradovich, Peter Donnelly, Jack W. O’Sullivan, Rachel Moore, Michael E. Weale
Publikováno v:
The American Journal of Cardiology. 148:157-164
The American College of Cardiology / American Heart Association pooled cohort equations tool (ASCVD-PCE) is currently recommended to assess 10-year risk for atherosclerotic cardiovascular disease (ASCVD). ASCVD-PCE does not currently include genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f95903e710a96530ff302329553a788
https://doi.org/10.1016/j.amjcard.2021.02.032
https://doi.org/10.1016/j.amjcard.2021.02.032
Autor:
Carla Giner Delgado, Eva Gradovich, R. Michael Sivley, Karola Rehnstrom, Andreas Heger, William Tarran, Alexander Lachapelle, Peter Donnelly, Michael E Weale, Gilean McVean, Priyanka Seth, Vincent Plagnol
Publikováno v:
Circulation. 144
Genetic risk factors contribute to cardiovascular disease (CVD) risk and are imperfectly captured by family history. The development of integrated risk tools (IRT) that integrate polygenic risk scores (PRS) with conventional risk factors enables impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c5f338fed9188617d03dbfde80ac581
https://doi.org/10.1161/circ.144.suppl_1.11316
https://doi.org/10.1161/circ.144.suppl_1.11316
Autor:
Fernando Riveros-Mckay, Saskia Selzam, Priyanka Seth, Rachel Moore, William A Tarran, Jack W O'Sullivan, Euan A Ashley, Gilean McVean, Vincent Plagnol, Peter Donnelly, Michael E Weale
Publikováno v:
Circulation. 144
Risk-guided intervention in the US, informed by the pooled cohort equations (PCE) risk calculator, is the accepted practice for prevention of atherosclerotic cardiovascular disease (ASCVD). We recently showed that a polygenic risk score (PRS, summari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b56ad4d3b9a03fc891a78a4be0e6bd5
https://doi.org/10.1161/circ.144.suppl_1.12101
https://doi.org/10.1161/circ.144.suppl_1.12101