Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Michael E Stokes"'
Autor:
Michael E Stokes, Peter eMcCourt
Publikováno v:
Frontiers in Plant Science, Vol 5 (2014)
In contrast to the dominant drug paradigm in which compounds were developed to fit all, new models focused around personalized medicine are appearing where treatments are customized for individual patients. The agricultural biotechnology industry sho
Externí odkaz:
https://doaj.org/article/50f8216e27d14a64acf0a353380203d8
Autor:
Michael E. Stokes, Matthew D. Surman, Veronica Calvo, David Surguladze, An-Hu Li, Jennifer Gasparek, Matthew Betzenhauser, Guangyu Zhu, Hongwen Du, Alan C. Rigby, Mark J. Mulvihill
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2233 (2022)
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK h
Externí odkaz:
https://doaj.org/article/bfdce10972624d15be3669c45666742f
Autor:
Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3411-3423.e7 (2020)
Summary: Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to selectively stain ferroptotic cells in tissue sections to ch
Externí odkaz:
https://doaj.org/article/c63fa17fdc6c49d3bd4dbc9c3951b70a
Publikováno v:
Obesity. 29:1950-1960
OBJECTIVE This study assessed the impact of diabetes mellitus (DM) on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with advanced fibrosis prevalence in adults with overweight or obesity in the United States. METHOD
Autor:
Michael E. Stokes, Veronica Calvo, Crissy Dudgeon, Sho Fujisawa, Sharon Huang, Leyi Shen, Nupur Ballal, Joe McGinley, David Liu, Mark J. Mulvihill, Alan C. Rigby, Nandita Bose, Eric S. Lightcap, David Surguladze
Publikováno v:
Cancer Research. 83:4010-4010
Anti-angiogenic agents form the backbone of standard of care for advanced clear cell renal cell carcinoma (ccRCC), but their clinical impact is limited by primary and secondary resistance mechanisms that remain a critical problem. Furthermore, the ap
Autor:
Alyssa M. Klein, Donald C. Lo, Denise E. Dunn, Christopher J. Chang, Divya Venkatesh, David R. Tong, Sung-Hwan Moon, Everett S. Kengmana, Joleen M. Csuka, Brent R. Stockwell, Fereshteh Zandkarimi, Angelo D'Alessandro, Allegra T. Aron, Carol Prives, Nicholas A. O'Brien, Michael E. Stokes, Marcus Conrad
Publikováno v:
Genes & development, vol 34, iss 7-8
Genes Dev
Genes Dev
MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic roles in cells, tissues, and animals that are independent of p53. There is less
Publikováno v:
Chest. 162:A2337
Autor:
Hengrui Liu, Sho Iketani, Arie Zask, Nisha Khanizeman, Eva Bednarova, Farhad Forouhar, Brandon Fowler, Seo Jung Hong, Hiroshi Mohri, Manoj S. Nair, Yaoxing Huang, Nicholas E. S. Tay, Sumin Lee, Charles Karan, Samuel J. Resnick, Colette Quinn, Wenjing Li, Henry Shion, Xin Xia, Jacob D. Daniels, Michelle Bartolo-Cruz, Marcelo Farina, Presha Rajbhandari, Christopher Jurtschenko, Matthew A. Lauber, Thomas McDonald, Michael E. Stokes, Brett L. Hurst, Tomislav Rovis, Alejandro Chavez, David D. Ho, Brent R. Stockwell
Publikováno v:
Nature communications. 13(1)
The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral maturation and replication cycle. Based on the conservation of 3CL protease substrate binding pocke
Autor:
Michael E. Stokes, Jonnell Candice Small, Brent R. Stockwell, Andrea Califano, Kenichi Shimada, Tal Hirschhorn, Alessandro Vasciaveo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
The identification of targeted agents with high therapeutic index is a major challenge for cancer drug discovery. We found that screening chemical libraries across neuroblastoma (NBL) tumor subtypes for selectively-lethal compounds revealed metabolic
Publikováno v:
Journal of the Endocrine Society
Non-alcoholic fatty liver disease (NAFLD) is the most common, chronic liver disorder in the United States (US). Non-alcoholic steatohepatitis (NASH), the more severe form of NAFLD with hepatocyte necroinflammation that may lead to cirrhosis and hepat