Zobrazeno 1 - 10
of 413
pro vyhledávání: '"Michael E Pichichero"'
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257207 (2021)
Streptococcus pneumoniae (Spn) is a leading respiratory tract pathogen that colonizes the nasopharynx (NP) through adhesion to epithelial cells and immune evasion. Spn actively interacts with other microbiota in NP but the nature of these interaction
Externí odkaz:
https://doaj.org/article/49ddef9ada764c9995e159f51afe2010
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243942 (2020)
Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical
Externí odkaz:
https://doaj.org/article/c5070e2caa674db8be22feb86b0e7669
Autor:
Jonathan C Thomas, Marisol Figueira, Kristopher P Fennie, Alison S Laufer, Yong Kong, Michael E Pichichero, Stephen I Pelton, Melinda M Pettigrew
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18649 (2011)
Streptococcus pneumoniae is an important cause of otitis media and invasive disease. Since introduction of the heptavalent pneumococcal conjugate vaccine, there has been an increase in replacement disease due to serotype 19A clonal complex (CC)199 is
Externí odkaz:
https://doaj.org/article/89764ed9bf9347dbbf4070e4e9bec13e
Autor:
Michael Shaffer, Katharine Best, Catherine Tang, Xue Liang, Steven Schulz, Eduardo Gonzalez, Cory H. White, Thomas P. Wyche, John Kang, Hendrik Wesseling, Begüm D. Topçuoğlu, Thomas Cairns, Theodore R. Sana, Robin M. Kaufhold, Julia M. Maritz, Christopher H. Woelk, Gokul Swaminathan, James E. Norton, Michael E. Pichichero
Publikováno v:
mSystems, Vol 8, Iss 5 (2023)
ABSTRACT Despite multiple vaccine doses early in life, a substantial proportion of infants do not mount protective responses. In this study, we followed a cohort of children over the first 2 years of life, collecting microbiome and metabolome data lo
Externí odkaz:
https://doaj.org/article/e7ffdf61323e4b3cbd3a8d0ab3ea26a1
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 12, Pp 3201-3207 (2020)
Since their widespread use, pneumococcal conjugate vaccines (PCVs) have proven effective at reducing both invasive and noninvasive pneumococcal diseases and nasopharyngeal carriage of Streptococcus pneumoniae (Spn). To establish this level of protect
Externí odkaz:
https://doaj.org/article/0393dab3c438404d8473261addf3f98e
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 12, Pp 3194-3200 (2020)
Conserved Moraxella catarrhalis (Mcat) proteins, oligopeptide permease (Opp)A, hemagglutinin (Hag), outer membrane protein (OMP) CD, Pilin A clade 2 (PilA2), and Moraxella surface protein (Msp) 22 have been studied as vaccine candidates. Children who
Externí odkaz:
https://doaj.org/article/20c5d41c3714488bb8125274540afa97
Autor:
Michael E. Pichichero
Publikováno v:
Expert Review of Vaccines, Vol 16, Iss 12, Pp 1181-1190 (2017)
Introduction: Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need
Externí odkaz:
https://doaj.org/article/56fd643e67fa4ed68fef96d67c5475cb
Autor:
Seth P, Jones, Kali H, Cook, Melody L, Holmquist, Liam J, Almekinder, Annie M, Delaney, Ryhl, Charles, Natalie, Labbe, Janai, Perdue, Niaya, Jackson, Michael E, Pichichero, Ravinder, Kaur, Lea V, Michel, Michael L, Gleghorn
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 91:161-170
We have determined the 1.8 Å X-ray crystal structure of nonlipidated (i.e., N-terminally truncated) nontypeable Haemophilus influenzae (NTHi; H. influenzae) protein D. Protein D exists on outer membranes of H. influenzae strains and acts as a virule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724b8c6d97bd3b55f8ebea77bbed58e7
https://doi.org/10.1002/prot.26418
https://doi.org/10.1002/prot.26418
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 10, Pp 2316-2321 (2017)
Background Clinical trials of vaccines for children to prevent acute otitis media (AOM) infections caused by the bacteria Streptococcus pneumonia (Spn) are in Phase I. The objective of this study was to use serum antibody measurements to pneumococcal
Externí odkaz:
https://doaj.org/article/f7ef9ddd3ea449d3a84991cd79c2396d
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Acute otitis media (AOM) is the most common pediatric infection for which antibiotics are prescribed in the United States. The role of the respiratory tract microbiome in pathogenesis and immune modulation of AOM remains unexplored. We sought to comp
Externí odkaz:
https://doaj.org/article/d4352611e48a4670a75ca77011272123