Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Michael E Greenberg"'
Publikováno v:
eLife, Vol 11 (2022)
Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations. However, it remains difficult to predict precisely the effect of any given sequence variant
Externí odkaz:
https://doaj.org/article/637ec108529642a3a214676a933beab7
Autor:
Sinisa Hrvatin, Christopher P Tzeng, M Aurel Nagy, Hume Stroud, Charalampia Koutsioumpa, Oren F Wilcox, Elena G Assad, Jonathan Green, Christopher D Harvey, Eric C Griffith, Michael E Greenberg
Publikováno v:
eLife, Vol 8 (2019)
Enhancers are the primary DNA regulatory elements that confer cell type specificity of gene expression. Recent studies characterizing individual enhancers have revealed their potential to direct heterologous gene expression in a highly cell-type-spec
Externí odkaz:
https://doaj.org/article/9e25154002544c1190234773b67776a3
Autor:
Michael W Susman, Edith P Karuna, Ryan C Kunz, Taranjit S Gujral, Andrea V Cantú, Shannon S Choi, Brigette Y Jong, Kyoko Okada, Michael K Scales, Jennie Hum, Linda S Hu, Marc W Kirschner, Ryuichi Nishinakamura, Soichiro Yamada, Diana J Laird, Li-En Jao, Steven P Gygi, Michael E Greenberg, Hsin-Yi Henry Ho
Publikováno v:
eLife, Vol 6 (2017)
Wnt5a-Ror signaling constitutes a developmental pathway crucial for embryonic tissue morphogenesis, reproduction and adult tissue regeneration, yet the molecular mechanisms by which the Wnt5a-Ror pathway mediates these processes are largely unknown.
Externí odkaz:
https://doaj.org/article/275601caa693448db8ac74e33e0585f8
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The mammalian central nervous system coordinates a network of signaling pathways and cellular interactions, which enable a myriad of complex cognitive and physiological functions. While traditional efforts to understand the molecular basis of brain f
Externí odkaz:
https://doaj.org/article/3eb5e1a5548540d99b3d5c3a0697254a
Autor:
Maria H Chahrour, Timothy W Yu, Elaine T Lim, Bulent Ataman, Michael E Coulter, R Sean Hill, Christine R Stevens, Christian R Schubert, ARRA Autism Sequencing Collaboration, Michael E Greenberg, Stacey B Gabriel, Christopher A Walsh
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002635 (2012)
Although autism has a clear genetic component, the high genetic heterogeneity of the disorder has been a challenge for the identification of causative genes. We used homozygosity analysis to identify probands from nonconsanguineous families that show
Externí odkaz:
https://doaj.org/article/2902585976fa4160a7a77dc60c4d5f5a
Autor:
Elizabeth A. Pollina, Daniel T. Gilliam, Andrew T. Landau, Cindy Lin, Naomi Pajarillo, Christopher P. Davis, David A. Harmin, Ee-Lynn Yap, Ian R. Vogel, Eric C. Griffith, M. Aurel Nagy, Emi Ling, Erin E. Duffy, Bernardo L. Sabatini, Charles J. Weitz, Michael E. Greenberg
Publikováno v:
Nature. 614:732-741
Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the stability of the genome across the long lifespan of postmitotic neurons1–5. Whether neurons have acquired specialized genome protection mechanisms that
Publikováno v:
Nature. 609:327-334
In the hippocampus, spatial maps are formed by place cells while contextual memories are thought to be encoded as engrams1–6. Engrams are typically identified by expression of the immediate early gene Fos, but little is known about the neural activ
Autor:
Erin E. Duffy, Benjamin Finander, GiHun Choi, Ava C. Carter, Iva Pritisanac, Aqsa Alam, Victor Luria, Amir Karger, William Phu, Maxwell A. Sherman, Elena G. Assad, Naomi Pajarillo, Alexandra Khitun, Elizabeth E. Crouch, Sanika Ganesh, Jin Chen, Bonnie Berger, Nenad Sestan, Anne O’Donnell-Luria, Eric J. Huang, Eric C. Griffith, Julie D. Forman-Kay, Alan M. Moses, Brian T. Kalish, Michael E. Greenberg
Publikováno v:
Nature neuroscience, vol 25, iss 10
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the developing human brain, there is a gap in understanding of accompanying trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1812dea783a335dcb51a8256cbbf1
https://escholarship.org/uc/item/6gc2q79k
https://escholarship.org/uc/item/6gc2q79k
Publikováno v:
eLife. 11
Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations. However, it remains difficult to predict precisely the effect of any given sequence variant