Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael E Fusakio"'
Autor:
Jochen Mattner, Javid P Mohammed, Michael E Fusakio, Claudia Giessler, Carl-Philipp Hackstein, Robert Opoka, Marius Wrage, Regina Schey, Jan Clark, Heather I Fraser, Daniel B Rainbow, Linda S Wicker
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008178 (2019)
Type 1 diabetes (T1D) is a chronic multi-factorial disorder characterized by the immune-mediated destruction of insulin-producing pancreatic beta cells. Variations at a large number of genes influence susceptibility to spontaneous autoimmune T1D in n
Externí odkaz:
https://doaj.org/article/68695eaca1e54bc6800377987faee9a5
Autor:
Yongping Wang, Christopher M. Adams, Ronald C. Wek, Jeffrey A. Willy, Rana J. T. Al Baghdadi, Michael E. Fusakio, Emily T. Mirek, Tracy G. Anthony
Publikováno v:
Molecular Biology of the Cell
Whole-body and liver-specific ATF4–knockout mice are used to evaluate the role of ATF4 transcription factor in the unfolded protein response (UPR). ATF4 directs a small subset of UPR gene expression, and deletion of ATF4 in the liver triggers enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc652cf1a2f1961e473d692f141cc50
http://europepmc.org/articles/PMC4850040
http://europepmc.org/articles/PMC4850040
Autor:
Jeanette N. McClintick, Thomas D. Baird, Lakshmi Reddy Palam, Jeffrey A. Willy, Ronald C. Wek, Tracy G. Anthony, Michael E. Fusakio, Christopher M. Davis
Publikováno v:
Molecular Biology of the Cell
This study measured changes in global mRNA translation in response to ER stress. The analysis suggests that translation of a majority of gene transcripts is either repressed or resistant, whereas select key regulators are subject to preferential tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb3c50852e91b3366e8b9a035201794
https://doi.org/10.1091/mbc.e14-02-0704
https://doi.org/10.1091/mbc.e14-02-0704
Autor:
Michael S. Kilberg, B. Teske, Jeanette N. McClintick, Ronald C. Wek, Michael E. Fusakio, Donghui Zhou, Jixiu Shan
Publikováno v:
Molecular Biology of the Cell
This study addresses the mechanisms by which CHOP directs gene regulatory networks and determines cell fate. Transcriptional expression of ATF5 is activated by both CHOP and ATF4 in the integrated stress response. CHOP and ATF5 control a switch to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214b7e680617441aa3fb14a9caef78db
http://europepmc.org/articles/PMC3727939
http://europepmc.org/articles/PMC3727939
Autor:
Jörg Köhl, Yves Laumonnier, Kasper Hoebe, Javid P. Mohammed, Jochen Mattner, Michael E. Fusakio
Publikováno v:
The Journal of Immunology. 187:5805-5812
Complement, NKT, and NK cells play critical roles in the first line defense against pathogens. Functional roles for both C5a receptors, that is, complement receptor C5a (C5aR) and C5a receptor-like 2 (C5L2), in sepsis have been demonstrated. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69446db3855ab33536ed26c7cf701cec
https://doi.org/10.4049/jimmunol.1100338
https://doi.org/10.4049/jimmunol.1100338
Autor:
Brittany A. Lennox, Tracy G. Anthony, Emily T. Mirek, Pengxiang She, Michael E. Fusakio, Ronald C. Wek, Gabriel J. Wilson, Gregory C. Henderson, Rana J. T. Al Baghdadi, Joseph L. Dixon
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 308(4)
The antileukemic agent asparaginase triggers the amino acid response (AAR) in the liver by activating the eukaryotic initiation factor 2 (eIF2) kinase general control nonderepressible 2 (GCN2). To explore the mechanism by which AAR induction is neces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05aaba24f97d77f92e6ca3ac6f7dd432
https://pubmed.ncbi.nlm.nih.gov/25491724
https://pubmed.ncbi.nlm.nih.gov/25491724
Autor:
Javid P. Mohammed, Daniel B. Rainbow, Marsha Wills-Karp, Paul B. Savage, Carolyn Moule, Laurence B. Peterson, John A. Todd, William M. Ridgway, Jan Clark, Linda S. Wicker, Jochen Mattner, Heather I. Fraser, Michael E. Fusakio
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(1)
Environmental and genetic factors define the susceptibility of an individual to autoimmune disease. Although common genetic pathways affect general immunological tolerance mechanisms in autoimmunity, the effects of such genes could vary under distinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a4424c77e974aac42dbc7e2fb00fd9
https://pubmed.ncbi.nlm.nih.gov/21613619
https://pubmed.ncbi.nlm.nih.gov/21613619
Autor:
Emma L. Masteller, Val Moody, Heather I. Fraser, Javid P. Mohammed, Linda S. Wicker, Jan Clark, Michael E. Fusakio, Daniel B. Rainbow, Oliver S. Burren, Laurence B. Peterson, Mikkel B. Christensen, Jeffrey A. Bluestone, Dieter Naf, Frank Koentgen, Erik B. Finger, Carolyn Moule, J. P. Houchins, John A. Todd, Jochen Mattner, Charles A. Steward, William M. Ridgway, Sarah Howlett
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(1)
We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640488d10f3b9d90bd804f433708bfda
https://pubmed.ncbi.nlm.nih.gov/21613616
https://pubmed.ncbi.nlm.nih.gov/21613616
Autor:
Michael E. Fusakio, Javid P. Mohammed, Jörg Köhl, Yves Laumonnier, Jochen Mattner, Kasper Hoebe
Publikováno v:
Molecular Immunology. 48:1672
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbea2f70278c1ea184608226fbcc3eae
https://doi.org/10.1016/j.molimm.2011.06.239
https://doi.org/10.1016/j.molimm.2011.06.239