Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Michael E Davis"'
Autor:
Chiemela Ohanele, Jessica N. Peoples, Anja Karlstaedt, Joshua T. Geiger, Ashley D. Gayle, Nasab Ghazal, Fateemaa Sohani, Milton E. Brown, Michael E. Davis, George A. Porter, Victor Faundez, Jennifer Q. Kwong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The developing mammalian heart undergoes an important metabolic shift from glycolysis towards mitochondrial oxidation that is critical to support the increasing energetic demands of the maturing heart. Here, we describe a new mechanistic lin
Externí odkaz:
https://doaj.org/article/303b6bcf721b461cb58adc8d83829c32
Autor:
John M. Kelly, MD, Zinan Hu, BS, Felipe Takaesu, BS, Tatsuya Watanabe, MD, PhD, Judd Storrs, PhD, Benjamin Blais, MD, Satoshi Yuhara, MD, Adrienne Morrison, BA, Kirsten Nelson, BA, Anudari Ulziibayar, MD, Eric Heuer, BA, Cole Anderson, BS, Michael Jimenez, BA, Joseph Leland, BA, Raphael Malbrue, DVM, Carmen Arsuaga-Zorrilla, DVM, MS, Laurie Goodchild, DVM, Aymen Naguib, MD, Christopher McKee, MD, Jordan Varner, BA, Cameron DeShetler, BS, Joshua Spiess, BA, Andrew Harrison, BA, Brian Boe, MD, Aimee K. Armstrong, MD, Arash Salavitabar, MD, Kan Hor, MD, Rajesh Krishnamurthy, MD, Andrew R. Yates, MD, Toshiharu Shinoka, MD, PhD, Sergio A. Carrillo, MD, Michael E. Davis, PhD, Alison L. Marsden, PhD, Christopher K. Breuer, MD
Publikováno v:
JTCVS Open, Vol 21, Iss , Pp 268-278 (2024)
Objectives: Our goal was to conduct a hemodynamic analysis of a novel animal model of Fontan physiology. Poor late-term outcomes in Fontan patients are believed to arise from Fontan-induced hemodynamics, but the mechanisms remain poorly understood. R
Externí odkaz:
https://doaj.org/article/0dd841fd94ee42ae8ce14d5209eb6770
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124962 (2015)
Secretory factors in animals play an important role in communication between different cells, tissues and organs. Especially, the secretory factors with specific expression in one tissue may reflect important functions and unique status of that tissu
Externí odkaz:
https://doaj.org/article/09bd8a3d6ae943e097e31f1143239bca
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64483 (2013)
Understanding the tissue-specific pattern of gene expression is critical in elucidating the molecular mechanisms of tissue development, gene function, and transcriptional regulations of biological processes. Although tissue-specific gene expression i
Externí odkaz:
https://doaj.org/article/dea9dcf0641d4726b656fa5992353f03
Autor:
Apoorva S Salimath, Edward A Phelps, Archana V Boopathy, Pao-lin Che, Milton Brown, Andrés J García, Michael E Davis
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50980 (2012)
Acute myocardial infarction (MI) caused by ischemia and reperfusion (IR) is the most common cause of cardiac dysfunction due to local cell death and a temporally regulated inflammatory response. Current therapeutics are limited by delivery vehicles t
Externí odkaz:
https://doaj.org/article/c69a3f7d42f74d619d891553e2adab94
Autor:
Jessica R. Hoffman, Hyun-Ji Park, Sruti Bheri, Manu O. Platt, Joshua M. Hare, Sunjay Kaushal, Judith L. Bettencourt, Dejian Lai, Timothy C. Slesnick, William T. Mahle, Michael E. Davis
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107980- (2023)
Summary: Cardiac-derived c-kit+ progenitor cells (CPCs) are under investigation in the CHILD phase I clinical trial (NCT03406884) for the treatment of hypoplastic left heart syndrome (HLHS). The therapeutic efficacy of CPCs can be attributed to the r
Externí odkaz:
https://doaj.org/article/c98aba44087c46edbb4851a882473aa8
Autor:
Muthukumar Gunasekaran, Rachana Mishra, Progyaparamita Saha, David Morales, Wen-Chih Cheng, Arun R. Jayaraman, Jessica R. Hoffman, Lauran Davidson, Ling Chen, Aakash M. Shah, Gregory Bittle, Xuebin Fu, Antariksh Tulshyan, Mohamed Abdullah, Tami Kingsbury, Curt Civin, Peixin Yang, Michael E. Davis, Roberto Bolli, Joshua M. Hare, Sudhish Sharma, Sunjay Kaushal
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104656- (2022)
Summary: Successful cell therapy requires cells to resist the hostile ischemic myocardium, be retained to continue secreting cardioprotective growth factors/exosomes, and resist immunological host responses. Clinically relevant stem/progenitor cells
Externí odkaz:
https://doaj.org/article/cfa3170dcc4846bba20f01a55e64e98d
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 11, p 374 (2022)
Human cardiac-derived c-kit+ stromal cells (CSCs) have demonstrated efficacy in preclinical trials for the treatment of heart failure and myocardial dysfunction. Unfortunately, large variability in patient outcomes and cell populations remains a prob
Externí odkaz:
https://doaj.org/article/aaa2b868372c4fceb2c738b056c67144
Autor:
Hyun-Ji Park, John M. Kelly, Jessica R. Hoffman, Felipe Takaesu, William Schwartzman, Anudari Ulziibayar, Takahiro Kitsuka, Eric Heuer, Asigul Yimit, Raphael Malbrue, Cole Anderson, Adrienne Morrison, Aymen Naguib, Christopher Mckee, Andrew Harrison, Brian Boe, Aimee Armstrong, Arash Salavitabar, Andrew Yates, Toshiharu Shinoka, Sergio Carrillo, Christopher K. Breuer, Michael E. Davis
Publikováno v:
Extracellular vesicle. 1
Patients with single ventricle heart defects requires a series of staged open-heart procedures, termed Fontan palliation. However, while lifesaving, these operations are associated with significant morbidity and early mortality. The attendant complic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f56675260b5bc62ace9f472dcdcf45b
https://pubmed.ncbi.nlm.nih.gov/36330420
https://pubmed.ncbi.nlm.nih.gov/36330420
Autor:
David Trac, Jessica R. Hoffman, Sruti Bheri, Joshua T. Maxwell, Manu O. Platt, Michael E. Davis
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1212-1221 (2019)
Abstract Congenital heart disease can lead to severe right ventricular heart failure (RVHF). We have shown that aggregated c‐kit+ progenitor cells (CPCs) can improve RVHF repair, likely due to exosome‐mediated effects. Here, we demonstrate that m
Externí odkaz:
https://doaj.org/article/f5b11caa85804aea85990bcbed1580e9