Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael E Cunningham"'
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5624 (2009)
The orphan nuclear receptor estrogen-related receptor alpha (ERRalpha) is a member of the nuclear receptor superfamily. It was identified through a search for genes encoding proteins related to estrogen receptor alpha (ERalpha). An endogenous ligand
Externí odkaz:
https://doaj.org/article/ed8a3f51a2924496a2d2725845007fee
Autor:
Michael E. Cunningham, Wayne A. Churaman, Nicholas W. Piekiel, Luke J. Currano, David M. Lunking, Christopher J. Morris
Publikováno v:
Propellants, Explosives, Pyrotechnics. 40:16-26
We present a comprehensive investigation into the tunable combustion of on-chip porous silicon energetic materials. The exothermic reaction occurs between high surface area nanoscale porous silicon and a solution-deposited sodium perchlorate oxidizer
Autor:
Betty J. Tsuei, Eric W. Mueller, Lindsey Clark, Michael E. Cunningham, Chris Droege, Abigail T. Burka, Neil Ernst, Kristen Hillebrand
Publikováno v:
Critical Care Medicine. 40:1-328
Autor:
Nicole Trainor, E V Lis, Anthony G. DiLella, Terrence P. McDonald, Annie Liang, Mark E. Layton, Duane R. Reiss, Michael J. Kelly, Sanderson Philip E, James Yergey, Kevin J. Rodzinak, Steven D. Young, Guy R. Seabrook, Christine Fandozzi, Michael E. Cunningham, Scott D. Mosser, Mark O. Urban, John F. Fay, Hao Wang, Kenneth S. Koblan, Rodney A. Bednar
Publikováno v:
ACS Chemical Neuroscience. 2:352-362
A series of 3-substituted aminocyclopentanes has been identified as highly potent and selective NR2B receptor antagonists. Incorporation of a 1,2,4-oxadiazole linker and substitution of the pendant phenyl ring led to the discovery of orally bioavaila
Autor:
Bohumil Bednar, Oleg Kornienko, Marianna Kapitskaya, Konstantin Petrukhin, Michael E. Cunningham, Raul Lacson
Publikováno v:
ASSAY and Drug Development Technologies. 4:253-262
Retina-specific nuclear receptor (RNR), also known as PNR and NR2E3, is an orphan nuclear receptor expressed exclusively in photoreceptor cells of the retina. Here we describe homogeneous cell-based resonance energy transfer assay for identification
Publikováno v:
Cytometry Part A. :133-139
Background Modern drug discovery has been based on high-throughput screening using whole-cell assays. A prominent role has been assigned to the reporter gene technology based on a β-lactamase and the fluorogenic substrate CCF2. Successful applicatio
Autor:
John A. McCauley, Gong Cheng, Laszlo Kiss, Michael E. Cunningham, Nigel J. Liverton, Bohumil Bednar, Kenneth S. Koblan
Publikováno v:
Journal of Neuroscience Methods. 137:247-255
To facilitate the discovery of novel N-methyl-d-aspartate (NMDA) receptor antagonists, we have developed a high-throughput functional assay based on fluorescence detection of free intracellular calcium concentrations. Mouse fibroblast L(tk-) cells ex
Publikováno v:
Journal of Diagnostic Medical Sonography. 18:31-34
Varicoceles are a frequently identified pathology noted within the scrotum. Sonographically, they present as dilated vascular structures within the spermatic cord. Real-time pulsed-wave Doppler imaging reveals these structures as venous in nature. Ma
Publikováno v:
Journal of Biological Chemistry. 274:25301-25307
Agonist-generated inside-out signals enable the platelet integrin alpha(IIb)beta(3) to bind soluble ligands such as fibrinogen. We found that inhibiting actin polymerization in unstimulated platelets with cytochalasin D or latrunculin A mimics the ef
Autor:
Patricia A. Jumes, Bohumil Bednar, Rodney A. Bednar, George D. Hartman, Marie A. Holahan, Robert J. Gould, Jacquelynn J. Cook, Michael E. Cunningham
Publikováno v:
Blood. 94:587-599
Most clinical trials with fibrinogen receptor antagonists (FRAs) have been associated with thrombocytopenia. This report describes the occurrence of thrombocytopenia in one chimpanzee and one rhesus monkey upon administration of potent FRAs. Chimpanz