Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Michael E Boulton"'
Autor:
Halesha D Basavarajappa, Rania S Sulaiman, Xiaoping Qi, Trupti Shetty, Sardar Sheik Pran Babu, Kamakshi L Sishtla, Bit Lee, Judith Quigley, Sameerah Alkhairy, Christian M Briggs, Kamna Gupta, Buyun Tang, Mehdi Shadmand, Maria B Grant, Michael E Boulton, Seung‐Yong Seo, Timothy W Corson
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 6, Pp 786-801 (2017)
Abstract Ocular neovascularization underlies major blinding eye diseases such as “wet” age‐related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and re
Externí odkaz:
https://doaj.org/article/3e824506a6224c1eb5ab5fcfef835898
Publikováno v:
Cells, Vol 9, Iss 4, p 905 (2020)
Retinal homeostasis is under both diurnal and circadian regulation. We sought to investigate the diurnal expression of autophagy proteins in normal rodent retina and to determine if this is impaired in diabetic retinopathy. C57BL/6J mice and Bio-Bree
Externí odkaz:
https://doaj.org/article/86a8d53e74f94669a9dc5c48e2ffd846
Autor:
Danielle McAnally, Khandaker Siddiquee, Ahmed Gomaa, Andras Szabo, Stefan Vasile, Patrick R Maloney, Daniela B Divlianska, Satyamaheshwar Peddibhotla, Camilo J Morfa, Paul Hershberger, Rebecca Falter, Robert Williamson, David B Terry, Rafal Farjo, Anthony B Pinkerton, Xiaping Qi, Judith Quigley, Michael E Boulton, Maria B Grant, Layton H Smith
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202436 (2018)
Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The loss of vision resulting from these diseases significantly im
Externí odkaz:
https://doaj.org/article/2711b08fb0d24cb796c83d996b6a93ad
Autor:
Chunjuan Song, Sayak K Mitter, Xiaoping Qi, Eleni Beli, Haripriya V Rao, Jindong Ding, Colin S Ip, Hongmei Gu, Debra Akin, William A Dunn, Catherine Bowes Rickman, Alfred S Lewin, Maria B Grant, Michael E Boulton
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171940 (2017)
p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene expression influencing cellular fate. We studied the effect of hydrogen per
Externí odkaz:
https://doaj.org/article/4bf9aaa6427c4582993782460d6aff9c
Autor:
Qi Wang, Maria Tikhonenko, Svetlana N Bozack, Todd A Lydic, Lily Yan, Nicholas L Panchy, Kelly M McSorley, Matthew S Faber, Yuanqing Yan, Michael E Boulton, Maria B Grant, Julia V Busik
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95028 (2014)
Disruption of circadian regulation was recently shown to cause diabetes and metabolic disease. We have previously demonstrated that retinal lipid metabolism contributed to the development of diabetic retinopathy. The goal of this study was to determi
Externí odkaz:
https://doaj.org/article/91ddcbacf2204ebfa6b8a2bfbcf29d83
Autor:
Yagna P R Jarajapu, Sugata Hazra, Mark Segal, Sergio Li Calzi, Chandra Jadhao, Kevin Qian, Sayak K Mitter, Mohan K Raizada, Michael E Boulton, Maria B Grant
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93965 (2014)
We hypothesized that endothelial progenitor cells derived from individuals with diabetes would exhibit functional defects including inability to respond to hypoxia and altered paracrine/autocrine function that would impair the angiogenic potential of
Externí odkaz:
https://doaj.org/article/e7f09b25d3ea4ccbb11862b45c54bae8
Autor:
Yuanqing Yan, Tatiana E Salazar, James M Dominguez, Dung V Nguyen, Sergio Li Calzi, Ashay D Bhatwadekar, Xiaoping Qi, Julia V Busik, Michael E Boulton, Maria B Grant
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80029 (2013)
Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and post-transcriptional level suggesting the role of microRNA (miRNA) and double-stranded RNA
Externí odkaz:
https://doaj.org/article/29a7c592192a4ca69cf86dab84bfe6a8
Autor:
Sugata Hazra, Valerie Stepps, Ashay D Bhatwadekar, Sergio Caballero, Michael E Boulton, Paul J Higgins, Elena V Nikonova, Carl J Pepine, Catherine Thut, Eva M Finney, David J Stone, Stephen H Bartelmez, Maria B Grant
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79067 (2013)
Previously, we showed that transient inhibition of TGF- β1 resulted in correction of key aspects of diabetes-induced CD34(+) cell dysfunction. In this report, we examine the effect of transient inhibition of plasminogen activator inhibitor-1 (PAI-1)
Externí odkaz:
https://doaj.org/article/46a5af6d5ea341dbaded9bbbcf0726cd
Autor:
Yagna P R Jarajapu, Jun Cai, Yuanqing Yan, Sergio Li Calzi, Jennifer L Kielczewski, Ping Hu, Lynn C Shaw, Sue M Firth, Tailoi Chan-Ling, Michael E Boulton, Robert C Baxter, Maria B Grant
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39398 (2012)
Previously, we showed that insulin growth factor (IGF)-1 binding protein-3 (IGFBP-3), independent of IGF-1, reduces pathological angiogenesis in a mouse model of the oxygen-induced retinopathy (OIR). The current study evaluates novel endothelium-depe
Externí odkaz:
https://doaj.org/article/a6bed053f9ec4607a3b13d296454f376
Autor:
Prajitha Thampi, Haripriya Vittal Rao, Sayak K Mitter, Jun Cai, Haoyu Mao, Hong Li, Soojung Seo, Xiaoping Qi, Alfred S Lewin, Carl Romano, Michael E Boulton
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34468 (2012)
Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration. The aim of this study was to determine if a 5-HT(1A) receptor agonist can reduce
Externí odkaz:
https://doaj.org/article/5356af4d834e41e9a9553c95e8ecd49d