Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Michael E Birnbaum"'
Autor:
Kim Bich Nguyen, Malte Roerden, Christopher J Copeland, Coralie M Backlund, Nory G Klop-Packel, Tanaka Remba, Byungji Kim, Nishant K Singh, Michael E Birnbaum, Darrell J Irvine, Stefani Spranger
Publikováno v:
eLife, Vol 12 (2023)
Cancer immunotherapies, in particular checkpoint blockade immunotherapy (CBT), can induce control of cancer growth, with a fraction of patients experiencing durable responses. However, the majority of patients currently do not respond to CBT and the
Externí odkaz:
https://doaj.org/article/9322e2334e694187a616ac7046594ee7
Publikováno v:
eLife, Vol 11 (2022)
T cells play a critical role in the adaptive immune response, recognizing peptide antigens presented on the cell surface by major histocompatibility complex (MHC) proteins. While assessing peptides for MHC binding is an important component of probing
Externí odkaz:
https://doaj.org/article/3b3a30405efb40ba9ede9aea6f8d86ee
Autor:
Ricardo A Fernandes, Chaoran Li, Gang Wang, Xinbo Yang, Christina S Savvides, Caleb R Glassman, Shen Dong, Eric Luxenberg, Leah V Sibener, Michael E Birnbaum, Christophe Benoist, Diane Mathis, K Christopher Garcia
Publikováno v:
eLife, Vol 9 (2020)
T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet the degree of peptide specificity of Treg-cell function, and whether Treg ligands can be u
Externí odkaz:
https://doaj.org/article/901b336084904a38bd5004c2630ed0ff
Autor:
M Patricia D'Souza, Erin Adams, John D Altman, Michael E Birnbaum, Cesar Boggiano, Giulia Casorati, Yueh-Hsiu Chien, Anthony Conley, Sidonia Barbara Guiomar Eckle, Klaus Früh, Timothy Gondré-Lewis, Namir Hassan, Huang Huang, Lakshmi Jayashankar, Anne G Kasmar, Nina Kunwar, Judith Lavelle, David M Lewinsohn, Branch Moody, Louis Picker, Lakshmi Ramachandra, Nilabh Shastri, Peter Parham, Andrew J McMichael, Jonathan W Yewdell
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007567 (2019)
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition
Externí odkaz:
https://doaj.org/article/cc3b6392d68c4db2b0fca2712a8da0c6
Autor:
Ri Lu, Yan Shan Ang, Ka‐Wai Cheung, Kai Yun Quek, Wei‐Xiang Sin, Elizabeth Lee, Shir Lynn Lim, Lin‐Yue Lanry Yung, Michael E. Birnbaum, Jongyoon Han, Lih Feng Cheow, Kerwin Kwek Zeming
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Cytokines, crucial in immune modulation, impact disease progression when their secretion is dysregulated. Existing methods for profiling cytokine secretion suffer from time‐consuming and labor‐intensive processes and often fail to captur
Externí odkaz:
https://doaj.org/article/667d895d7fe443dd9e156f2e8184a4d5
Autor:
Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mec
Externí odkaz:
https://doaj.org/article/6711e44bcbe14aeaa34f0e56893dd8c0
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Identifying peptides that can bind major histocompatibility complex II (MHC-II) is important for our understanding of T cell immunity and specificity. Here the authors present a yeast-display library screening approach that identifies more potential
Externí odkaz:
https://doaj.org/article/8de8cc1f22874ebb952282dd1b637f54
Autor:
Nathaniel D. Chu, Haixin Sarah Bi, Ryan O. Emerson, Anna M. Sherwood, Michael E. Birnbaum, Harlan S. Robins, Eric J. Alm
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell’s specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells
Externí odkaz:
https://doaj.org/article/ce0c5f9640c74c6d895963351a66b37d
Autor:
Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine E. Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann, Michael E. Birnbaum
Publikováno v:
Nature Biomedical Engineering. 7:599-602
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0302bc3469fd3927d325b8ba24a61439
https://doi.org/10.1038/s41551-023-01006-4
https://doi.org/10.1038/s41551-023-01006-4
Autor:
Hugo G. Hilton, Curtis P. McMurtrey, Alex S. Han, Zakia Djaoud, Lisbeth A. Guethlein, Jeroen H. Blokhuis, Jason L. Pugh, Ana Goyos, Amir Horowitz, Rico Buchli, Ken W. Jackson, Wilfred Bardet, David A. Bushnell, Philip J. Robinson, Juan L. Mendoza, Michael E. Birnbaum, Morten Nielsen, K. Christopher Garcia, William H. Hildebrand, Peter Parham
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1394-1405 (2017)
HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-co
Externí odkaz:
https://doaj.org/article/80996e0dab9f4ff09d46ee3a014674f3