Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Michael E Belloy"'
Autor:
Prashnna K. Gyawali, Yann Le Guen, Xiaoxia Liu, Michael E. Belloy, Hua Tang, James Zou, Zihuai He
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Risk prediction models using genetic data have seen increasing traction in genomics. However, most of the polygenic risk models were developed using data from participants with similar (mostly European) ancestry. This can lead to biases in t
Externí odkaz:
https://doaj.org/article/7ee2b42c6f4544aaaf46e766147b02dd
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Lewy body (LB) pathology commonly occurs in individuals with Alzheimer’s disease (AD) pathology. However, it remains unclear which genetic risk factors underlie AD pathology, LB pathology, or AD-LB co-pathology. Notably, whether APOE-ε4 a
Externí odkaz:
https://doaj.org/article/bc6442035bc14c9d8dfec27fe1270bdb
Autor:
Christina B. Young, Emily Johns, Gabriel Kennedy, Michael E. Belloy, Philip S. Insel, Michael D. Greicius, Reisa A. Sperling, Keith A. Johnson, Kathleen L. Poston, Elizabeth C. Mormino, for the Alzheimer’s Disease Neuroimaging Initiative, the A4 Study Team
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-14 (2023)
Abstract Background APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are reported in animal and human cell models. The degree to which these effects are present in humans
Externí odkaz:
https://doaj.org/article/3bee54045fa448f4900aab27548666cc
Autor:
Zihuai He, Linxi Liu, Michael E. Belloy, Yann Le Guen, Aaron Sossin, Xiaoxia Liu, Xinran Qi, Shiyang Ma, Prashnna K. Gyawali, Tony Wyss-Coray, Hua Tang, Chiara Sabatti, Emmanuel Candès, Michael D. Greicius, Iuliana Ionita-Laza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors present GhostKnockoff, a method for genome-wide association studies which can be applied to enhance existing and future studies to identify functional variants with weaker statistical effects that might be missed by conventional associati
Externí odkaz:
https://doaj.org/article/8a4affe73e044277a90ea1ba3e8812dc
Autor:
Michael E. Belloy, Sarah J. Eger, Yann Le Guen, Vincent Damotte, Shahzad Ahmad, M. Arfan Ikram, Alfredo Ramirez, Anthoula C. Tsolaki, Giacomina Rossi, Iris E. Jansen, Itziar de Rojas, Kayenat Parveen, Kristel Sleegers, Martin Ingelsson, Mikko Hiltunen, Najaf Amin, Ole Andreassen, Pascual Sánchez-Juan, Patrick Kehoe, Philippe Amouyel, Rebecca Sims, Ruth Frikke-Schmidt, Wiesje M. van der Flier, Jean-Charles Lambert, for the European Alzheimer & Dementia BioBank (EADB), Zihuai He, Summer S. Han, Valerio Napolioni, Michael D. Greicius
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance our understanding of
Externí odkaz:
https://doaj.org/article/5013e50361ee4e08a848d2a36da27e65
Autor:
Yann Le Guen, Michael E. Belloy, Valerio Napolioni, Sarah J. Eger, Gabriel Kennedy, Ran Tao, Zihuai He, Michael D. Greicius, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Many Alzheimer’s disease (AD) genetic association studies disregard age or incorrectly account for it, hampering variant discovery. Methods Using simulated data, we compared the statistical power of several models: logistic regr
Externí odkaz:
https://doaj.org/article/a7d9e5565a154945b4008bab5151178c
Publikováno v:
Nature Machine Intelligence. 4:761-771
Lewy body (LB) pathology commonly occurs in individuals with Alzheimer’s disease (AD) pathology. However, it remains unclear which genetic risk factors underlie AD pathology, LB pathology, or AD-LB co-pathology. Notably, whetherAPOE-ε4 affects ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0e4253846ade8fedea990aa4a6a82d0
https://doi.org/10.1101/2023.04.21.23288938
https://doi.org/10.1101/2023.04.21.23288938
Autor:
Robert R. Butler, Jarod Rutledge, Michael D. Greicius, Linxi Liu, Michael E. Belloy, Andrew C. Yang, Justin Lee, Frank M. Longo, Elizabeth C. Mormino, Iuliana Ionita-Laza, Shiyang Ma, Zihuai He, Xiaoxia Liu, Tony Wyss-Coray, Yann Le Guen, Hua Tang, Bowen Song, Patricia Moran Losada
Publikováno v:
American Journal of Human Genetics
Summary Knockoff-based methods have become increasingly popular due to their enhanced power for locus discovery and their ability to prioritize putative causal variants in a genome-wide analysis. However, because of the substantial computational cost
Autor:
Michael E Belloy, Yann Le Guen, Sarah J Eger, Valerio Napolioni, Zihuai He, Elizabeth C. Mormino, Michael D Greicius
Publikováno v:
Alzheimer's & Dementia. 18