Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael E Baumgartner"'
Autor:
Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001710 (2022)
Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different sugars. Here, we discov
Externí odkaz:
https://doaj.org/article/4566caa47f404199853ee3a3653a5ebf
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009946 (2021)
Cell competition induces the elimination of less-fit "loser" cells by fitter "winner" cells. In Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are outcompeted by wild-type cells. Rp/+ cells display proteotoxic stress
Externí odkaz:
https://doaj.org/article/ac2631e17d4d4aaf9cfc5e7644ff61ae
Autor:
Michael E. Baumgartner, Paul F. Langton, Remi Logeay, Alex Mastrogiannopoulos, Anna Nilsson-Takeuchi, Iwo Kucinski, Jules Lavalou, Eugenia Piddini
Investigating organ biology often requires methodologies to induce genetically distinct clones within a living tissue. However, the 3D nature of clones makes sample image analysis challenging and slow, limiting the amount of information that can be e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70835b1814e36c248d097a9bf30b39e1
https://www.repository.cam.ac.uk/handle/1810/349719
https://www.repository.cam.ac.uk/handle/1810/349719
Autor:
Linda S. Baumgartner, Michael E. Baumgartner, David Shook, Steven A. Messina, Michael D. Seidman, Ernest J. Moore, James E. Baumgartner
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 2, Pp 164-180 (2021)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
While cell therapies hold remarkable promise for replacing injured cells and repairing damaged tissues, cell replacement is not the only means by which these therapies can achieve therapeutic effect. For example, recent publications show that treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14aab5c4040a862f0d491a5c337f4a3
https://doaj.org/article/88a7c5b80e5c494e92c2d0876de391ac
https://doaj.org/article/88a7c5b80e5c494e92c2d0876de391ac
Publikováno v:
Baumgartner, M E, Dinan, M, Langton, P F, Kucinski, I & Piddini, E 2021, ' Proteotoxic stress is a driver of the loser status and of cell competition ', Nature Cell Biology, vol. 23, no. 2, pp. 136-146 . https://doi.org/10.1038/s41556-020-00627-0
Nature cell biology
Nature cell biology
Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell competition, cells with a heterozygous mutation in ribosome genes, such as RpS3+/− cells, are eliminated by wild-type cells. How cells are primed as l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb458178d927d282c6d93ad27ec58088
https://doi.org/10.1038/s41556-020-00627-0
https://doi.org/10.1038/s41556-020-00627-0
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 12, p e1009946 (2021)
Langton, P F, Baumgartner, M E, Logeay, R & Piddini, E 2021, ' Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status ', PLoS Genetics, vol. 17, no. 2, e1009946 . https://doi.org/10.1371/journal.pgen.1009946
PLoS Genetics, Vol 17, Iss 12, p e1009946 (2021)
Langton, P F, Baumgartner, M E, Logeay, R & Piddini, E 2021, ' Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status ', PLoS Genetics, vol. 17, no. 2, e1009946 . https://doi.org/10.1371/journal.pgen.1009946
Cell competition induces the elimination of less-fit “loser” cells by fitter “winner” cells. In Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are outcompeted by wild-type cells. Rp/+ cells display proteotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75f23f1653f3ceae2faa11158283fff
http://europepmc.org/articles/PMC8675655
http://europepmc.org/articles/PMC8675655
Investigating organ biology requires sophisticated methodologies to induce genetically distinct clones within a tissue. Microscopic analysis of such samples produces information-rich 3D images. However, the 3D nature and spatial anisotropy of clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2152e551140fd910fb86cbd7c61ecb76
https://doi.org/10.1101/2021.07.06.451317
https://doi.org/10.1101/2021.07.06.451317
Mutations in ribosome protein (Rp) genes and ribosome biogenesis factors result in debilitating diseases known as ribosomopathies. Recent studies in Drosophila have shown that cells heterozygous mutant for Rp genes (Rp/+) exhibit proteotoxic stress a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947dea018ce219fbbdd117c665e582e4
https://doi.org/10.1101/2021.05.10.443504
https://doi.org/10.1101/2021.05.10.443504
Publikováno v:
Developmental Cell. 56:2401-2402
Human induced pluripotent stem cells (hIPSCs) are an important tool, but challenges remain in optimizing their use. hIPSC cultures frequently become contaminated and overrun with cells containing genetic aberrations. In this issue of Developmental Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9194a285da594696b7ed76bafe028718
https://doi.org/10.1016/j.devcel.2021.08.011
https://doi.org/10.1016/j.devcel.2021.08.011
Autor:
James E. Baumgartner, Linda S. Baumgartner, Michael E. Baumgartner, Ernest J. Moore, Steven A. Messina, Michael D. Seidman, David R. Shook
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 2, Pp 164-180 (2021)
Abstract While cell therapies hold remarkable promise for replacing injured cells and repairing damaged tissues, cell replacement is not the only means by which these therapies can achieve therapeutic effect. For example, recent publications show tha
Externí odkaz:
https://doaj.org/article/88a7c5b80e5c494e92c2d0876de391ac