The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.

Autor: Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini

Publikováno v: PLoS Biology, Vol 20, Iss 7, p e3001710 (2022)

Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different sugars. Here, we discov

Externí odkaz: https://doaj.org/article/4566caa47f404199853ee3a3653a5ebf

Transorbital intraoperative electrocorticography-guided surgical resection for medically refractory developmental epileptic encephalopathy with spike-wave activation in sleep

Autor: Michael E. Baumgartner, Sudha Kessler, Alier J. Franco, Samuel B. Tomlinson, Benjamin C. Kennedy

Publikováno v: Epilepsy & Behavior Reports, Vol 28, Iss , Pp 100712- (2024)

Developmental epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS) is an epilepsy syndrome of childhood characterized by developmental delay or regression with significant abnormal epileptiform activity during sleep. In some cases,

Externí odkaz: https://doaj.org/article/abe171d8721849f482e2dddc1fc71806

Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss

Autor: Linda S. Baumgartner, Michael E. Baumgartner, David Shook, Steven A. Messina, Michael D. Seidman, Ernest J. Moore, James E. Baumgartner

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 2, Pp 164-180 (2021)
Stem Cells Translational Medicine

While cell therapies hold remarkable promise for replacing injured cells and repairing damaged tissues, cell replacement is not the only means by which these therapies can achieve therapeutic effect. For example, recent publications show that treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14aab5c4040a862f0d491a5c337f4a3
https://doaj.org/article/88a7c5b80e5c494e92c2d0876de391ac

Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status

Autor: Logeay R, Paul F. Langton, Michael E. Baumgartner, Eugenia Piddini

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 17, Iss 12, p e1009946 (2021)
Langton, P F, Baumgartner, M E, Logeay, R & Piddini, E 2021, ' Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status ', PLoS Genetics, vol. 17, no. 2, e1009946 . https://doi.org/10.1371/journal.pgen.1009946

Cell competition induces the elimination of less-fit “loser” cells by fitter “winner” cells. In Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are outcompeted by wild-type cells. Rp/+ cells display proteotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75f23f1653f3ceae2faa11158283fff
http://europepmc.org/articles/PMC8675655

Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in Drosophila

Autor: Michael E. Baumgartner, Eugenia Piddini, Iwo Kucinski

Mutations in ribosome protein (Rp) genes and ribosome biogenesis factors result in debilitating diseases known as ribosomopathies. Recent studies in Drosophila have shown that cells heterozygous mutant for Rp genes (Rp/+) exhibit proteotoxic stress a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::947dea018ce219fbbdd117c665e582e4
https://doi.org/10.1101/2021.05.10.443504