Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Michael E, Ward"'
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-5 (2024)
Abstract This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/a36e0957494842178bf60c68ee7aa96b
Autor:
Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)
Abstract Background Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis. Over 70 mutations discovered in the GRN gene all result in redu
Externí odkaz:
https://doaj.org/article/ae3e17116c4b4fa5a12ef111d84e132a
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/9628565cd0fc43dc81e3535e124ec483
Autor:
Makayla Portley, Carolyn Sherer, Tianxia Wu, Jennifer Farren, Laura E. Danielian, Sonja W. Scholz, Bryan J. Traynor, Michael E. Ward, Taryn Haselhuhn, Allison Snyder, Justin Y. Kwan
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1816-1823 (2023)
Abstract Objective Cognitive contributions to decisional capacity are complex and not well understood. Capacity to consent for research has been linked to executive function, but executive function assessment tools are imperfect. In this study, we ex
Externí odkaz:
https://doaj.org/article/ada1ac69360548858b23f77a82cc0ee4
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 proteinopathy spans a spectrum of incurable, heterogeneous, and in
Externí odkaz:
https://doaj.org/article/c2741b5e80194d549e3f338eb6ddeb60
Autor:
Luke Reilly, Erika Lara, Daniel Ramos, Ziyi Li, Caroline B. Pantazis, Julia Stadler, Marianita Santiana, Jessica Roberts, Faraz Faghri, Ying Hao, Mike A. Nalls, Priyanka Narayan, Yansheng Liu, Andrew B. Singleton, Mark R. Cookson, Michael E. Ward, Yue A. Qi
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 10, Pp 100593- (2023)
Summary: Here, we present a standardized, “off-the-shelf” proteomics pipeline working in a single 96-well plate to achieve deep coverage of cellular proteomes with high throughput and scalability. This integrated pipeline streamlines a fully auto
Externí odkaz:
https://doaj.org/article/70e5f58e885a4fae9da3862e8bf66e4e
Autor:
Sarah Pickles, Desiree Zanetti Alepuz, Yuka Koike, Mei Yue, Jimei Tong, Pinghu Liu, Yugui Zhou, Karen Jansen-West, Lillian M. Daughrity, Yuping Song, Michael DeTure, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, Keith A. Josephs, Dennis W. Dickson, Michael E. Ward, Lijin Dong, Mercedes Prudencio, Casey N. Cook, Leonard Petrucelli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Treatments for neurodegenerative disease, including Frontotemporal dementia (FTD) and Amyotrophic lateral sclerosis (ALS), remain rather limited, underscoring the need for greater mechanistic insight and disease-relevant models. Our ability to develo
Externí odkaz:
https://doaj.org/article/f5770006374045b4827be986a2b16eba
Autor:
Anant Dadu, Vipul K. Satone, Rachneet Kaur, Mathew J. Koretsky, Hirotaka Iwaki, Yue A. Qi, Daniel M. Ramos, Brian Avants, Jacob Hesterman, Roger Gunn, Mark R. Cookson, Michael E. Ward, Andrew B. Singleton, Roy H. Campbell, Mike A. Nalls, Faraz Faghri
Publikováno v:
Patterns, Vol 4, Iss 6, Pp 100741- (2023)
Summary: High-dimensional data analysis starts with projecting the data to low dimensions to visualize and understand the underlying data structure. Several methods have been developed for dimensionality reduction, but they are limited to cross-secti
Externí odkaz:
https://doaj.org/article/ad52d417db9a4335834e045b65448695
Autor:
Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/10b8a1553d0b4966a9c5ea4d64af7dbf
Autor:
Luke Reilly, Sahba Seddighi, Andrew B. Singleton, Mark R. Cookson, Michael E. Ward, Yue A. Qi
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Genomic diversity plays critical roles in risk of disease pathogenesis and diagnosis. While genomic variants—including single nucleotide variants, frameshift variants, and mis-splicing isoforms—are commonly detected at the DNA or RNA level, their
Externí odkaz:
https://doaj.org/article/aa745b1b5cc54c349283834da0335576