Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Michael E, Selzer"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of chondroitin sulfate proteoglycans (CSPGs) at the site of injury with chondroitinase ABC (ChABC), each can reduce retrograde neurona
Externí odkaz:
https://doaj.org/article/8ab27c06e866439facea1a3d62b1114a
Autor:
Nune Darbinian, Armine Darbinyan, Nana Merabova, Myrna Kassem, Gabriel Tatevosian, Shohreh Amini, Laura Goetzl, Michael E. Selzer
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionMitochondrial dysfunction is postulated to be a central event in fetal alcohol spectrum disorders (FASD). People with the most severe form of FASD, fetal alcohol syndrome (FAS) are estimated to live only 34 years (95% confidence interval,
Externí odkaz:
https://doaj.org/article/cd581b5194c84af399acf8a6b6b3268a
Autor:
Nune Darbinian, Michael E Selzer
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 3, Pp 497-502 (2022)
The pathology of fetal alcohol syndrome and the less severe fetal alcohol spectrum disorders includes brain dysmyelination. Recent studies have shed light on the molecular mechanisms underlying these white matter abnormalities. Rodent models of fetal
Externí odkaz:
https://doaj.org/article/d8b5fe7afcd846d6bb6d7f7605fe8c77
Autor:
Guixin Zhang, Li-Qing Jin, William Rodemer, Jianli Hu, Zachary D. Root, Daniel M. Medeiros, Michael E. Selzer
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Axon regrowth after spinal cord injury (SCI) is inhibited by several types of inhibitory extracellular molecules in the central nervous system (CNS), including chondroitin sulfate proteoglycans (CSPGs), which also are components of perineuronal nets
Externí odkaz:
https://doaj.org/article/9c41ccef149447e59f41956a4bce1fc4
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 6, Pp 996-1005 (2020)
Some neurons, especially in mammalian peripheral nervous system or in lower vertebrate or in vertebrate central nervous system (CNS) regenerate after axotomy, while most mammalian CNS neurons fail to regenerate. There is an emerging consensus that ne
Externí odkaz:
https://doaj.org/article/d059ea2e629c4b3eb8c956d9b8233626
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 9, Pp 1955-1956 (2022)
Externí odkaz:
https://doaj.org/article/cc37e70756734695ae6545ad34df4ffb
Autor:
William Rodemer, Michael E. Selzer
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 3, Pp 399-404 (2019)
Spinal cord injury leads to persistent behavioral deficits because mammalian central nervous system axons fail to regenerate. A neuron’s response to axon injury results from a complex interplay of neuron-intrinsic and environmental factors. The con
Externí odkaz:
https://doaj.org/article/11e3a83dde644baeb37521fb66315612
Publikováno v:
Cells, Vol 11, Iss 15, p 2320 (2022)
Axotomy in the CNS activates retrograde signals that can trigger regeneration or cell death. Whether these outcomes use different injury signals is not known. Local protein synthesis in axon tips plays an important role in axon retraction and regener
Externí odkaz:
https://doaj.org/article/6a3ce620adfc4bd9a9a73cbff0a1f09c
The spinal cord is a vital part of the central nervous system; even a small injury can lead to severe disability. In the US, there are approximately 230,000 people living with traumatic spinal cord injury (SCI), with over 10,000 more becoming disable
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is believed that axon growth is inhibited by the presence of several types of inhibitory molecules in central nervous system (CNS), including the chondroitin su
Externí odkaz:
https://doaj.org/article/8c8a9bb4d8d748278aa0c91a80131f15