Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Michael Duckworth"'
Autor:
Angela L. Bosma, Louise A. A. Gerbens, Hajar El Khattabi, Floris C. Loeff, Michael Duckworth, Richard T. Woolf, Theo Rispens, Catherine H. Smith, Phyllis I. Spuls
Publikováno v:
Journal of Dermatological Treatment, Vol 34, Iss 1 (2023)
Background Dupilumab is prescribed in one dosage across adult atopic dermatitis patients. Differences in drug exposure may explain variation in treatment response. Objective Investigating the clinical relevance of dupilumab serum concentration in ato
Externí odkaz:
https://doaj.org/article/a39c861adb6940adad969c18ee931271
Autor:
Teresa Tsakok, Jake Saklatvala, Theo Rispens, Floris C. Loeff, Annick de Vries, Michael H. Allen, Ines A. Barbosa, David Baudry, Tejus Dasandi, Michael Duckworth, Freya Meynell, Alice Russell, Anna Chapman, Sandy McBride, Kevin McKenna, Gayathri Perera, Helen Ramsay, Raakhee Ramesh, Kathleen Sands, Alexa Shipman, the Biomarkers of Systemic Treatment Outcomes in Psoriasis (BSTOP) Study Group, A. David Burden, Christopher E.M. Griffiths, Nick J. Reynolds, Richard B. Warren, Satveer Mahil, Jonathan Barker, Nick Dand, Catherine Smith, Michael A. Simpson
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Targeted biologic therapies can elicit an undesirable host immune response characterized by the development of antidrug antibodies (ADA), an important cause of treatment failure. The most widely used biologic across immune-mediated diseases is adalim
Externí odkaz:
https://doaj.org/article/b7bce9e049e346049f02cc279904382b
Autor:
Shan Pan, Teresa Tsakok, Nick Dand, Dagan O. Lonsdale, Floris C. Loeff, Karien Bloem, Annick deVries, David Baudry, Michael Duckworth, Satveer Mahil, Angela Pushpa‐Rajah, Alice Russell, Ali Alsharqi, Gabrielle Becher, Ruth Murphy, Shyamal Wahie, Andrew Wright, Christopher E.M. Griffiths, Nick J. Reynolds, Jonathan Barker, Richard B. Warren, A. David Burden, Theo Rispens, Joseph F. Standing, Catherine H. Smith, on behalf of the BADBIR Study Group, the BSTOP Study Group, the PSORT Consortium
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 400-409 (2020)
Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real‐world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first‐l
Externí odkaz:
https://doaj.org/article/619cb5f9e3a54af0aff4b70a0b891c13
Autor:
Christos Petridis, Alexander A. Navarini, Nick Dand, Jake Saklatvala, David Baudry, Michael Duckworth, Michael H. Allen, Charles J. Curtis, Sang Hyuck Lee, A. David Burden, Alison Layton, Veronique Bataille, Andrew E. Pink, The Acne Genetic Study Group, Isabelle Carlavan, Johannes J. Voegel, Timothy D. Spector, Richard C. Trembath, John A. McGrath, Catherine H. Smith, Jonathan N. Barker, Michael A. Simpson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure a
Externí odkaz:
https://doaj.org/article/452ea8192e3a4a489db21942afed2d37
Autor:
Mehreen, Soomro, Michael, Stadler, Nick, Dand, James, Bluett, Deepak, Jadon, Farideh, Jalali-Najafabadi, Michael, Duckworth, Pauline, Ho, Helena, Marzo-Ortega, Philip S, Helliwell, Anthony W, Ryan, David, Kane, Eleanor, Korendowych, Michael A, Simpson, Jonathan, Packham, Ross, McManus, Cem, Gabay, Céline, Lamacchia, Michael J, Nissen, Matthew A, Brown, Suzanne M M, Verstappen, Tjeerd, Van Staa, Jonathan N, Barker, Catherine H, Smith, Oliver, FitzGerald, Neil, McHugh, Richard B, Warren, John, Bowes
Publikováno v:
2022, ' Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling ', Arthritis and Rheumatology, vol. 74, no. 9, pp. 1535-1543 . https://doi.org/10.1002/art.42154
BADBIR Study Group 2022, ' Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling ', Arthritis & rheumatology (Hoboken, N.J.), vol. 74, no. 9, pp. 1535-1543 . https://doi.org/10.1002/art.42154
BADBIR Study Group 2022, ' Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling ', Arthritis & rheumatology (Hoboken, N.J.), vol. 74, no. 9, pp. 1535-1543 . https://doi.org/10.1002/art.42154
Objectives: Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e08610b06d2af5be81cd231f214933
https://kclpure.kcl.ac.uk/ws/files/180291144/Comparative_Genetic_Analysis_SOOMRO_Publishedonline4August2022_GOLD_VoR_CC_BY.pdf
https://kclpure.kcl.ac.uk/ws/files/180291144/Comparative_Genetic_Analysis_SOOMRO_Publishedonline4August2022_GOLD_VoR_CC_BY.pdf
Autor:
Floris C. Loeff, Teresa Tsakok, Lisanne Dijk, Margreet H. Hart, Michael Duckworth, David Baudry, Alice Russell, Nick Dand, Astrid van Leeuwen, Christopher E.M. Griffiths, Nick J. Reynolds, Jonathan Barker, A. David Burden, Richard B. Warren, Annick de Vries, Karien Bloem, Gerrit Jan Wolbink, Catherine H. Smith, Theo Rispens, Marilyn Benham, David Burden, Ian Evans, Christopher Griffiths, Sagair Hussain, Brian Kirby, Linda Lawson, Kayleigh Mason, Kathleen McElhone, Ruth Murphy, Anthony Ormerod, Caroline Owen, Nick Reynolds, Catherine Smith, Richard Warren, Jonathan N.W.N. Barker, Michael R. Barnes, Paola DiMeglio, Richard Emsley, Andrea Evans, Katherine Payne, Deborah Stocken
Publikováno v:
Journal of investigative dermatology, 140(11), 2129-2137. Nature Publishing Group
Ustekinumab is an effective treatment for psoriasis, but response varies between patients. The formation of anti-drug antibodies (ADAs) may explain part of this variation by reducing the free ustekinumab level. Currently, published analyses of the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af72e35776e92a9a9fda65c78d52a768
https://doi.org/10.1016/j.jid.2020.03.957
https://doi.org/10.1016/j.jid.2020.03.957
Publikováno v:
Journal of Investigative Dermatology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::76d7eb1292b3fbc6259e0dd5a163c359
Autor:
Eric E. Small, Michael Duckworth, Jared Creason, Jeremy Martinich, Michael Kolian, Heather Hosterman, Justin Stein, Matthew Rissing, David Mills, Cameron Wobus, Roger Jones, Ronald Hall
Publikováno v:
Global Environmental Change. 45:1-14
We use a physically-based water and energy balance model to simulate natural snow accumulation at 247 winter recreation locations across the continental United States. We combine this model with projections of snowmaking conditions to determine downh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691883c75446a93486c3b6699938c5ba
https://doi.org/10.1016/j.gloenvcha.2017.04.006
https://doi.org/10.1016/j.gloenvcha.2017.04.006
Autor:
Richard B. Warren, Christopher E.M. Griffiths, Karien Bloem, Jonathan Barker, Michael Duckworth, Teresa Tsakok, Ruth Murphy, Annick de Vries, Nina Wilson, Nick Dand, Joseph F. Standing, Floris C. Loeff, David Baudry, A. David Burden, Angela Pushpa-Rajah, Ali Alsharqi, Gabrielle Becher, Shan Pan, Theo Rispens, Shyamal Wahie, Andrew Wright, Catherine H. Smith, Nick J. Reynolds, Deborah D. Stocken
Publikováno v:
Tsakok, T, Wilson, N, Dand, N, Loeff, F C, Bloem, K, Baudry, D, Duckworth, M, Pan, S, Pushpa-Rajah, A, Standing, J F, De Vries, A, Alsharqi, A, Becher, G, Murphy, R, Wahie, S, Wright, A, Griffiths, C E M, Reynolds, N J, Barker, J, Warren, R B, Burden, A D, Rispens, T, Stocken, D & Smith, C 2019, ' Association of Serum Ustekinumab Levels with Clinical Response in Psoriasis ', JAMA dermatology, vol. 155, no. 11, pp. 1235-1243 . https://doi.org/10.1001/jamadermatol.2019.1783
JAMA dermatology, 155(11), 1235-1243. American Medical Association
JAMA dermatology, 155(11), 1235-1243. American Medical Association
Importance: High-cost biologic therapies have transformed the management of immune-mediated inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by measurement of circulating drug levels has been shown to be effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451b0b9087bd487c99f338161d735059
https://pubmed.ncbi.nlm.nih.gov/31532460
https://pubmed.ncbi.nlm.nih.gov/31532460
Autor:
Ewa Kloczko, Catherine H. Smith, Heather F Porter, Sarah Natas, Rosa Miquel, Alice Cotton, Jonathan Barker, Martin Crook, Kate Thornberry, Michael Duckworth, Terry Wong, Cathryn M. Lewis, Tracy Dew, Catriona Maybury
Publikováno v:
JAMA Dermatol
Importance Advanced liver fibrosis is a precursor to cirrhosis, a leading cause of mortality. People with severe psoriasis are at risk for liver disease, but our understanding of advanced fibrosis in individuals with psoriasis is limited. Objectives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3d1178f12790fbf50d6172b95ac59c
https://pubmed.ncbi.nlm.nih.gov/31166567
https://pubmed.ncbi.nlm.nih.gov/31166567