Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael Dragunow"'
Autor:
Florian Ermini, Victoria F. Low, Jennifer J. Song, Adelie Y. S. Tan, Richard L. M. Faull, Michael Dragunow, Maurice A. Curtis, Stephen S. Dominy
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-negative bacterium best known for its role in chronic periodontitis. Gingipains were recently identified in the middle temporal gyrus of postmortem Alzhei
Externí odkaz:
https://doaj.org/article/e8b7aafa120347438648a23f9c4049de
Autor:
James A. Wiseman, Helen C. Murray, Richard L. M. F. Faull, Michael Dragunow, Clinton P. Turner, Birger Victor Dieriks, Maurice A. Curtis
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract In Parkinson’s disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates form a myriad of conformational and truncational variants. Most antibodies used to detect and quantify α-Syn in the human brain target epitopes
Externí odkaz:
https://doaj.org/article/bfdc8b86e92a4efbb9294b4b59a33ad1
Autor:
Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis, Michael Dragunow
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the human brain, how
Externí odkaz:
https://doaj.org/article/0a4e76a833d74d76a95832207eacbaf4
Autor:
Zoe Woolf, Taylor J. Stevenson, Kevin Lee, Yewon Jung, Thomas I.H. Park, Maurice A. Curtis, Johanna M. Montgomery, Michael Dragunow
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100518- (2021)
Summary: Microglia are the primary innate immune effectors of the central nervous system. Although numerous protocols have been developed to isolate fetal mouse microglia, the isolation of adult mouse microglia has proven more difficult. Here, we pre
Externí odkaz:
https://doaj.org/article/b68aa760608a48cb8f36452dcfa3d647
Autor:
Beatriz Calvo-Flores Guzmán, Tessa Elizabeth Chaffey, Thulani Hansika Palpagama, Sarah Waters, Jordi Boix, Warren Perry Tate, Katie Peppercorn, Michael Dragunow, Henry John Waldvogel, Richard Lewis Maxwell Faull, Andrea Kwakowsky
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Alzheimer’s disease (AD), the most common chronic neurodegenerative disorder, has complex neuropathology. The principal neuropathological hallmarks of the disease are the deposition of extracellular β-amyloid (Aβ) plaques and neurofibrillary tang
Externí odkaz:
https://doaj.org/article/73d38b3f4b254478aa8c587a8d233baa
Autor:
Clinton P. Turner, Jessica McLay, Ian F. Hermans, Jason Correia, Arnold Bok, Nasim Mehrabi, Stephen Gock, Blake Highet, Maurice A. Curtis, Michael Dragunow
Publikováno v:
Pathology. 54:417-424
Tumour infiltrating lymphocyte (TIL) density is prognostically significant in various tumours, but few studies have investigated its significance in meningioma. This study aimed to investigate how TIL density differs by meningioma histology and wheth
Autor:
Samuel Rosset, Yi-Han Wu, Sahan Jayatissa, Thomas Park, Michael Dragunow, Iain A. Anderson, Vickie Shim
Publikováno v:
Electroactive Polymer Actuators and Devices (EAPAD) XXIV.
Autor:
Zoe Woolf, Molly Swanson, Amy Smith, Emma Scotter, Patrick Schweder, Edward Mee, Richard Faull, Michael Dragunow, Thomas Park
Publikováno v:
WFNOS 2022 Abstract Book.
Autor:
Susan YS Li, Rebecca Johnson, Patrick Schweder, Jason Correia, Thomas I-H Park, Michael Dragunow
Publikováno v:
WFNOS 2022 Abstract Book.
Publikováno v:
Journal of neurochemistry. 82(2)
This study describes the effect of signalling through muscarinic acetylcholine receptors on two transcription factors implicated in long-term synaptic plasticity and memory formation, EGR1 and the cyclic AMP response element binding protein (CREB). I