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Autor:
Michael Dr Oettel, A. Barth, Birgitt Schneider, J. Züchner, K. Müller, Gudrun Reddersen, Sigfrid Prof-Dr Schwarz, W. Elger, Annemarie Hedden, P. Ritter, E. Krahl
Publikováno v:
Reproduction, Fertility and Development. 13:297
Sulfamate substitution (-O-SO 2-NH 2) at carbon atom 3 of the steroid skeleton leads to orally active prodrugs of estrogens with much higher systemic, but lower hepatic, estrogenic activity than their parent steroids. This dissociation is achieved by