Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Michael Downes"'
Autor:
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetyla
Externí odkaz:
https://doaj.org/article/7cb7b07e6adf42b0aac1cff0935b9ca2
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Ting Fu, Tao Huan, Gibraan Rahman, Hui Zhi, Zhenjiang Xu, Tae Gyu Oh, Jian Guo, Sally Coulter, Anupriya Tripathi, Cameron Martino, Justin L. McCarville, Qiyun Zhu, Fritz Cayabyab, Brian Low, Mingxiao He, Shipei Xing, Fernando Vargas, Ruth T. Yu, Annette Atkins, Christopher Liddle, Janelle Ayres, Manuela Raffatellu, Pieter C. Dorrestein, Michael Downes, Rob Knight, Ronald M. Evans
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112997- (2023)
Summary: Colorectal cancer (CRC) is driven by genomic alterations in concert with dietary influences, with the gut microbiome implicated as an effector in disease development and progression. While meta-analyses have provided mechanistic insight into
Externí odkaz:
https://doaj.org/article/958122a9c5d843b58513ee7535fcecb3
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0290963 (2023)
BackgroundNew onset atrial fibrillation (NOAF) is the most common arrhythmia affecting critically ill patients with sepsis. NOAF is associated with increased intensive care unit mortality, increased hospital mortality, development of heart failure an
Externí odkaz:
https://doaj.org/article/4ed0bd52bc4442ee8418957caa3c7cc4
Autor:
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pål O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101504- (2022)
Objective: Exercise is a critical component of a healthy lifestyle and a key strategy for the prevention and management of metabolic disease. Identifying molecular mechanisms underlying adaptation in response to chronic physical activity is of critic
Externí odkaz:
https://doaj.org/article/855b431c342f44e185149aa1a1055a2d
Publikováno v:
Nutrients, Vol 15, Iss 8, p 1997 (2023)
Over the last decades, epidemiology and functional studies have started to reveal a pivotal role of vitamin D in both type 1 and type 2 diabetes pathogenesis. Acting through the vitamin D receptor (VDR), vitamin D regulates insulin secretion in pancr
Externí odkaz:
https://doaj.org/article/a8199c60db0e4fbe93067694556807b4
Autor:
Rongrong Zhou, Cristina Llorente, Jinling Cao, Livia S. Zaramela, Suling Zeng, Bei Gao, Shang-Zhen Li, Ryan D. Welch, Feng-Qing Huang, Lian-Wen Qi, Chuyue Pan, Yan Huang, Pengchen Zhou, Iris Beussen, Ying Zhang, Gregory Bryam, Oliver Fiehn, Lirui Wang, E-Hu Liu, Ruth T. Yu, Michael Downes, Ronald M. Evans, Karrie Goglin, Derrick E. Fouts, David A. Brenner, Lars Bode, Xuegong Fan, Karsten Zengler, Bernd Schnabl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 293-320 (2021)
Background & Aims: Fucosyltransferase 2 (Fut2)-mediated intestinal α1- 2-fucosylation is important for host–microbe interactions and has been associated with several diseases, but its role in obesity and hepatic steatohepatitis is not known. The a
Externí odkaz:
https://doaj.org/article/5af44eddfde74e05a6ad638356662629
Autor:
Joseph M. Valentine, Maryam Ahmadian, Omer Keinan, Mohammad Abu-Odeh, Peng Zhao, Xin Zhou, Mark P. Keller, Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, Alan R. Saltiel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized, catecholamine resistance remains largely unexplored. Murine β3-adrenergic receptor expression i
Externí odkaz:
https://doaj.org/article/b1dd70c4674a48e3a86163d957e18958
Autor:
Mohammad Abu-Odeh, Yuan Zhang, Shannon M. Reilly, Nima Ebadat, Omer Keinan, Joseph M. Valentine, Maziar Hafezi-Bakhtiari, Hadeel Ashayer, Lana Mamoun, Xin Zhou, Jin Zhang, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Steven A. Kliewer, David J. Mangelsdorf, Alan R. Saltiel
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109331- (2021)
Summary: The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF
Externí odkaz:
https://doaj.org/article/a3dccec6a5904a4aa8041367d94a1df1
Autor:
M. Charlotte Hemmer, Michael Wierer, Kristina Schachtrup, Michael Downes, Norbert Hübner, Ronald M. Evans, N. Henriette Uhlenhaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver,
Externí odkaz:
https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e