Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Michael Dosch"'
Autor:
Geoffrey Paltser, Xue Jun Liu, Jason Yantha, Shawn Winer, Hubert Tsui, Ping Wu, Yuko Maezawa, Lindsay S. Cahill, Christine L. Laliberté, Sreeram V. Ramagopalan, Gabriele C. DeLuca, A. Dessa Sadovnick, Igor Astsaturov, George C. Ebers, R. Mark Henkelman, Michael W. Salter, H.-Michael Dosch
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 149-159 (2013)
Abstract Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic needs are unmet, and whose pathoetiology is elusive. We report that transient receptor potential vanilloid-1 (TRPV1) expressed in a major sensory neu
Externí odkaz:
https://doaj.org/article/e5890ad622bf4df7ba2d1d634ebcb2de
Autor:
David, Hadley, Roy K, Cheung, Dorothy J, Becker, Rose, Girgis, Jerry P, Palmer, David, Cuthbertson, Jeffrey P, Krischer, Hans-Michael, Dosch, H-M, Dosch
Publikováno v:
Clinical and Vaccine Immunology. 21:203-211
Broad consensus assigns T lymphocytes fundamental roles in inflammatory, infectious, and autoimmune diseases. However, clinical investigations have lacked fully characterized and validated procedures, equivalent to those of widely practiced biochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b2b2697310a5cad606ab66e2416989
https://doi.org/10.1128/cvi.00516-13
https://doi.org/10.1128/cvi.00516-13
Autor:
Kevan C. Herold, Zhugong Liu, Paula McGee, John M. Lachin, Kasia Bourcier, Heidi Krause-Steinrauf, Mark D. Pescovitz, H.-Michael Dosch, Lisa M. Spain, Adam Asare
Publikováno v:
The Journal of Immunology. 187:1998-2005
Type 1 diabetes mellitus is believed to be due to the autoimmune destruction of β-cells by T lymphocytes, but a single course of rituximab, a monoclonal anti-CD20 B lymphocyte Ab, can attenuate C-peptide loss over the first year of disease. The effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9a058ea104ec0dcf0264bcf3ede906
https://doi.org/10.4049/jimmunol.1100539
https://doi.org/10.4049/jimmunol.1100539
Autor:
Mikael, Knip, Suvi M, Virtanen, Karri, Seppä, Jorma, Ilonen, Erkki, Savilahti, Outi, Vaarala, Antti, Reunanen, Kari, Teramo, Anu-Maaria, Hämäläinen, Johanna, Paronen, Hans-Michael, Dosch, Timo, Hakulinen, Hans K, Akerblom, S M, Virtanen
Publikováno v:
New England Journal of Medicine. 363:1900-1908
Early exposure to complex dietary proteins may increase the risk of beta-cell autoimmunity and type 1 diabetes in children with genetic susceptibility. We tested the hypothesis that supplementing breast milk with highly hydrolyzed milk formula would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e796b9ac0d577e2acab375fb408223a0
https://doi.org/10.1056/nejmoa1004809
https://doi.org/10.1056/nejmoa1004809
Autor:
Ping Wu, H.-Michael Dosch, Jason Yantha, Hubert Tsui, Geoff Paltser, Shawn Winer, Aihua Song, James Ellis
Publikováno v:
Diabetes
OBJECTIVE Autoimmune target tissues in type 1 diabetes include pancreatic β-cells and peri-islet Schwann cells (pSC)—the latter active participants or passive bystanders in pre-diabetic autoimmune progression. To distinguish between these alternat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5f8f68b63d25b44d7d4d4d01753fbb
https://doi.org/10.2337/db09-1209
https://doi.org/10.2337/db09-1209
Autor:
Benigno J. Digon, Lisa M. Spain, David M. Harlan, Michael Ring, Kristina I. Rother, Jerry P. Palmer, H.-Michael Dosch, Kim Chen, Patric Nelson, Robert Wesley, Barbara Brooks-Worrell, Alain D. Baron
Publikováno v:
Diabetes Care
OBJECTIVE In patients with long-standing type 1 diabetes, we investigated whether improved β-cell function can be achieved by combining intensive insulin therapy with agents that may 1) promote β-cell growth and/or limit β-cell apoptosis and 2) we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672ca995665c24c32f205e9c5375eee5
https://doi.org/10.2337/dc09-0773
https://doi.org/10.2337/dc09-0773
Autor:
Clinton J. Thompson, Lisa M. Spain, Barbara Brooks-Worrell, Peter A. Gottlieb, Kevan C. Herold, Helena Reijonen, Sefina Arif, John M. Lachin, Mark Peakman, Jerry Palmer, H.-Michael Dosch
Publikováno v:
Diabetes
OBJECTIVE Type 1 diabetes results from an immunemediated destruction of β-cells, likely to be mediated by T lymphocytes, but the sensitivity, specificity, and other measures of validity of existing assays for islet autoreactive T-cells are not well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5ce6aa49684db2de55a267f33462a4
https://doi.org/10.2337/db09-0249
https://doi.org/10.2337/db09-0249
Autor:
Julian Zielenski, Geoffrey Paltser, H.-Michael Dosch, Shawn Winer, Ruslan Dorfman, Edgar G. Engleman, Yongqian Wang, Yuko Maezawa, Fabrizio G. Mastronardi, Jasmine Bahrami, Daniel A. Winer, Dorothy Truong, Hubert Tsui, Yin Chan, Daniel J. Drucker
Publikováno v:
Nature Medicine. 15:921-929
Obesity and its associated metabolic syndromes represent a growing global challenge, yet mechanistic understanding of this pathology and current therapeutics are unsatisfactory. We discovered that CD4(+) T lymphocytes, resident in visceral adipose ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2866598a523290c3a6328b7f412756c7
https://doi.org/10.1038/nm.2001
https://doi.org/10.1038/nm.2001
Autor:
Shawn Winer, Jason Yantha, Geoffrey Paltser, Hubert Tsui, Lan Tang, Yin Chan, Dorothy Truong, Hans-Michael Dosch
Publikováno v:
Annals of the New York Academy of Sciences. 1150:32-42
Type 1 diabetes (T1D) is caused by autoimmune beta cell destruction. The early events triggering T1D and the forces that keep diabetic autoimmunity pancreas specific have been unclear. Our discovery that autoimmune islet destruction is not beta-cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6276e56d6acb8db7add6aab7561b4b9
https://doi.org/10.1196/annals.1447.033
https://doi.org/10.1196/annals.1447.033
Autor:
Shawn Winer, Dorothy J. Becker, James Ellis, Lan Tang, Hans-Michael Dosch, Roy K. Cheung, Thirumahal Selvanantham, Alisha R. Elford, Hubert Tsui, Pamela S. Ohashi, Yin Chan, Geoffrey Paltser
Publikováno v:
ResearcherID
OBJECTIVE— Type 1 diabetes reflects autoimmune destruction of β-cells and peri-islet Schwann cells (pSCs), but the mechanisms of pSC death and the T-cell epitopes involved remain unclear.RESEARCH DESIGN AND METHODS— Primary pSC cultures were gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd819ea7d63943df95c7c90685d5a92e
https://doi.org/10.2337/db07-0226
https://doi.org/10.2337/db07-0226