Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Michael Didonato"'
Autor:
Yaiza Diaz-de-Durana, Janet Lau, Deborah Knee, Christophe Filippi, Marco Londei, Peter McNamara, Marc Nasoff, Michael DiDonato, Richard Glynne, Ann E Herman
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78483 (2013)
Type-1 diabetes (T1D) is an autoimmune disease targeting insulin-producing beta cells, resulting in dependence on exogenous insulin. To date, significant efforts have been invested to develop immune-modulatory therapies for T1D treatment. Previously,
Externí odkaz:
https://doaj.org/article/0d4ffcfeb55d4b96aa7d0dfeaed2ab4b
Autor:
Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia
Non–small cell lung cancer patients carrying oncogenic EGFR mutations initially respond to EGFR-targeted therapy, but later elicit minimal response due to dose-limiting toxicities and acquired resistance. EGF816 is a novel, irreversible mutant-sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a47ea8c9761b6ff65861719c006cd7e
https://doi.org/10.1158/0008-5472.c.6507771.v1
https://doi.org/10.1158/0008-5472.c.6507771.v1
Autor:
Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia
This file contains the supplementary Table S1 that describes the characteristics and anti-proliferative activities of EGF816 on a number of patient-derived cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b02199c09204ac63e8515f8c075e07b
https://doi.org/10.1158/0008-5472.22409400
https://doi.org/10.1158/0008-5472.22409400
Autor:
Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia
This file contains additional Materials and Methods that are not listed in the main text.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2988722ee4d40df09a3ec26bb20ad909
https://doi.org/10.1158/0008-5472.22409403.v1
https://doi.org/10.1158/0008-5472.22409403.v1
Autor:
Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia
This file shows the Supplementary figures. Figure S1 shows the chemical structure of EGF816 and its binding to EGFR T790M mutant. Figure S2 shows the tolerability of EGF816 in the in vivo xenograft models. Figure S3 shows the in vivo PK and PD after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ab8464515db1aff3c0ba30b59f5d9
https://doi.org/10.1158/0008-5472.22409406.v1
https://doi.org/10.1158/0008-5472.22409406.v1
Autor:
Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia
This file contains the supplementary figure legends. Figure S1 shows the chemical structure of EGF816 and its binding to EGFR T790M mutant. Figure S2 shows the tolerability of EGF816 in the in vivo xenograft models. Figure S3 shows the in vivo PK and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0957d0570515c3968b8a4f91079738be
https://doi.org/10.1158/0008-5472.22409409.v1
https://doi.org/10.1158/0008-5472.22409409.v1
Autor:
Bo Liu, Sukwon Ha, H. Michael Petrassi, Kate Jacobsen, George Harb, W. Perry Gordon, Bryan Laffitte, Thanh Lam, Qihui Jin, Yong Jia, Janine E. Baaten, Minhua Qiu, Robert Hill, Shelly Meeusen, Shanshan Yan, Badry Bursulaya, Valentina Molteni, Anwesh Kamireddy, Lisa Deaton, Jianfeng Pan, You-Qing Zhang, Loren Jon, Michael DiDonato, Yahu A. Liu, Shifeng Pan, Andrew M. Schumacher, Tingting Mo, Yefen Zou, Xiaoyue Zhang, Weijun Shen, Karyn Colman, Richard Glynne, Xueshi Hao, Peter McNamara, Vân Nguyen-Tran, Zhicheng Wang, Sheryll Espinola, Bao Nguyen, Tom Y.-H. Wu, Jing Li, Qiang Ding
Publikováno v:
Journal of Medicinal Chemistry. 63:2958-2973
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach toward diabetes intervention. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e5ae5085b8fd7b08c90167919a793
https://doi.org/10.1021/acs.jmedchem.9b01624
https://doi.org/10.1021/acs.jmedchem.9b01624
Autor:
Badry Bursulaya, Yun O. Long, Jaganmohan Anumolu, Matthew McNeill, Sangamesh Badiger, Rina Fong, Michael DiDonato, Mari Manuia, Jie Li, Bender Steven Lee, Jose Juarez, Wenshuo Lu, Gerald Lelais, Daniel E. Mason, Thomas H. Marsilje, John Isbell, Kevin Johnson, Shailaja Kasibhatla, Bei Chen, Glen Spraggon, Pierre-Yves Michellys, Todd Groessl, Robert Epple, Yong Jia, Perry Gordon, Chun Li
Publikováno v:
Journal of Medicinal Chemistry. 59:6671-6689
Over the past decade, first and second generation EGFR inhibitors have significantly improved outcomes for lung cancer patients with activating mutations in EGFR. However, both resistance through a secondary T790M mutation at the gatekeeper residue a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a973c726b34b81320ef338d4a330d6
https://doi.org/10.1021/acs.jmedchem.5b01985
https://doi.org/10.1021/acs.jmedchem.5b01985
Autor:
Gérald, Lelais, Robert, Epple, Thomas H, Marsilje, Yun O, Long, Matthew, McNeill, Bei, Chen, Wenshuo, Lu, Jaganmohan, Anumolu, Sangamesh, Badiger, Badry, Bursulaya, Michael, DiDonato, Rina, Fong, Jose, Juarez, Jie, Li, Mari, Manuia, Daniel E, Mason, Perry, Gordon, Todd, Groessl, Kevin, Johnson, Yong, Jia, Shailaja, Kasibhatla, Chun, Li, John, Isbell, Glen, Spraggon, Steven, Bender, Pierre-Yves, Michellys
Publikováno v:
Journal of medicinal chemistry. 59(14)
Over the past decade, first and second generation EGFR inhibitors have significantly improved outcomes for lung cancer patients with activating mutations in EGFR. However, both resistance through a secondary T790M mutation at the gatekeeper residue a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6581993755c96201e35fb6c7ecb996e
https://pubmed.ncbi.nlm.nih.gov/27433829
https://pubmed.ncbi.nlm.nih.gov/27433829
Autor:
John A. Tainer, Chiharu Hitomi, David P. Barondeau, Michael DiDonato, J. Andrew Berglund, Greg L. Hura, S. Craig Cary, Elizabeth D. Getzoff, David S. Shin
Publikováno v:
Journal of Molecular Biology. 385:1534-1555
Prokaryotic thermophiles supply stable human protein homologs for structural biology; yet, eukaryotic thermophiles would provide more similar macromolecules plus those missing in microbes. Alvinella pompejana is a deep-sea hydrothermal-vent worm that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ce5e9ff50dc7184a03e9ac491a09d2
https://doi.org/10.1016/j.jmb.2008.11.031
https://doi.org/10.1016/j.jmb.2008.11.031