Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Michael Devereux"'
Autor:
André L.S. Santos, Ana Karina C. Lima, Simone S.C. Oliveira, Rosiane F. dos Santos, Michael Devereux, Malachy McCann, Marta H. Branquinha, Patrícia M.L. Dutra
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100093- (2022)
Leishmaniasis is a neglected tropical disease, whose chemotherapy still presents a series of severe side effects for the patient. Recently, our group published the leishmanicidal action of 1,10-phenanthroline (1), 1,10-phenanthroline-5,6-dione (phend
Externí odkaz:
https://doaj.org/article/b6a02d6e61fe4f759da82f56c525308d
Autor:
Simone S. C. Oliveira, Claudyane A. Correia, Vanessa S. Santos, Elaine F. F. da Cunha, Alexandre A. de Castro, Teodorico C. Ramalho, Michael Devereux, Malachy McCann, Marta H. Branquinha, André L. S. Santos
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 8, Iss 7, p 348 (2023)
Leishmaniasis, caused by protozoa of the genus Leishmania, encompasses a group of neglected diseases with diverse clinical and epidemiological manifestations that can be fatal if not adequately and promptly managed/treated. The current chemotherapy o
Externí odkaz:
https://doaj.org/article/6d78d366ea264f1cacf83dd39bd6d1e8
Autor:
Graziela Vargas Rigo, Fernanda Gomes Cardoso, Matheus Mendonça Pereira, Michael Devereux, Malachy McCann, André L. S. Santos, Tiana Tasca
Publikováno v:
Pathogens, Vol 12, Iss 5, p 745 (2023)
Trichomonas vaginalis is responsible for 156 million new cases per year worldwide. When present asymptomatically, the parasite can lead to serious complications, such as development of cervical and prostate cancer. As infection increases the acquisit
Externí odkaz:
https://doaj.org/article/471b5edb6059449eb946dfcaf077010c
Autor:
Louise Gallagher, Alanna Smith, Kevin Kavanagh, Michael Devereux, John Colleran, Carmel Breslin, Karl G. Richards, Malachy McCann, A. Denise Rooney
Publikováno v:
Chemistry, Vol 3, Iss 2, Pp 672-686 (2021)
Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trim
Externí odkaz:
https://doaj.org/article/6630191c104b4356acf73828988fc6e6
Autor:
Ingrid S. Sousa, Tatiana D. P. Vieira, Rubem F. S. Menna-Barreto, Allan J. Guimarães, Pauraic McCarron, Malachy McCann, Michael Devereux, André L. S. Santos, Lucimar F. Kneipp
Publikováno v:
Journal of Fungi, Vol 9, Iss 3, p 356 (2023)
The genus Fonsecaea is one of the etiological agents of chromoblastomycosis (CBM), a chronic subcutaneous disease that is difficult to treat. This work aimed to evaluate the effects of copper(II), manganese(II) and silver(I) complexes coordinated wit
Externí odkaz:
https://doaj.org/article/766d06ed383448c9ba775667334f1d30
Publikováno v:
Experimental Results, Vol 3 (2022)
The unfolded protein response has recently been implicated as a mechanism by which 1,10-phenanthroline-containing coordination compounds trigger cell death. We explored the interaction of two such compounds—one containing copper and one containing
Externí odkaz:
https://doaj.org/article/77475985196b4fbfb1cf047c30068a1d
Autor:
Simone S. C. Oliveira, Vanessa S. Santos, Michael Devereux, Malachy McCann, André L. S. Santos, Marta H. Branquinha
Publikováno v:
Pathogens, Vol 12, Iss 1, p 70 (2023)
Leishmaniasis is a neglected disease caused by protozoa belonging to the Leishmania genus. Notably, the search for new, promising and potent anti-Leishmania compounds remains a major goal due to the inefficacy of the available drugs used nowadays. In
Externí odkaz:
https://doaj.org/article/cc77a5854ed94492a6992c727955172b
Autor:
Andrés Cruz-Herranz, Frederike C. Oertel, Kicheol Kim, Ester Cantó, Garrett Timmons, Jung H. Sin, Michael Devereux, Nicholas Baker, Brady Michel, Ryan D. Schubert, Lakshmisahithi Rani, Christian Cordano, Sergio E. Baranzini, Ari J. Green
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Neurodegeneration mediates neurological disability in inflammatory demyelinating diseases of the CNS. The role of innate immune cells in mediating this damage has remained controversial with evidence for destructive and protective effects. This has c
Externí odkaz:
https://doaj.org/article/01c7e3c7a8404c0582e553222861c0db
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 8, Pp 1224-1227 (2019)
Phenanthroline ligands are important metal-binding molecules which have been extensively researched for applications in both material science and medicinal chemistry. Azobenzene and its derivatives have received significant attention because of their
Externí odkaz:
https://doaj.org/article/ea245189067047db8b4ba3cd382bf3db
Autor:
Marcela Q. Granato, Thaís P. Mello, Renata S. Nascimento, Marcos D. Pereira, Thabatta L. S. A. Rosa, Maria C. V. Pessolani, Malachy McCann, Michael Devereux, Marta H. Branquinha, André L. S. Santos, Lucimar F. Kneipp
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Phialophora verrucosa is a dematiaceous fungus that causes mainly chromoblastomycosis, but also disseminated infections such as phaeohyphomycosis and mycetoma. These diseases are extremely hard to treat and often refractory to current antifungal ther
Externí odkaz:
https://doaj.org/article/19fd025d7f694853b9202e6cff90c930