Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael Del Tatto"'
Autor:
James R Klinger, Mandy Pereira, Michael Del Tatto, Mark S Dooner, Sicheng Wen, Peter J Quesenberry, Olin D Liang
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-11 (2021)
Rationale Mesenchymal stem cell extracellular vesicles (MSC EVs) reverse pulmonary hypertension, but little information is available regarding what dose is effective and how often it needs to be given. This study examined the effects of dose reductio
Externí odkaz:
https://doaj.org/article/d2a2108c35414c929c1c0761e3928f19
Autor:
Sicheng Wen, Mark Dooner, Elaine Papa, Michael Del Tatto, Mandy Pereira, Theodor Borgovan, Yan Cheng, Laura Goldberg, Olin Liang, Giovanni Camussi, Peter Quesenberry
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5468 (2019)
We have previously shown that injury induced by irradiation to murine marrow can be partially or completely reversed by exposure to human or murine mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs). Investigation of the biodistribution
Externí odkaz:
https://doaj.org/article/25eb97977e2d4845adf2ef3a45fa37e9
Autor:
Mark S Dooner, Connor Stewart, Yanhui Deng, Elaine Papa, Mandy Pereira, Michael Del Tatto, Shannon Johnson, Sicheng Wen, Ashley Amaral, Jason Aliotta, Peter J Quesenberry, Laura R Goldberg
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207444 (2018)
Extracellular vesicles (EVs) are important mediators of intercellular communication and have been implicated in myriad physiologic and pathologic processes within the hematopoietic system. Numerous factors influence the ability of EVs to communicate
Externí odkaz:
https://doaj.org/article/211c960afec6493d91d1a49bc9804fcb
Autor:
Laura R. Goldberg, Mark S. Dooner, Elaine Papa, Mandy Pereira, Michael Del Tatto, Yan Cheng, Sicheng Wen, Peter J. Quesenberry
Publikováno v:
Stem cell reviews and reports. 18(7)
Hematopoietic stem cells express differentiation markers B220 and Gr1 and are proliferative. We have shown that the expression of these entities changes with cell cycle passage. Overall, we conclude that primitive hematopoietic stem cells alter their
Autor:
James R. Klinger, Corey E. Ventetuolo, Alexander S. Brodsky, Jason M. Aliotta, Mandy Pereira, Mark S. Dooner, Sicheng Wen, Keith Q. Wu, Laura R. Goldberg, Michael Del Tatto, Peter J. Quesenberry, Theodore Borgovan, Olin D Liang
Publikováno v:
Am J Respir Cell Mol Biol
Mesenchymal stem cell extracellular vesicles attenuate pulmonary hypertension, but their ability to reverse established disease in larger animal models and the duration and mechanism(s) of their effect are unknown. We sought to determine the efficacy
Autor:
Euy-Myoung Jeong, Mandy Pereira, Eui-Young So, Keith Q Wu, Michael Del Tatto, Sicheng Wen, Mark S Dooner, Patrycja M Dubielecka, Anthony M Reginato, Corey E Ventetuolo, Peter J Quesenberry, James R Klinger, Olin D Liang
Publikováno v:
Cardiovascular research. 118(16)
Aims Pulmonary arterial hypertension (PAH) is a fatal disease without a cure. Previously, we found that transcription factor RUNX1-dependent haematopoietic transformation of endothelial progenitor cells may contribute to the pathogenesis of PAH. Howe
Autor:
James R. Klinger, Laura R. Goldberg, Corey E. Ventetuolo, Jason M. Aliotta, Sicheng Wen, Elaine Papa, Mark S. Dooner, Peter J. Quesenberry, Mandy Pereira, Michael Del Tatto, Yan Cheng, Olin D Liang
Publikováno v:
Stem Cells Translational Medicine
The role of bone marrow (BM) cells in modulating pulmonary hypertensive responses is not well understood. Determine if BM-derived endothelial progenitor cells (EPCs) induce pulmonary hypertension (PH) and if this is attenuated by mesenchymal stem cel
Autor:
Jill A. Kreiling, Laura R Goldberg, Michael Del Tatto, Peter J. Quesenberry, Yan Cheng, Sicheng Wen, Mandy Pereira, Elaine Papa, Mark S. Dooner
Publikováno v:
Blood. 136:37-37
Extracellular vesicles (EVs) are critical mediators of intercellular communication within the bone marrow niche and have been implicated in numerous features of aging. However, their role in natural hematopoietic stem cell (HSC) aging has not been fu
Autor:
Peter J. Quesenberry, Mark S. Dooner, Mandy Pereira, Jason M. Aliotta, Corey E. Ventetuolo, Laura R. Goldberg, Sicheng Wen, Elaine Papa, Grayson L. Baird, James R. Klinger, Michael Del Tatto
Publikováno v:
Cardiovascular Research. 110:319-330
Aims Extracellular vesicles (EVs) from mice with monocrotaline (MCT)-induced pulmonary hypertension (PH) induce PH in healthy mice, and the exosomes (EXO) fraction of EVs from mesenchymal stem cells (MSCs) can blunt the development of hypoxic PH. We
Autor:
Mark S. Dooner, Laura R Goldberg, Mandy Pereira, Elaine Papa, Sicheng Wen, Peter J. Quesenberry, Yan Cheng, Michael Del Tatto
Publikováno v:
Blood. 134:3723-3723
Aging is accompanied by loss of tissue homeostasis, deterioration in organ function and an increased incidence of disease. Age-related changes in the adult stem/progenitor compartment likely drive much of this aging phenotype. For the hematopoietic s