Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael DeRan"'
Autor:
Lizhi He, Jhih-Hua Jhong, Qi Chen, Kai-Yao Huang, Karin Strittmatter, Johannes Kreuzer, Michael DeRan, Xu Wu, Tzong-Yi Lee, Nikolai Slavov, Wilhelm Haas, Alexander G. Marneros
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109955- (2021)
Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a compreh
Externí odkaz:
https://doaj.org/article/f157ca1578fa466bb58ec28d74dce0d4
Autor:
Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh, Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, Xu Wu
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 495-503 (2014)
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcr
Externí odkaz:
https://doaj.org/article/04aad9faacbb4c398538fe8973f616b7
Autor:
Amy D. Westerling-Bui, Eva Maria Fast, Thomas W. Soare, Srinivasan Venkatachalan, Michael DeRan, Alyssa B. Fanelli, Sergii Kyrychenko, Hien Hoang, Grinal M. Corriea, Wei Zhang, Maolin Yu, Matthew Daniels, Goran Malojcic, Xin-Ru Pan-Zhou, Mark W. Ledeboer, Jean-Christophe Harmange, Maheswarareddy Emani, Thomas T. Tibbitts, John F. Reilly, Peter Mundel
Publikováno v:
Science Advances. 8
Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery. Current approaches for PD studies, including the analysis of novel kidney disease targeting therapeutic agents, are limited to animal models with unclear translata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40449dd6e041ef112e7753de2cea4d8c
https://doi.org/10.1126/sciadv.abj5633
https://doi.org/10.1126/sciadv.abj5633
Autor:
Wei Zhang, Michael DeRan, Goran Malojčić, Xin-Ru Pan-Zhou, Maheswarareddy Emani, Jean-Christophe Harmange, Alyssa B. Fanelli, Hien Hoang, Peter Mundel, John F. Reilly, Mark W. Ledeboer, Amy Westerling-Bui, Maolin Yu, Srinivasan Venkatachalan, Sergii Kyrychenko, Thomas T. Tibbitts, Eva Maria Fast, Thomas W. Soare, Grinal M. Corriea
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims A major challenge in drug discovery is gaining confidence in the human relevance of pre-clinical animal studies. While human iPSC-derived organoids offer exciting opportunities to address this, concerns about applicability and sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b0f85b8aa6784f9df0c3d73f0c2b00
https://doi.org/10.1093/ndt/gfaa139.so038
https://doi.org/10.1093/ndt/gfaa139.so038
Autor:
Sophia Z, Shalhout, Peng-Yu, Yang, Edyta M, Grzelak, Kayla, Nutsch, Sida, Shao, Claudio, Zambaldo, Jonathan, Iaconelli, Lara, Ibrahim, Caroline, Stanton, Stormi R, Chadwick, Emily, Chen, Michael, DeRan, Sijia, Li, Mitchell, Hull, Xu, Wu, Arnab K, Chatterjee, Weijun, Shen, Fernando D, Camargo, Peter G, Schultz, Michael J, Bollong
Publikováno v:
Nature chemical biology. 17(7)
The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a proproliferative transcriptional program that controls the fate of somatic stem cells and the regenerative responses of certain tissues. As such, agents that activate YAP m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::113abd6d43aecc5052478625d0c29143
https://pubmed.ncbi.nlm.nih.gov/33758335
https://pubmed.ncbi.nlm.nih.gov/33758335
Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal
Autor:
Jong-Ryoul Choi, Michael DeRan, Baoen Chen, Jixiao Niu, Gopala K. Jarugumilli, Yang Sun, PuiYee Chan, Meilan Yu, Xu Wu, Cheng Lin, Baohui Zheng, Raphael A. Zoeller
Publikováno v:
ACS Chemical Biology. 13:1130-1136
Lipid-derived electrophiles (LDEs) are reactive metabolites, which can covalently modify proteins and DNA and regulate diverse cellular processes. 2- trans-Hexadecenal (2-HD) is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorgan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102f8579bc74f239dcc0d2deb0585f4
https://doi.org/10.1021/acschembio.7b01063
https://doi.org/10.1021/acschembio.7b01063
Autor:
Qi Chen, Michael DeRan, Kai-Yao Huang, Johannes Kreuzer, Xu Wu, Jhih-Hua Jhong, Karin Strittmatter, Lizhi He, Tzong-Yi Lee, Alexander G. Marneros, Wilhelm Haas, Nikolai Slavov
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109955-(2021)
Cell reports
Cell reports
SUMMARY Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a comprehe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f960b011321494870e2e8f756a56e49
https://doi.org/10.1016/j.celrep.2021.109955
https://doi.org/10.1016/j.celrep.2021.109955
Autor:
Jennifer L. Cotton, Gopala K. Jarugumilli, Michael DeRan, Rui Li, Jordi Xiol, Xu Wu, Xuelian Luo, Randy L. Johnson, Y. Tony Ip, Lihua Julie Zhu, Junhao Mao, Qi Li, Yang Sun, Joyce Li, Andrew B. Leiter, Kyvan Dang, PuiYee Chan, Shun Liu, Lifang Ma, Fernando D. Camargo
Publikováno v:
Cell stem cell. 26(5)
Summary Intestinal homeostasis is tightly regulated by complex yet poorly understood signaling networks. Here, we demonstrate that Lats1/2, the core Hippo kinases, are essential to maintain Wnt pathway activity and intestinal stem cells. Lats1/2 dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1471e5f2d2ea7b677b93eaa99fb484
https://pubmed.ncbi.nlm.nih.gov/32386550
https://pubmed.ncbi.nlm.nih.gov/32386550
Autor:
Xiao Han, Hua Deng, Duojia Pan, Baohui Zheng, Gopala K. Jarugumilli, Michael DeRan, Jianzhong Yu, Xu Wu, Xuelian Luo, PuiYee Chan
Publikováno v:
Nature chemical biology
TEA domain (TEAD) transcription factors bind to the coactivators YAP and TAZ and regulate the transcriptional output of the Hippo pathway, playing critical roles in organ size control and tumorigenesis. Protein S-palmitoylation attaches a fatty acid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844fd98ad57151610691db7de55b6d39
http://europepmc.org/articles/PMC4798901
http://europepmc.org/articles/PMC4798901
Autor:
Christian Lange, Johan Hofkens, Sandra Liekens, Hongling Huang, Xu Wu, Joris Souffreau, Giorgio Saladino, Guy Eelen, Jaap D. van Buul, Saar Vandekeere, Wouter H. Lamers, Xuri Li, Gopala K. Jarugumilli, Federico Comitani, Annalisa Zecchin, Jermaine Goveia, Bert Cruys, Katleen Brepoels, Joanna Kalucka, Bart Ghesquière, Leanne M. Ramer, Ulrike Bruning, Michael DeRan, Charlotte Dubois, Francesco Luigi Gervasio, Jos van Rijssel, Stefan Vinckier, Sabine Wyns, Yi I. Wu, Mieke Dewerchin, Francisco Morales-Rodriguez, Susana Rocha, Rongyuan Chen, Richard M Cubbon, Luc Schoonjans, Lucas Treps, Peter Carmeliet, Anna Rita Cantelmo, Jurgen Haustraete
Publikováno v:
Nature, 561(7721), 63-69. Nature Publishing Group
Nature
Nature
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activity in these cells at physiological glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d200895d1b6e0032d3de22a7951093
