Epigenetic and genomic profiling of chordoid meningioma: implications for clinical management

Autor: Elena V. Daoud, Kelsey Zhu, Bruce Mickey, Hussein Mohamed, Mandisa Wen, Michael Delorenzo, Ivy Tran, Jonathan Serrano, Kimmo J. Hatanpaa, Jack M. Raisanen, Matija Snuderl, Chunyu Cai

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-12 (2022)

Abstract Chordoid meningioma is a morphological variant of meningioma designated as WHO grade 2. However, the recurrence rates varied widely in different case series, and to date, a unifying molecular genetic signature has not been identified. Among

Externí odkaz: https://doaj.org/article/13cb9aba473648c1bc9705a74565ba16

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

Autor: Xin Cui, Chao Ma, Varshini Vasudevaraja, Jonathan Serrano, Jie Tong, Yansong Peng, Michael Delorenzo, Guomiao Shen, Joshua Frenster, Renee-Tyler Tan Morales, Weiyi Qian, Aristotelis Tsirigos, Andrew S Chi, Rajan Jain, Sylvia C Kurz, Erik P Sulman, Dimitris G Placantonakis, Matija Snuderl, Weiqiang Chen

Publikováno v: eLife, Vol 9 (2020)

Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. Here, we report a microfluidics-based, patie

Externí odkaz: https://doaj.org/article/17d5105f91be4e3ab42eceb0226f07ee

Supplementary Data from DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome

Autor: Kwok-Kin Wong, Matija Snuderl, Harvey Pass, Thales Papagiannakopoulos, Aristotelis Tsirigos, Andre L. Moreira, Christina Almonte, Soumyadip Sahu, Jiehui Deng, Hua Zhang, Michael DeLorenzo, Brett W. Guidry, Jonathan Serrano, Hussein Mohamed, Kristen Labbe, Varshini Vasudevaraja, Kayla Guidry

Supplementary Data from DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd16f31badeb28a2a3da1e2dde84e04
https://doi.org/10.1158/1078-0432.22487151

Supplementary Figure from DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome

Autor: Kwok-Kin Wong, Matija Snuderl, Harvey Pass, Thales Papagiannakopoulos, Aristotelis Tsirigos, Andre L. Moreira, Christina Almonte, Soumyadip Sahu, Jiehui Deng, Hua Zhang, Michael DeLorenzo, Brett W. Guidry, Jonathan Serrano, Hussein Mohamed, Kristen Labbe, Varshini Vasudevaraja, Kayla Guidry

Supplementary Figure from DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a49669f205bba2f1b67f39a290855d
https://doi.org/10.1158/1078-0432.22487130.v1

PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

Autor: Elli Papaemmanuil, Bastiaan B. J. Tops, Torben Stamm Mikkelsen, Fanny Vandenbos, Christof M. Kramm, Nancy Bouvier, Katharina Filipski, Nagma Dalvi, Kristian W. Pajtler, Andrea Wittmann, Christine Haberler, Till Milde, Olaf Witt, Hildegard Dohmen, Martin Sill, George Jour, Matija Snuderl, Allison M. Martin, Torsten Pietsch, Antonis Kattamis, Nicholas G. Gottardo, Emmanuelle Uro-Coste, Philipp Sievers, Andreas von Deimling, Frank Alvaro, Simone Schmid, Damian Stichel, Jonas Ecker, Marcel Kool, Johannes Gojo, Lidija Kitanovski, Michal Zapotocky, Michael Delorenzo, Catherine Godfraind, Florian Selt, Alexander C Sommerkamp, Adam S. Levy, Pieter Wesseling, Evelina Miele, Lenka Krskova, Pengbo Beck, Matthias A. Karajannis, David Scheie, Jordan R. Hansford, Natalie Jäger, Karam T. Alhalabi, Andrey Korshunov, Felix Sahm, Mariëtte E.G. Kranendonk, David T.W. Jones, David Sumerauer, Chris Jones, Katja von Hoff, Heike Peterziel, Stefan M. Pfister, Dominik Sturm, Martin G. McCabe, Ina Oehme, Maria Filippidou, Claude Alain Maurage, Ingrid Øra, Till Acker

Publikováno v: Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Acta Neuropathologica
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C-A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M & Sahm, F 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C-A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, pp. 841–857 . https://doi.org/10.1007/s00401-021-02354-8
Acta Neuropathologica, 142(5), 841-857. Springer Verlag

Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from his

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3b21e740f6cfda345b6f64cbf7586e
https://pure.au.dk/ws/files/274397587/Alhalabi2021_Article_PATZ1FusionsDefineANovelMolecu.pdf