Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael David Golden"'
Autor:
Michael David Golden, Mark Hoyle, Sarah-Kate Cantlie, Trevor Churchill, Hannah Ashton, Dobson Benjamin Charles, Paul A. Bethel, Cooper Katie Grace
Publikováno v:
Organic Process Research & Development. 23:1101-1104
Work to assess the thermal properties of 2-butynoic acid (a precursor to acalabrutinib) has revealed the potential for thermal runaway on heating; testing using accelerated rate calorimetry (ARC) showed exothermic onset from 135 °C, precluding short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9f2dca560fff85bccc541519707cc5
https://doi.org/10.1021/acs.oprd.9b00106
https://doi.org/10.1021/acs.oprd.9b00106
Publikováno v:
Organic Process Research & Development. 22:1458-1460
Optimization and application of the reported synthesis of (3-chloropyrazin-2-yl)methanamine 3 have provided a high yielding, fully telescoped procedure to key intermediate 5 in the synthesis of acalabrutinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69f9ed035b95767b2bcb7cc3a1e7cb7
https://doi.org/10.1021/acs.oprd.8b00287
https://doi.org/10.1021/acs.oprd.8b00287
Autor:
Melanie Ronsheim, Shao Hong Zhou, Graham Richard Lawton, Alistair Boyd, Simon R. Linke, Yuriy B. Kalyan, Matthew Charles Evans, Rebecca Murphy, David Milne, Michael David Golden, Matthew Ball, Saibaba Racha, Gareth AstraZeneca R D Charnwood Ensor, Alex Telford
Publikováno v:
Organic Process Research & Development. 20:1799-1805
Process development work to provide an efficient, robust, and cost-effective manufacturing route to avibactam, a β-lactamase inhibitor is presented herewith. Aspects of this optimization work include the counterintuitive introduction of a protecting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::059cd3e1f954b95fb8c863a984609c71
https://doi.org/10.1021/acs.oprd.6b00268
https://doi.org/10.1021/acs.oprd.6b00268
Autor:
Christopher John Squire, Simone Tomasi, Julie Reilly, Kevin William Leslie, Denise Watt, Lianne Frodsham, David J. Klauber, Michael David Golden, Claire S. MacLeod, Martin N. Kenworthy, Andrew S. Wells, Rebecca E. Meadows, Susan Hard, Keith R. Mulholland
Publikováno v:
Organic Process Research & Development. 17:1123-1130
ω-Transaminase enzyme chemistry provides an excellent methodology to build synthetically useful chiral amines from their corresponding ketones. An application of this methodology, providing a long-term commercial manufacturing route to a JAK2 kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebc65a2e80bdcc5e235569e3cc72e9bc
https://doi.org/10.1021/op400133d
https://doi.org/10.1021/op400133d
Autor:
Harrie Straatman, Christopher John Squire, Michael David Golden, Daniel Mink, Andrew S. Wells, Rebecca E. Meadows, Elise Meulenbroeks, Martin Schürmann, Oliver May, Keith R. Mulholland, Hans Kierkels
Publikováno v:
Organic Process Research & Development. 17:1117-1122
Screening of 60 transaminases using three different amine donors found that the ω-transaminase from Vibrio fluvialis together with (S)-α-methylbenzylamine to be the most promising combination to deliver the desired (S)-1-(5-fluoropyrimidin-2-yl)-et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00c36999ee6d956fdeaa05c32807b55e
https://doi.org/10.1021/op400131h
https://doi.org/10.1021/op400131h
Autor:
Daniel Mink, Christopher John Squire, Andrew S. Wells, Rebecca E. Meadows, Michael David Golden, Hans Kierkels, Oliver May, Keith R. Mulholland, Harrie Straatman, Elise Meulenbroeks, Martin Schürmann
Publikováno v:
Practical Methods for Biocatalysis and Biotransformations 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7746755d41c98226d9b75c7c6331d69a
https://doi.org/10.1002/9781118697856.ch09
https://doi.org/10.1002/9781118697856.ch09
Autor:
Mark Drew, J. Gair Ford, Alistair Boyd, Kevin William Leslie, Ji-long Jiang, Bob Suchozak, Stephen Gottschling, Gwydion Churchill, Sarah Lyons, Paula Tomlin, Josephine Lo, Murray Watson AstraZeneca Cuthbert, Matthew Ball, Michael David Golden, Andrew Stark, Lianne Frodsham, Ben McKeever-Abbas, Mark Richard Fielding, Abraham Hajar
Publikováno v:
Organic Process Research & Development. 16:741-747
The intramolecular Diels–Alder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, p...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c528a5c1ed16c94382062fccf77b5bac
https://doi.org/10.1021/op300002f
https://doi.org/10.1021/op300002f
Publikováno v:
Tetrahedron Letters. 48:4627-4630
A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of ( S )-(−)- N -acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cfe39d45568bf2dd2bc86a873a0f43c
https://doi.org/10.1016/j.tetlet.2007.04.103
https://doi.org/10.1016/j.tetlet.2007.04.103