Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice

Autor: Ian N. Hines, Michael Kremer, Sherri M. Moore, Michael D. Wheeler

Publikováno v: Biological Research, Vol 51, Iss 1, Pp 1-16 (2018)

Abstract Background Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whether PPARα plays a ro

Externí odkaz: https://doaj.org/article/09a8a013d10b4801985039b9fbd376c6

Fatty acid profile driven by maternal diet is associated with the composition of human milk microbiota

Autor: Alan J. Marsh, M. Andrea Azcarate-Peril, Mashael R. Aljumaah, Jessica Neville, Maryanne T. Perrin, Lisa L. Dean, Michael D. Wheeler, Ian N. Hines, Roman Pawlak

Little is known regarding the impact of diet on the breast milk microbiome. We hypothesized that vegan, vegetarian, and omnivore diets would impact the human milk microbiota. We also aimed to explore associations between human milk fatty acid concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b71c76e998101ff6c11d9cd8f4dbf8d

Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice

Autor: Michael D. Wheeler, Ian N. Hines, Michael Kremer, Sherri M. Moore

Publikováno v: Biological Research, Volume: 51, Article number: 5, Published: 08 MAR 2018
Biological Research
Biological Research, Vol 51, Iss 1, Pp 1-16 (2018)

Background Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whether PPARα plays a role in T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051d358e7d56b651961d2460c7291995
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100204&lng=en&tlng=en

Smad3 signaling in the regenerating liver: implications for the regulation of IL-6 expression

Autor: Giulia Manzini, Michael Kremer, Ian N. Hines, Gakuhei Son, Sherri M. Moore, Michael D. Wheeler, Amber Norris, Kun Zhang

Publikováno v: Transplant International. 27:748-758

Liver regeneration is vital for graft survival and adequate organ function. Smad activation regulates hepatocyte proliferation and macrophage function. The aim of the current study was to evaluate the impact of Smad3 signaling during liver regenerati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a4a25932ba3726c2218766a9580c4f
https://doi.org/10.1111/tri.12322

Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

Autor: Ashley W. Perry, Emmanuel Thomas, Nico van Rooijen, Richard A. Rippe, Ian N. Hines, Richard J. Milton, Michael W. Fried, Michael Kremer, Michael D. Wheeler, Steven Zacks

Publikováno v: Hepatology, 51(1), 130-141. John Wiley and Sons Ltd
Kremer, M, Thomas, E, Milton, R J, Perry, A W, van Rooijen, N, Wheeler, M D, Zacks, S, Fried, M, Rippe, R A & Hines, I N 2010, ' Kupffer Cell and Interleukin-12-Dependent Loss of Natural Killer T Cells in Hepatosteatosis ', Hepatology, vol. 51, no. 1, pp. 130-141 . https://doi.org/10.1002/hep.23292

Hepatosteatosis is associated with increased expression of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-12, major T helper (Th) 1 cytokines, and reduced hepatic natural killer T (NKT) cell numbers. The relationship between lipid accumula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868a5cec0d9526873c676e5c0afb488c
https://doi.org/10.1002/hep.23292